Authors: Jacques S, van der Sloot AM, Huard CC, Coulombe-Huntington J, Tsao S, Tollis S, Bertomeu T, Culp EJ, Pallant D, Cook MA, Bonneil E, Thibault P, Wright GD and Tyers M.
Reference: Genetics
DOI: 10.1534/genetics.119.302851
PMID: 32094149
Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling →
Authors: Culp EJ, Waglecher N, Wang W, Fiebig-Comyn AA, Hsu Y, Koteva K, Sychantha D, Coombes BK, Van Nieuwenhze MS, Brun YV and Wright GD
Reference: Nature
DOI: 10.1038/s41586-020-1990-9
PMID: 32051588
Suppression of β-Lactam Resistance by Aspergillomarasmine A Is Influenced by both the Metallo-β-Lactamase Target and the Antibiotic Partner →
Authors: Rotondo CM, Sychantha D, Koteva K and Wright GD
Reference: Antimicrob Agents Chemother.
DOI: 10.1128/AAC.01386-19
PMID: 31932375
CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database →
Authors: Alcock BP, Raphenya AR, Lau TTY, Tsang KK, Bouchard M, Edalatmand A, Huynh W, Nguyen AV, Cheng AA, Liu S, Min SY, Miroshnichenko A, Tran HK, Werfalli RE, Nasir JA, Oloni M, Speicher DJ, Florescu A, Singh B, Faltyn M, Hernandez-Koutoucheva A, Sharma AN, Bordeleau E, Pawlowski AC, Zubyk HL, Dooley D, Griffiths E, Maguire F, Winsor GL, Beiko RG, Brinkman FSL, Hsiao WWL, Domselaar GV, McArthur AG.
Reference: Nucleic Acids Res.
DOI: 10.1093/nar/gkz935
PMID: 31665441
Capturing the Resistome: a Targeted Capture Method To Reveal Antibiotic Resistance Determinants in Metagenomes →
Authors: Guitor AK, Raphenya AR, Klunk J, Kuch M, Alcock B, Surette MG, McArthur AG, Poinar HN and Wright GD
Reference: Antimicrob Agents Chemother.
DOI: 10.1128/AAC.01324-19
PMID: 31611361
Antibiotic Dereplication Using the Antibiotic Resistance Platform →
Authors: Zubyk HL, Cox G and Wright GD
Reference: J Vis Exp.
DOI: 10.3791/60536
PMID: 31680676
The ADEP Biosynthetic Gene Cluster in Streptomyces hawaiiensis NRRL 15010 Reveals an Accessory clpP Gene as a Novel Antibiotic Resistance Factor →
Authors: Thomy D, Culp E, Adamek M, Cheng EY, Ziemert N, Wright GD, Sass P and Brötz-Oesterhelt H.
Reference: Appl Environ Microbiol.
DOI: 10.1128/AEM.01292-19
PMID: 31399403
Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics →
Authors: Culp EJ, Yim G, Waglechner N, Wang W, Pawlowski AC and Wright GD
Reference: Nat Biotechnol.
DOI: 10.1038/s41587-019-0241-9
PMID: 31501558
Phylogenetic reconciliation reveals the natural history of glycopeptide antibiotic biosynthesis and resistance →
Authors: Waglechner N, McArthur AG, and Wright GD
Reference: Nat Microbiol.
DOI: 10.1038/s41564-019-0531-5
PMID: 31406334
Environmental and clinical antibiotic resistomes, same only different →
Authors: Wright GD
Reference: Curr Opin Microbiol.
DOI: 10.1016/j.mib.2019.06.005
PMID: 31330416
Drug combinations: a strategy to extend the life of antibiotics in the 21st century →
Authors: Tyers M and Wright GD
Reference: Nat Reviews Microbiol.
DOI: 10.1038/s41579-018-0141-x
PMID: 30683887
Unlocking the Potential of Natural Products in Drug Discovery →
Authors: Wright GD
Reference: Microb. Biotechnol.
DOI: 10.1111/1751-7915.13351
PMID: 30565871
Heterologous expression-facilitated natural products’ discovery in actinomycetes →
Authors: Xu M, Wright GD
Reference: J Ind Microbiol Biotechnol.
DOI: 10.1007/s10295-018-2097-2
PMID: 30446891
Antimicrobial Resistance and Respiratory Infections →
Authors: Guitor AK, Wright GD
Reference: Chest
DOI: 10.1016/j.chest.2018.06.019
PMID: 29959904
Tri-chlorination of a teicoplanin type glycopeptide antibiotic by the halogenase StaI evades resistance →
Authors: Yim G, Wang W, Pawlowski AC, Wright GD
Reference: Antimicrob Agents Chemother
DOI: 10.1128/AAC.01540-18
PMID: 30275088
Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes →
Authors: Cox G, Ejim L, Stogios PJ, Koteva K, Bordeleau E, Sieron AO, Savchenko A, Serio AW, Krause KM, Wright GD
Reference: ACS Infectious Diseases 2018
DOI: 10.1021/acsinfecdis.8b00001
PMID: 29634241
Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis →
Authors: Stogios PJ, Cox G, Zubyk HL, Evdokimova E, Wawrzak Z, Wright GD, Savchenko A
Reference: ACS Chemical Biology 2018 13 (5), 1322-1332
DOI: 10.1021/acschembio.8b00116
PMID: 29631403
Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action. →
Authors: Koteva K, Cox G, Kelso JK, Surette MD, Zubyk HL, Ejim L, Stogios P, Savchenko A, Sørensen, Wright GD
Reference: Cell Chemical Biology 2018 Jan 26. pii: S2451-9456(18)30031-X
DOI: 10.1016/j.chembiol.2018.01.009.
PMID: 29398560
The evolution of substrate discrimination in macrolide antibiotic resistance enzymes. →
Authors: Pawlowski AC, Stogios PJ, Koteva K, Skarina T, Evdokimova E, Savchenko A, Wright GD
Reference: Nature Communications 2018 ;9(1):112
DOI: 10.1038/s41467-017-02680-0.
PMID: 29317655
The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies. →
Authors: Pawlowski AC, Westman EL, Koteva K, Waglechner N, Wright GD
Reference: ISME vol 12, 885–897
DOI: 10.1038/s41396-017-0017-5
PMID: 29259290