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The Wright Lab

  • Welcome
  • Lab News
  • Team
    • Gerry Wright
    • The Lab
  • Research
    • An Overview
    • Antimicrobial Discovery
    • Antibiotic Resistance
  • Publications
  • Platforms
    • Wright Actinomycete Collection
    • Wright Clinical Collection
    • Antibiotic Resistance Platform
    • The Comprehensive Antibiotic Resistance Database
  • Articles
  • Contact

Resistance-Guided Discovery of Elfamycin Antibiotic Producers with Antigonococcal Activity →

Authors: Yarlagadda V, Medina R, Johnson TA, Koteva KP, Cox G, Thaker MN, Wright GD.
Reference: ACS Infect Dis.
DOI: 10.1021/acsinfecdis.0c00467
PMID: 33164482

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tags: 2020, Venky Yarlagadda, Ricardo Medina, Kalinka Koteva, Georgina Cox, WAC, Novel Therapeutics
Saturday 11.07.20
Posted by Gerry Wright
 

Antibiotic Dereplication Using the Antibiotic Resistance Platform →

Authors: Zubyk HL, Cox G and Wright GD
Reference: J Vis Exp.
DOI: 10.3791/60536
PMID: 31680676

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tags: 2019, Haley Zubyk, Georgina Cox, ARP, Resistance Mechanisms
Thursday 10.17.19
Posted by Gerry Wright
 

A Common Platform for Antibiotic Dereplication and Adjuvant Discovery →

Authors: Cox G, Sieron A, King AM, De Pascale G, Pawlowski AC, Koteva K, Wright GD.
Reference: Cell Chem Biol. 2016 Nov 29. pii: S2451-9456(16)30434-2. doi: 10.1016/j.chembiol.2016.11.011.
PMID: 28017602

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tags: 2016, Georgina Cox, Antibiotic Adjuvants, Andrew Pawlowski, Arthur Sieron, Kalinka Koteva, ARP
Tuesday 11.29.16
Posted by Wright Lab
 

Rifampin phosphotransferase is an unusual antibiotic resistance kinase →

Authors: Peter J Stogios, Georgina Cox, Peter Spanogiannopoulos, Monica C Pillon, Nicholas Waglechner, Tatiana Skarina, Kalinka Koteva, Alba Guarné, Alexei Savchenko, Gerard D Wright
Reference: Nat Commun. 2016 Apr 22;7:11343. doi: 10.1038/ncomms11343.
PMID: 27103605

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tags: 2016, Feature, Georgina Cox, Kalinka Koteva, Resistance Mechanisms, Nicholas Waglechner
Friday 04.22.16
Posted by Wright Lab
 

Structural and molecular basis for resistance to aminoglycoside antibiotics by the adenylyltransferase ANT (2 ″)-Ia →

Authors: Georgina Cox, Peter J Stogios, Alexei Savchenko, Gerard D Wright
Reference: MBio. 2015 Jan 6;6(1). pii: e02180-14. doi: 10.1128/mBio.02180-14.
PMID: 25564464

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tags: 2015, Georgina Cox, Resistance Mechanisms
Friday 02.27.15
Posted by Wright Lab
 

Inhibition of the ANT (2 ″)-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones →

Authors: Danielle R Hirsch, Georgina Cox, Michael P D’Erasmo, Tushar Shakya, Christine Meck, Noushad Mohd, Gerard D Wright, Ryan P Murelli
Reference: Bioorg Med Chem Lett. 2014 Nov 1;24(21):4943-7. doi: 10.1016/j.bmcl.2014.09.037.
PMID: 25283553 

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tags: 2014, Georgina Cox
Saturday 11.01.14
Posted by Wright Lab
 

An unusual class of anthracyclines potentiate Gram-positive antibiotics in intrinsically resistant Gram-negative bacteria →

Authors: Georgina Cox, Kalinka Koteva, Gerard D Wright
Reference: J Antimicrob Chemother. 2014 Jul;69(7):1844-55. doi: 10.1093/jac/dku057.
PMID: 24627312 

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tags: 2014, Georgina Cox, Kalinka Koteva, WAC
Thursday 03.13.14
Posted by Wright Lab
 

Intrinsic antibiotic resistance: mechanisms, origins, challenges and solutions →

Authors: Georgina Cox, Gerard D Wright
Reference: Int J Med Microbiol. 2013 Aug;303(6-7):287-92. doi: 10.1016/j.ijmm.2013.02.009.
PMID: 23499305

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tags: 2013, Georgina Cox
Saturday 08.31.13
Posted by Wright Lab
 

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