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The Wright Lab

  • Welcome
  • Lab News
  • Team
    • Gerry Wright
    • The Lab
  • Research
    • An Overview
    • Antimicrobial Discovery
    • Antibiotic Resistance
  • Publications
  • Platforms
    • Wright Actinomycete Collection
    • Wright Clinical Collection
    • Antibiotic Resistance Platform
    • The Comprehensive Antibiotic Resistance Database
  • Articles
  • Contact

Phylogeny-Informed Synthetic Biology Reveals Unprecedented Structural Novelty in Type V Glycopeptide Antibiotics →

Authors: Min Xu, Wenliang Wang, Nicholas Waglechner, Elizabeth J. Culp, Allison K. Guitor, and Gerard D. Wright.
Reference: ACS Central Science
DOI: 10.1021/acscentsci.1c01389.
PMID:

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tags: 2022, Min Xu, Wenliang Wang, Nicholas Waglechner, Beth Culp, Allison Guitor
Wednesday 04.27.22
Posted by Gerry Wright
 

Glycopeptide antibiotic discovery in the genomic era →

Authors: Xu M, Wang W, Wright GD.
Reference: Methods Enzymol.
DOI: 10.1016/bs.mie.2021.11.009. .
PMID: 35379441.

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tags: Min Xu, Wenliang Wang, 2021
Tuesday 12.21.21
Posted by Gerry Wright
 

A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity →

Authors: Alder A, Struck NS, Xu M, Johnson JW, Wang W, Pallant D, Cook MA, Rambow J, Lemcke S, Gilberger TW, Wright GD.
Reference: Cell Chem Biol.
DOI: 10.1016/j.chembiol.2021.10.005.
PMID: 34710358.

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tags: 2021, Min Xu, Wenliang Wang, Daniel Pallant, Michael Cook
Saturday 10.23.21
Posted by Gerry Wright
 

Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics →

Authors: Benoit YD, Mitchell RR, Wang W, Orlando L, Boyd AL, Tanasijevic B, Aslostovar L, Shapovalova Z, Doyle M, Bergin CJ, Vojnits K, Casado FL, Di Lu J, Porras DP, García-Rodriguez JL, Russell J, Zouggar A, Masibag AN, Caba C, Koteva K, Kinthada LK, Patel JS, Andres SN, Magolan J, Collins TJ, Wright GD, Bhatia M.
Reference: Cell Chem Biol.
DOI: doi: 10.1016/j.chembiol.2021.04.014.
PMID: 33979648.

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tags: 2021, Wenliang Wang, Kalinka Koteva
Friday 05.07.21
Posted by Gerry Wright
 

GPAHex-A synthetic biology platform for Type IV-V glycopeptide antibiotic production and discovery →

Authors: Xu M, Wang W, Waglechner N, Culp EJ, Guitor AK, Wright GD.
Reference: Nat Commun.
DOI: 10.1038/s41467-020-19138-5
PMID: 33067466

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tags: 2020, Min Xu, Wenliang Wang, Nicholas Waglechner, Beth Culp, Allison Guitor, Feature, Synthetic Biology
Friday 10.16.20
Posted by Gerry Wright
 

Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling →

Authors: Culp EJ, Waglecher N, Wang W, Fiebig-Comyn AA, Hsu Y, Koteva K, Sychantha D, Coombes BK, Van Nieuwenhze MS, Brun YV and Wright GD
Reference: Nature
DOI: 10.1038/s41586-020-1990-9
PMID: 32051588

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tags: 2020, Beth Culp, Nicholas Waglechner, Wenliang Wang, Kalinka Koteva, Dave Sychantha, Feature, WAC, Novel Therapeutics
Wednesday 02.12.20
Posted by Gerry Wright
 

Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics →

Authors: Culp EJ, Yim G, Waglechner N, Wang W, Pawlowski AC and Wright GD
Reference: Nat Biotechnol.
DOI: 10.1038/s41587-019-0241-9
PMID: 31501558

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tags: 2019, Beth Culp, Grace Yim, Nicholas Waglechner, Wenliang Wang, Andrew Pawlowski, WAC, Novel Therapeutics
Monday 09.09.19
Posted by Gerry Wright
 

Tri-chlorination of a teicoplanin type glycopeptide antibiotic by the halogenase StaI evades resistance →

Authors: Yim G, Wang W, Pawlowski AC, Wright GD
Reference: Antimicrob Agents Chemother
DOI: 10.1128/AAC.01540-18
PMID: 30275088

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tags: 2018, Grace Yim, Wenliang Wang, Andrew Pawlowski
Monday 10.01.18
Posted by Gerry Wright
 

Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function →

Authors: Robbins N, Spitzer M, Wang W, Waglechner N, Patel DJ, O'Brien JS, Ejim L, Ejim O, Tyers M, Wright GD.
Reference: Cell Chem Biol. 2016 Nov 17;23(11):1383-1394. doi: 10.1016/j.chembiol.2016.08.015.
PMID: 27746129

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tags: 2016, Novel Therapeutics, Nicholas Waglechner, Wenliang Wang, Linda Ejim
Thursday 11.17.16
Posted by Wright Lab
 

Identifying producers of antibacterial compounds by screening for antibiotic resistance →

Authors: Maulik N Thaker, Wenliang Wang, Peter Spanogiannopoulos, Nicholas Waglechner, Andrew M King, Ricardo Medina, Gerard D Wright
Reference: Nat Biotechnol. 2013 Oct;31(10):922-7. doi: 10.1038/nbt.2685.
PMID: 24056948 

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tags: 2013, Feature, Synthetic Biology, Nicholas Waglechner, Ricardo Medina, Wenliang Wang
Tuesday 10.01.13
Posted by Wright Lab
 

The comprehensive antibiotic resistance database →

Authors: Andrew G McArthur, Nicholas Waglechner, Fazmin Nizam, Austin Yan, Marisa A Azad, Alison J Baylay, Kirandeep Bhullar, Marc J Canova, Gianfranco De Pascale, Linda Ejim, Lindsay Kalan, Andrew M King, Kalinka Koteva, Mariya Morar, Michael R Mulvey, Jonathan S O'Brien, Andrew C Pawlowski, Laura JV Piddock, Peter Spanogiannopoulos, Arlene D Sutherland, Irene Tang, Patricia L Taylor, Maulik Thaker, Wenliang Wang, Marie Yan, Tennison Yu, Gerard D Wright
Reference: Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57. doi: 10.1128/AAC.00419-13
PMID: 23650175

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tags: 2013, Andrew Pawlowski, CARD, Nicholas Waglechner, Kalinka Koteva, Linda Ejim, Wenliang Wang
Monday 07.01.13
Posted by Wright Lab
 

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