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PMID: 40781075
The Janus Effect: The Biochemical Logic of Antibiotic Resistance →
Authors: Wright, G.D.
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DOI: 10.1021/acs.biochem.4c00585
PMID: 39772429
PMID:40140562
A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome →
Authors: Jangra, M., Travin, D.Y., Aleksandrova, E.V., Kaur, M., Darwish, L., Koteva, K., Klepacki, D., Wang, W., Tiffany, M., Sokaribo, A., Coombes, B.K., Vázquez-Laslop, N., Polikanov, Y.S., Mankin A.S., & Wright, G.D.
Reference: Nature
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PMID: 40140562
Synthetic Biology Facilitates Semisynthetic Development of Type V Glycopeptide Antibiotics Targeting Vancomycin-Resistant Enterococcus →
Authors: Kalinka Koteva, Min Xu, Wenliang Wang, Aline A. Fiebig-Comyn, Michael A. Cook, Brian K. Coombes, and Gerard D. Wright
Reference: The Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.3c00633
PMID: 37315221
HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics →
Authors: Surette MD, Waglechner N, Koteva K, Wright GD.
Reference: Mol Cell.
DOI: 10.1016/j.molcel.2022.06.019.
PMID: 35907401
ClpP inhibitors are produced by a widespread family of bacterial gene clusters →
Authors: Culp EJ, Sychantha D, Hobson C, Pawlowski AC, Prehna G, Wright GD.
Reference: Nat Microbiol.
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PMID: 35246663.
A Screen of Natural Product Extracts Identifies Moenomycin as a Potent Antigonococcal Agent →
Authors: Yarlagadda V, Rao VN, Kaur M, Guitor AK, Wright GD.
Reference: ACS Infect Dis.
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PMID: 33826296.
ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin →
Authors: Bordeleau E, Stogios PJ, Evdokimova E, Koteva K, Savchenko A, Wright GD.
Reference: mBio
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PMID: 33563840
GPAHex-A synthetic biology platform for Type IV-V glycopeptide antibiotic production and discovery →
Authors: Xu M, Wang W, Waglechner N, Culp EJ, Guitor AK, Wright GD.
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PMID: 33067466
Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling →
Authors: Culp EJ, Waglecher N, Wang W, Fiebig-Comyn AA, Hsu Y, Koteva K, Sychantha D, Coombes BK, Van Nieuwenhze MS, Brun YV and Wright GD
Reference: Nature
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PMID: 32051588
Suppression of β-Lactam Resistance by Aspergillomarasmine A Is Influenced by both the Metallo-β-Lactamase Target and the Antibiotic Partner →
Authors: Rotondo CM, Sychantha D, Koteva K and Wright GD
Reference: Antimicrob Agents Chemother.
DOI: 10.1128/AAC.01386-19
PMID: 31932375
Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes →
Authors: Cox G, Ejim L, Stogios PJ, Koteva K, Bordeleau E, Sieron AO, Savchenko A, Serio AW, Krause KM, Wright GD
Reference: ACS Infectious Diseases 2018
DOI: 10.1021/acsinfecdis.8b00001
PMID: 29634241
Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action. →
Authors: Koteva K, Cox G, Kelso JK, Surette MD, Zubyk HL, Ejim L, Stogios P, Savchenko A, Sørensen, Wright GD
Reference: Cell Chemical Biology 2018 Jan 26. pii: S2451-9456(18)30031-X
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PMID: 29398560
The evolution of substrate discrimination in macrolide antibiotic resistance enzymes. →
Authors: Pawlowski AC, Stogios PJ, Koteva K, Skarina T, Evdokimova E, Savchenko A, Wright GD
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PMID: 29317655
Rifampin phosphotransferase is an unusual antibiotic resistance kinase →
Authors: Peter J Stogios, Georgina Cox, Peter Spanogiannopoulos, Monica C Pillon, Nicholas Waglechner, Tatiana Skarina, Kalinka Koteva, Alba Guarné, Alexei Savchenko, Gerard D Wright
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PMID: 27103605
Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance. →
Authors: Andrew M King, Sarah A Reid-Yu, Wenliang Wang, Dustin T King, Gianfranco De Pascale, Natalie C Strynadka, Timothy R Walsh, Brian K Coombes, Gerard D Wright
Reference: Nature. 2014 Jun 26;510(7506):503-6. doi: 10.1038/nature13445.
PMID: 24965651
Identifying producers of antibacterial compounds by screening for antibiotic resistance →
Authors: Maulik N Thaker, Wenliang Wang, Peter Spanogiannopoulos, Nicholas Waglechner, Andrew M King, Ricardo Medina, Gerard D Wright
Reference: Nat Biotechnol. 2013 Oct;31(10):922-7. doi: 10.1038/nbt.2685.
PMID: 24056948
Antibiotic resistance is ancient →
Authors: Vanessa M D’Costa, Christine E King, Lindsay Kalan, Mariya Morar, Wilson WL Sung, Carsten Schwarz, Duane Froese, Grant Zazula, Fabrice Calmels, Regis Debruyne, G Brian Golding, Hendrik N Poinar, Gerard D Wright
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PMID: 21881561