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The Wright Lab

  • Welcome
  • Lab News
  • Team
    • Gerry Wright
    • The Lab
  • Research
    • An Overview
    • Antimicrobial Discovery
    • Antibiotic Resistance
  • Publications
  • Platforms
    • Wright Actinomycete Collection
    • Wright Clinical Collection
    • Antibiotic Resistance Platform
    • The Comprehensive Antibiotic Resistance Database
  • Articles
  • Contact

The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies. →

Authors: Pawlowski AC, Westman EL, Koteva K, Waglechner N, Wright GD
Reference: ISME vol 12, 885–897
DOI: 10.1038/s41396-017-0017-5
PMID: 29259290

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tags: Kalinka Koteva, Nicholas Waglechner, Andrew Pawlowski, Antibiotic Resistome, 2017
Tuesday 12.19.17
Posted by Gerry Wright
 

Transformation of the anticancer drug doxorubicin in the human gut microbiome →

Authors: A Yan, E Culp, J Perry, J Lau, L MacNeil, MG Surette, GD Wright
Reference: ACS Infectious Disease (Available online November 21 2017) 
DOI: 10.1021/acsinfecdis.7b00166
PMID: 29160065

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tags: 2017, Beth Culp
Tuesday 11.21.17
Posted by Wright Lab
 

Inhibitors of metallo-β-lactamases. →

Authors: CM Rotondo and GD Wright
Reference: Current Opinion in Microbiology 2017 39: 96-105
PMID: 29154026

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tags: 2017, Caitlyn Rotondo, Antibiotic Adjuvants
Thursday 11.16.17
Posted by Wright Lab
 

Probing the Interaction of Aspergillomarasmine A with Metallo-β-lactamases NDM-1, VIM-2, and IMP-7. →

Authors: Bergstrom A, Katko A, Adkins Z, Hill J, Cheng Z, Burnett M, Yang H, Aitha M, Mehaffey MR, Brodbelt JS, Tehrani KHME, Martin NI, Bonomo RA, Page RC, Tierney DL, Fast W, Wright GD, Crowder MW
Reference: ACS Infectious Disease (Epub)
DOI: 10.1021/acsinfecdis.7b00106
PMID: 29091730

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tags: 2017
Thursday 11.09.17
Posted by Wright Lab
 

Exploiting the Sensitivity of Nutrient Transporter Deletion Strains in Discovery of Natural Product Antimetabolites. →

Authors: Gehrke SS, Kumar G, Yokubynas NA, Côté JP, Wang W, French S, MacNair CR, Wright GD, Brown ED.
Reference: ACS Infectious Disease (Epub) 
DOI: 10.1021/acsinfecdis.7b00149
PMID: 29069544

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tags: 2017
Wednesday 10.25.17
Posted by Wright Lab
 

Lessons from Environmental Antibiotic Resistome →

Authors: MD Surette and GD Wright
Reference: Annual Review of Microbiology Vol. 71:309-329
PMID: 28657887

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tags: 2017, Antibiotic Resistome, Matthew Surette
Thursday 09.28.17
Posted by Wright Lab
 

Antibiotic resistance: it’s bad, but why isn’t it worse?

Authors: N Waglechner and GD Wright
Reference: BMC Biology. 2017 Sep 15;15:84. doi.org/10.1186/s12915-017-0423-1
PMID: 28915805

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tags: 2017, Antibiotic Resistome, Nicholas Waglechner
Friday 09.15.17
Posted by Gerry Wright
 

Pharmacodynamics of dose-escalated 'front-loading' polymyxin B regimens against polymyxin-resistant mcr-1-harbouring Escherichia coli. →

Authors: Smith NM, Bulman ZP, Sieron AO, Bulitta JB, Holden PN, Nation RL, Li J, Wright GD, Tsuji BT. 
Reference: Journal of Antimicrobial Chemotherapy 2017 Aug 1;72(8):2297-2303
PMID: 28505268

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tags: 2017, Arthur Sieron
Tuesday 08.01.17
Posted by Wright Lab
 

Opportunities for natural products in 21st century antibiotic discovery. →

Author: GD Wright
Reference: Natural Products Reports 2017, 34, 694-701
PMID: 28569300

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tags: 2017
Saturday 07.01.17
Posted by Gerry Wright
 

CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database →

Authors: Baofeng Jia, Amogelang R. Raphenya, Brian Alcock, Nicholas Waglechner, Peiyao Guo, Kara K. Tsang, Briony A. Lago, Biren M. Dave, Sheldon Pereira, Arjun N. Sharma, Sachin Doshi, Mélanie Courtot, Raymond Lo, Laura E. Williams, Jonathan G. Frye, Tariq Elsayegh, Daim Sardar, Erin L. Westman, Andrew C. Pawlowski, Timothy A. Johnson, Fiona S.L. Brinkman, Gerard D. Wright and Andrew G. McArthur
Reference: Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573. doi: 10.1093/nar/gkw1004.
PMID: 27789705

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tags: 2017, Nicholas Waglechner, Andrew Pawlowski
Wednesday 01.04.17
Posted by Gerry Wright
 

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