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The Wright Lab

  • Welcome
  • Lab News
  • Team
    • Gerry Wright
    • The Lab
  • Research
    • An Overview
    • Antimicrobial Discovery
    • Antibiotic Resistance
  • Publications
  • Platforms
    • Wright Actinomycete Collection
    • Wright Clinical Collection
    • Antibiotic Resistance Platform
    • The Comprehensive Antibiotic Resistance Database
  • Articles
  • Contact

Targeting bacterial nickel transport with aspergillomarasmine A suppresses virulence-associated Ni-dependent enzymes →

Authors: Sychantha D, Chen X, Koteva K, Prehna G, Wright G.D.
Reference: Nature Communications 
DOI:  10.1038/s41467-024-48232-1
PMID: 38740750

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tags: 2024, AMA, Dave Sychantha
Monday 06.10.24
Posted by Wright Lab
 

ClpP inhibitors are produced by a widespread family of bacterial gene clusters →

Authors: Culp EJ, Sychantha D, Hobson C, Pawlowski AC, Prehna G, Wright GD.
Reference: Nat Microbiol.
DOI: 10.1038/s41564-022-01073-4.
PMID: 35246663.

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tags: 2022, Feature, Beth Culp, Dave Sychantha, Christian Hobson, Andrew Pawlowski
Friday 03.04.22
Posted by Gerry Wright
 

Three-Dimensional Structure and Optimization of the Metallo-β-Lactamase Inhibitor Aspergillomarasmine A →

Authors: Koteva K, Sychantha D, Rotondo CM, Hobson C, Britten JF, Wright GD.
Reference: ACS Omega.
DOI: 10.1021/acsomega.1c05757.
PMID: 35155911.

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tags: 2022, Kalinka Koteva, Caitlyn Rotondo, Dave Sychantha, Christian Hobson, Antibiotic Adjuvants
Wednesday 01.26.22
Posted by Gerry Wright
 

Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2 →

Authors: Sychantha D, Rotondo CM, Tehrani KHME, Martin NI, Wright GD.
Reference: J Biol Chem.
DOI: 10.1016/j.jbc.2021.100918.
PMID: PMC8319579.

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tags: 2021, Caitlyn Rotondo, Dave Sychantha, Antibiotic Adjuvants
Friday 06.25.21
Posted by Gerry Wright
 

Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling →

Authors: Culp EJ, Waglecher N, Wang W, Fiebig-Comyn AA, Hsu Y, Koteva K, Sychantha D, Coombes BK, Van Nieuwenhze MS, Brun YV and Wright GD
Reference: Nature
DOI: 10.1038/s41586-020-1990-9
PMID: 32051588

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tags: 2020, Beth Culp, Nicholas Waglechner, Wenliang Wang, Kalinka Koteva, Dave Sychantha, Feature, WAC, Novel Therapeutics
Wednesday 02.12.20
Posted by Gerry Wright
 

Suppression of β-Lactam Resistance by Aspergillomarasmine A Is Influenced by both the Metallo-β-Lactamase Target and the Antibiotic Partner →

Authors: Rotondo CM, Sychantha D, Koteva K and Wright GD
Reference: Antimicrob Agents Chemother.
DOI: 10.1128/AAC.01386-19
PMID: 31932375

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tags: 2020, Caitlyn Rotondo, Dave Sychantha, Kalinka Koteva, Feature, WAC, Antibiotic Adjuvants
Tuesday 01.14.20
Posted by Gerry Wright
 

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