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    • Gerry Wright
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The Wright Lab

  • Welcome
  • Lab News
  • Team
    • Gerry Wright
    • The Lab
  • Research
    • An Overview
    • Antimicrobial Discovery
    • Antibiotic Resistance
  • Publications
  • Platforms
    • Wright Actinomycete Collection
    • Wright Clinical Collection
    • Antibiotic Resistance Platform
    • The Comprehensive Antibiotic Resistance Database
  • Articles
  • Contact

Resistance-Guided Discovery of Elfamycin Antibiotic Producers with Antigonococcal Activity →

Authors: Yarlagadda V, Medina R, Johnson TA, Koteva KP, Cox G, Thaker MN, Wright GD.
Reference: ACS Infect Dis.
DOI: 10.1021/acsinfecdis.0c00467
PMID: 33164482

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tags: 2020, Venky Yarlagadda, Ricardo Medina, Kalinka Koteva, Georgina Cox, WAC, Novel Therapeutics
Saturday 11.07.20
Posted by Gerry Wright
 

GPAHex-A synthetic biology platform for Type IV-V glycopeptide antibiotic production and discovery →

Authors: Xu M, Wang W, Waglechner N, Culp EJ, Guitor AK, Wright GD.
Reference: Nat Commun.
DOI: 10.1038/s41467-020-19138-5
PMID: 33067466

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tags: 2020, Min Xu, Wenliang Wang, Nicholas Waglechner, Beth Culp, Allison Guitor, Feature, Synthetic Biology
Friday 10.16.20
Posted by Gerry Wright
 

Membrane interactions of non-membrane targeting antibiotics: The case of aminoglycosides, macrolides, and fluoroquinolones →

Authors: Khondker A, Bider RC, Passos-Gastaldo I, Wright GD, Rheinstädter MC.
Reference: Biochim Biophys Acta Biomembr.
DOI: 0.1016/j.bbamem.2020.183448
PMID: 32828850

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tags: 2020
Friday 08.21.20
Posted by Gerry Wright
 

COVID-19 and Antimicrobial Resistance: Parallel and Interacting Health Emergencies →

Authors: Nieuwlaat R, Mbuagbaw L, Mertz D, Burrows L, Bowdish DME, Moja L, Wright GD, Schünemann HJ.
Reference: Clin Infect Dis.
DOI: 110.1093/cid/ciaa773
PMID: 32544232

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tags: 2020
Tuesday 06.16.20
Posted by Gerry Wright
 

Antibiotic Resistance by Enzymatic Modification of Antibiotic Targets →

Authors: Schaenzer AJ and Wright GD
Reference: Trends Mol Med.
DOI: 10.1016/j.molmed.2020.05.001
PMID: 32493628

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tags: 2020, Adam Schaenzer, Resistance Mechanisms
Monday 06.01.20
Posted by Gerry Wright
 

Venturicidin A, A Membrane-active Natural Product Inhibitor of ATP synthase Potentiates Aminoglycoside Antibiotics →

Authors: Yarlagadda V, Medina R and Wright GD
Reference: Sci Rep.
DOI: 10.1038/s41598-020-64756-0
PMID: 32424122

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tags: 2020, Venky Yarlagadda, Ricardo Medina, WAC, Antibiotic Adjuvants
Monday 05.18.20
Posted by Gerry Wright
 

Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development →

Authors: Jacques S, van der Sloot AM, Huard CC, Coulombe-Huntington J, Tsao S, Tollis S, Bertomeu T, Culp EJ, Pallant D, Cook MA, Bonneil E, Thibault P, Wright GD and Tyers M.
Reference: Genetics
DOI: 10.1534/genetics.119.302851
PMID: 32094149

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tags: Beth Culp, 2020, Daniel Pallant, Michael Cook
Monday 02.24.20
Posted by Gerry Wright
 

Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling →

Authors: Culp EJ, Waglecher N, Wang W, Fiebig-Comyn AA, Hsu Y, Koteva K, Sychantha D, Coombes BK, Van Nieuwenhze MS, Brun YV and Wright GD
Reference: Nature
DOI: 10.1038/s41586-020-1990-9
PMID: 32051588

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tags: 2020, Beth Culp, Nicholas Waglechner, Wenliang Wang, Kalinka Koteva, Dave Sychantha, Feature, WAC, Novel Therapeutics
Wednesday 02.12.20
Posted by Gerry Wright
 

Suppression of β-Lactam Resistance by Aspergillomarasmine A Is Influenced by both the Metallo-β-Lactamase Target and the Antibiotic Partner →

Authors: Rotondo CM, Sychantha D, Koteva K and Wright GD
Reference: Antimicrob Agents Chemother.
DOI: 10.1128/AAC.01386-19
PMID: 31932375

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tags: 2020, Caitlyn Rotondo, Dave Sychantha, Kalinka Koteva, Feature, WAC, Antibiotic Adjuvants
Tuesday 01.14.20
Posted by Gerry Wright
 

CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database →

Authors: Alcock BP, Raphenya AR, Lau TTY, Tsang KK, Bouchard M, Edalatmand A, Huynh W, Nguyen AV, Cheng AA, Liu S, Min SY, Miroshnichenko A, Tran HK, Werfalli RE, Nasir JA, Oloni M, Speicher DJ, Florescu A, Singh B, Faltyn M, Hernandez-Koutoucheva A, Sharma AN, Bordeleau E, Pawlowski AC, Zubyk HL, Dooley D, Griffiths E, Maguire F, Winsor GL, Beiko RG, Brinkman FSL, Hsiao WWL, Domselaar GV, McArthur AG.
Reference: Nucleic Acids Res.
DOI: 10.1093/nar/gkz935
PMID: 31665441

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tags: 2020, Haley Zubyk, Emily Bordeleau, Antibiotic Resistome, CARD
Wednesday 01.08.20
Posted by Gerry Wright
 

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