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    • Gerry Wright
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The Wright Lab

  • Welcome
  • Lab News
  • Team
    • Gerry Wright
    • The Lab
  • Research
    • An Overview
    • Antimicrobial Discovery
    • Antibiotic Resistance
  • Publications
  • Platforms
    • Wright Actinomycete Collection
    • Wright Clinical Collection
    • Antibiotic Resistance Platform
    • The Comprehensive Antibiotic Resistance Database
  • Articles
  • Contact

Phylogeny-Informed Synthetic Biology Reveals Unprecedented Structural Novelty in Type V Glycopeptide Antibiotics →

Authors: Min Xu, Wenliang Wang, Nicholas Waglechner, Elizabeth J. Culp, Allison K. Guitor, and Gerard D. Wright.
Reference: ACS Central Science
DOI: 10.1021/acscentsci.1c01389.
PMID:

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tags: 2022, Min Xu, Wenliang Wang, Nicholas Waglechner, Beth Culp, Allison Guitor
Wednesday 04.27.22
Posted by Gerry Wright
 

ClpP inhibitors are produced by a widespread family of bacterial gene clusters →

Authors: Culp EJ, Sychantha D, Hobson C, Pawlowski AC, Prehna G, Wright GD.
Reference: Nat Microbiol.
DOI: 10.1038/s41564-022-01073-4.
PMID: 35246663.

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tags: 2022, Feature, Beth Culp, Dave Sychantha, Christian Hobson, Andrew Pawlowski
Friday 03.04.22
Posted by Gerry Wright
 

Demonstration of the role of cell wall homeostasis in Staphylococcus aureus growth and the action of bactericidal antibiotics →

Authors: Salamaga B, Kong L, Pasquina-Lemonche L, Lafage L, von Und Zur Muhlen M, Gibson JF, Grybchuk D, Tooke AK, Panchal V, Culp EJ, Tatham E, O'Kane ME, Catley TE, Renshaw SA, Wright GD, Plevka P, Bullough PA, Han A, Hobbs JK, Foster SJ.
Reference: Proc Natl Acad Sci U S A
DOI: 10.1073/pnas.2106022118.
PMID: 34716264.

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tags: 2021, Beth Culp
Tuesday 11.02.21
Posted by Gerry Wright
 

GPAHex-A synthetic biology platform for Type IV-V glycopeptide antibiotic production and discovery →

Authors: Xu M, Wang W, Waglechner N, Culp EJ, Guitor AK, Wright GD.
Reference: Nat Commun.
DOI: 10.1038/s41467-020-19138-5
PMID: 33067466

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tags: 2020, Min Xu, Wenliang Wang, Nicholas Waglechner, Beth Culp, Allison Guitor, Feature, Synthetic Biology
Friday 10.16.20
Posted by Gerry Wright
 

Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development →

Authors: Jacques S, van der Sloot AM, Huard CC, Coulombe-Huntington J, Tsao S, Tollis S, Bertomeu T, Culp EJ, Pallant D, Cook MA, Bonneil E, Thibault P, Wright GD and Tyers M.
Reference: Genetics
DOI: 10.1534/genetics.119.302851
PMID: 32094149

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tags: Beth Culp, 2020, Daniel Pallant, Michael Cook
Monday 02.24.20
Posted by Gerry Wright
 

Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling →

Authors: Culp EJ, Waglecher N, Wang W, Fiebig-Comyn AA, Hsu Y, Koteva K, Sychantha D, Coombes BK, Van Nieuwenhze MS, Brun YV and Wright GD
Reference: Nature
DOI: 10.1038/s41586-020-1990-9
PMID: 32051588

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tags: 2020, Beth Culp, Nicholas Waglechner, Wenliang Wang, Kalinka Koteva, Dave Sychantha, Feature, WAC, Novel Therapeutics
Wednesday 02.12.20
Posted by Gerry Wright
 

The ADEP Biosynthetic Gene Cluster in Streptomyces hawaiiensis NRRL 15010 Reveals an Accessory clpP Gene as a Novel Antibiotic Resistance Factor →

Authors: Thomy D, Culp E, Adamek M, Cheng EY, Ziemert N, Wright GD, Sass P and Brötz-Oesterhelt H.
Reference: Appl Environ Microbiol.
DOI: 10.1128/AEM.01292-19
PMID: 31399403

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tags: 2019, Beth Culp, Resistance Mechanisms
Tuesday 10.15.19
Posted by Gerry Wright
 

Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics →

Authors: Culp EJ, Yim G, Waglechner N, Wang W, Pawlowski AC and Wright GD
Reference: Nat Biotechnol.
DOI: 10.1038/s41587-019-0241-9
PMID: 31501558

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tags: 2019, Beth Culp, Grace Yim, Nicholas Waglechner, Wenliang Wang, Andrew Pawlowski, WAC, Novel Therapeutics
Monday 09.09.19
Posted by Gerry Wright
 

Transformation of the anticancer drug doxorubicin in the human gut microbiome →

Authors: A Yan, E Culp, J Perry, J Lau, L MacNeil, MG Surette, GD Wright
Reference: ACS Infectious Disease (Available online November 21 2017) 
DOI: 10.1021/acsinfecdis.7b00166
PMID: 29160065

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tags: 2017, Beth Culp
Tuesday 11.21.17
Posted by Wright Lab
 

Bacterial proteases, untapped antimicrobial drug targets. →

Authors: E Culp, GD Wright
Reference: Journal of Antibiotics (Tokyo) April; 70(4) 366-377
PMID: 27899793

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tags: Beth Culp, 2016
Wednesday 11.30.16
Posted by Wright Lab
 

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