Authors: Min Xu, Wenliang Wang, Nicholas Waglechner, Elizabeth J. Culp, Allison K. Guitor, and Gerard D. Wright.
Reference: ACS Central Science
DOI: 10.1021/acscentsci.1c01389.
PMID:
ClpP inhibitors are produced by a widespread family of bacterial gene clusters →
Authors: Culp EJ, Sychantha D, Hobson C, Pawlowski AC, Prehna G, Wright GD.
Reference: Nat Microbiol.
DOI: 10.1038/s41564-022-01073-4.
PMID: 35246663.
Demonstration of the role of cell wall homeostasis in Staphylococcus aureus growth and the action of bactericidal antibiotics →
Authors: Salamaga B, Kong L, Pasquina-Lemonche L, Lafage L, von Und Zur Muhlen M, Gibson JF, Grybchuk D, Tooke AK, Panchal V, Culp EJ, Tatham E, O'Kane ME, Catley TE, Renshaw SA, Wright GD, Plevka P, Bullough PA, Han A, Hobbs JK, Foster SJ.
Reference: Proc Natl Acad Sci U S A
DOI: 10.1073/pnas.2106022118.
PMID: 34716264.
GPAHex-A synthetic biology platform for Type IV-V glycopeptide antibiotic production and discovery →
Authors: Xu M, Wang W, Waglechner N, Culp EJ, Guitor AK, Wright GD.
Reference: Nat Commun.
DOI: 10.1038/s41467-020-19138-5
PMID: 33067466
Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development →
Authors: Jacques S, van der Sloot AM, Huard CC, Coulombe-Huntington J, Tsao S, Tollis S, Bertomeu T, Culp EJ, Pallant D, Cook MA, Bonneil E, Thibault P, Wright GD and Tyers M.
Reference: Genetics
DOI: 10.1534/genetics.119.302851
PMID: 32094149
Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling →
Authors: Culp EJ, Waglecher N, Wang W, Fiebig-Comyn AA, Hsu Y, Koteva K, Sychantha D, Coombes BK, Van Nieuwenhze MS, Brun YV and Wright GD
Reference: Nature
DOI: 10.1038/s41586-020-1990-9
PMID: 32051588
The ADEP Biosynthetic Gene Cluster in Streptomyces hawaiiensis NRRL 15010 Reveals an Accessory clpP Gene as a Novel Antibiotic Resistance Factor →
Authors: Thomy D, Culp E, Adamek M, Cheng EY, Ziemert N, Wright GD, Sass P and Brötz-Oesterhelt H.
Reference: Appl Environ Microbiol.
DOI: 10.1128/AEM.01292-19
PMID: 31399403
Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics →
Authors: Culp EJ, Yim G, Waglechner N, Wang W, Pawlowski AC and Wright GD
Reference: Nat Biotechnol.
DOI: 10.1038/s41587-019-0241-9
PMID: 31501558
Transformation of the anticancer drug doxorubicin in the human gut microbiome →
Authors: A Yan, E Culp, J Perry, J Lau, L MacNeil, MG Surette, GD Wright
Reference: ACS Infectious Disease (Available online November 21 2017)
DOI: 10.1021/acsinfecdis.7b00166
PMID: 29160065
Bacterial proteases, untapped antimicrobial drug targets. →
Authors: E Culp, GD Wright
Reference: Journal of Antibiotics (Tokyo) April; 70(4) 366-377
PMID: 27899793