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The Wright Lab

  • Welcome
  • Lab News
  • Team
    • Gerry Wright
    • The Lab
  • Research
    • An Overview
    • Antimicrobial Discovery
    • Antibiotic Resistance
  • Publications
  • Platforms
    • Wright Actinomycete Collection
    • Wright Clinical Collection
    • Antibiotic Resistance Platform
    • The Comprehensive Antibiotic Resistance Database
  • Articles
  • Contact

Three-Dimensional Structure and Optimization of the Metallo-β-Lactamase Inhibitor Aspergillomarasmine A →

Authors: Koteva K, Sychantha D, Rotondo CM, Hobson C, Britten JF, Wright GD.
Reference: ACS Omega.
DOI: 10.1021/acsomega.1c05757.
PMID: 35155911.

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tags: 2022, Kalinka Koteva, Caitlyn Rotondo, Dave Sychantha, Christian Hobson, Antibiotic Adjuvants
Wednesday 01.26.22
Posted by Gerry Wright
 

Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2 →

Authors: Sychantha D, Rotondo CM, Tehrani KHME, Martin NI, Wright GD.
Reference: J Biol Chem.
DOI: 10.1016/j.jbc.2021.100918.
PMID: PMC8319579.

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tags: 2021, Caitlyn Rotondo, Dave Sychantha, Antibiotic Adjuvants
Friday 06.25.21
Posted by Gerry Wright
 

Venturicidin A, A Membrane-active Natural Product Inhibitor of ATP synthase Potentiates Aminoglycoside Antibiotics →

Authors: Yarlagadda V, Medina R and Wright GD
Reference: Sci Rep.
DOI: 10.1038/s41598-020-64756-0
PMID: 32424122

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tags: 2020, Venky Yarlagadda, Ricardo Medina, WAC, Antibiotic Adjuvants
Monday 05.18.20
Posted by Gerry Wright
 

Suppression of β-Lactam Resistance by Aspergillomarasmine A Is Influenced by both the Metallo-β-Lactamase Target and the Antibiotic Partner →

Authors: Rotondo CM, Sychantha D, Koteva K and Wright GD
Reference: Antimicrob Agents Chemother.
DOI: 10.1128/AAC.01386-19
PMID: 31932375

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tags: 2020, Caitlyn Rotondo, Dave Sychantha, Kalinka Koteva, Feature, WAC, Antibiotic Adjuvants
Tuesday 01.14.20
Posted by Gerry Wright
 

Inhibitors of metallo-β-lactamases. →

Authors: CM Rotondo and GD Wright
Reference: Current Opinion in Microbiology 2017 39: 96-105
PMID: 29154026

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tags: 2017, Caitlyn Rotondo, Antibiotic Adjuvants
Thursday 11.16.17
Posted by Wright Lab
 

A Common Platform for Antibiotic Dereplication and Adjuvant Discovery →

Authors: Cox G, Sieron A, King AM, De Pascale G, Pawlowski AC, Koteva K, Wright GD.
Reference: Cell Chem Biol. 2016 Nov 29. pii: S2451-9456(16)30434-2. doi: 10.1016/j.chembiol.2016.11.011.
PMID: 28017602

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tags: 2016, Georgina Cox, Antibiotic Adjuvants, Andrew Pawlowski, Arthur Sieron, Kalinka Koteva, ARP
Tuesday 11.29.16
Posted by Wright Lab
 

An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens →

Authors: Nicole Robbins, Michaela Spitzer, Tennison Yu, Robert P Cerone, Anna K Averette, Yong-Sun Bahn, Joseph Heitman, Donald C Sheppard, Mike Tyers, Gerard D Wright
Reference: Cell Rep. 2015 Nov 17;13(7):1481-92. doi: 10.1016/j.celrep.2015.10.018.
PMID: 26549450

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tags: 2015, Antibiotic Adjuvants
Tuesday 11.17.15
Posted by Wright Lab
 

Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance. →

Authors: Andrew M King, Sarah A Reid-Yu, Wenliang Wang, Dustin T King, Gianfranco De Pascale, Natalie C Strynadka, Timothy R Walsh, Brian K Coombes, Gerard D Wright
Reference: Nature. 2014 Jun 26;510(7506):503-6. doi: 10.1038/nature13445.
PMID: 24965651

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tags: 2014, Feature, Antibiotic Adjuvants, WAC, ARP
Thursday 06.26.14
Posted by Wright Lab
 

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