Authors: Surette MD, Waglechner N, Koteva K, Wright GD.
Reference: Mol Cell.
DOI: 10.1016/j.molcel.2022.06.019.
PMID: 35907401
Phylogeny-Informed Synthetic Biology Reveals Unprecedented Structural Novelty in Type V Glycopeptide Antibiotics →
Authors: Min Xu, Wenliang Wang, Nicholas Waglechner, Elizabeth J. Culp, Allison K. Guitor, and Gerard D. Wright.
Reference: ACS Central Science
DOI: 10.1021/acscentsci.1c01389.
PMID:
GPAHex-A synthetic biology platform for Type IV-V glycopeptide antibiotic production and discovery →
Authors: Xu M, Wang W, Waglechner N, Culp EJ, Guitor AK, Wright GD.
Reference: Nat Commun.
DOI: 10.1038/s41467-020-19138-5
PMID: 33067466
Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling →
Authors: Culp EJ, Waglecher N, Wang W, Fiebig-Comyn AA, Hsu Y, Koteva K, Sychantha D, Coombes BK, Van Nieuwenhze MS, Brun YV and Wright GD
Reference: Nature
DOI: 10.1038/s41586-020-1990-9
PMID: 32051588
Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics →
Authors: Culp EJ, Yim G, Waglechner N, Wang W, Pawlowski AC and Wright GD
Reference: Nat Biotechnol.
DOI: 10.1038/s41587-019-0241-9
PMID: 31501558
Phylogenetic reconciliation reveals the natural history of glycopeptide antibiotic biosynthesis and resistance →
Authors: Waglechner N, McArthur AG, and Wright GD
Reference: Nat Microbiol.
DOI: 10.1038/s41564-019-0531-5
PMID: 31406334
The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies. →
Authors: Pawlowski AC, Westman EL, Koteva K, Waglechner N, Wright GD
Reference: ISME vol 12, 885–897
DOI: 10.1038/s41396-017-0017-5
PMID: 29259290
Antibiotic resistance: it’s bad, but why isn’t it worse?
Authors: N Waglechner and GD Wright
Reference: BMC Biology. 2017 Sep 15;15:84. doi.org/10.1186/s12915-017-0423-1
PMID: 28915805
CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database →
Authors: Baofeng Jia, Amogelang R. Raphenya, Brian Alcock, Nicholas Waglechner, Peiyao Guo, Kara K. Tsang, Briony A. Lago, Biren M. Dave, Sheldon Pereira, Arjun N. Sharma, Sachin Doshi, Mélanie Courtot, Raymond Lo, Laura E. Williams, Jonathan G. Frye, Tariq Elsayegh, Daim Sardar, Erin L. Westman, Andrew C. Pawlowski, Timothy A. Johnson, Fiona S.L. Brinkman, Gerard D. Wright and Andrew G. McArthur
Reference: Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573. doi: 10.1093/nar/gkw1004.
PMID: 27789705
Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function →
Authors: Robbins N, Spitzer M, Wang W, Waglechner N, Patel DJ, O'Brien JS, Ejim L, Ejim O, Tyers M, Wright GD.
Reference: Cell Chem Biol. 2016 Nov 17;23(11):1383-1394. doi: 10.1016/j.chembiol.2016.08.015.
PMID: 27746129
The Prehistory of Antibiotic Resistance →
Authors: J Perry, N Waglechner, G Wright
Reference: Cold Spring Harbor perspectives in medicine 6 (6), a025197
PMID: 27252395
Rifampin phosphotransferase is an unusual antibiotic resistance kinase →
Authors: Peter J Stogios, Georgina Cox, Peter Spanogiannopoulos, Monica C Pillon, Nicholas Waglechner, Tatiana Skarina, Kalinka Koteva, Alba Guarné, Alexei Savchenko, Gerard D Wright
Reference: Nat Commun. 2016 Apr 22;7:11343. doi: 10.1038/ncomms11343.
PMID: 27103605
Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium →
Authors: Luca Freschi, Julie Jeukens, Irena Kukavica-Ibrulj, Brian Boyle, Marie-Josée Dupont, Jérôme Laroche, Stéphane Larose, Halim Maaroufi, Joanne L Fothergill, Matthew Moore, Geoffrey L Winsor, Shawn D Aaron, Jean Barbeau, Scott C Bell, Jane L Burns, Miguel Camara, André Cantin, Steve J Charette, Ken Dewar, Éric Déziel, Keith Grimwood, Robert EW Hancock, Joe J Harrison, Stephan Heeb, Lars Jelsbak, Baofeng Jia, Dervla T Kenna, Timothy J Kidd, Jens Klockgether, Joseph S Lam, Iain L Lamont, Shawn Lewenza, Nick Loman, François Malouin, Jim Manos, Andrew G McArthur, Josie McKeown, Julie Milot, Hardeep Naghra, Dao Nguyen, Sheldon K Pereira, Gabriel G Perron, Jean-Paul Pirnay, Paul B Rainey, Simon Rousseau, Pedro M Santos, Anne Stephenson, Véronique Taylor, Jane F Turton, Nicholas Waglechner, Paul Williams, Sandra W Thrane, Gerard D Wright, Fiona SL Brinkman, Nicholas P Tucker, Burkhard Tümmler, Craig Winstanley, Roger C Levesque
Reference: Front Microbiol. 2015 Sep 29;6:1036. doi: 10.3389/fmicb.2015.01036
PMID: 26483767
Vancomycin-variable enterococci can give rise to constitutive resistance during antibiotic therapy →
Authors: Maulik N Thaker, Lindsay Kalan, Nicholas Waglechner, Alireza Eshaghi, Samir N Patel, Susan Poutanen, Barbara Willey, Bryan Coburn, Allison McGeer, Donald E Low, Gerard D Wright
Reference: Antimicrob Agents Chemother. 2015 Mar;59(3):1405-10. doi: 10.1128/AAC.04490-14.
PMID: 25512425
Harnessing the Synthetic Capabilities of Glycopeptide Antibiotic Tailoring Enzymes: Characterization of the UK‐68,597 Biosynthetic Cluster →
Authors: Grace Yim, Lindsay Kalan, Kalinka Koteva, Maulik N Thaker, Nicholas Waglechner, Irene Tang, Gerard D Wright
Reference: Chembiochem. 2014 Nov 24;15(17):2613-23. doi: 10.1002/cbic.201402179.
PMID: 25255985
Antibiotic resistance–mediated isolation of scaffold-specific natural product producers →
Authors: Maulik N Thaker, Nicholas Waglechner and Gerry D Wright
Reference: Nature Protocols 9, 1469–1479 (2014) doi:10.1038/nprot.2014.093
PMID: 24874813
A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria →
Authors: Peter Spanogiannopoulos, Nicholas Waglechner, Kalinka Koteva, Gerard D Wright
Reference: Proc Natl Acad Sci U S A. 2014 May 13;111(19):7102-7. doi: 10.1073/pnas.1402358111
PMID: 24778229
Draft genome sequence of the sulfonamide antibiotic-degrading Microbacterium sp. strain C448 →
Authors: Fabrice Martin-Laurent, Romain Marti, Nicholas Waglechner, Gerard D Wright, Edward Topp
Reference: Genome Announc. 2014 Feb 13;2(1). pii: e01113-13. doi: 10.1128/genomeA.01113-13.
PMID: 24526651
A cryptic polyene biosynthetic gene cluster in Streptomyces calvus is expressed upon complementation with a functional bldA gene →
Authors: Lindsay Kalan, Arne Gessner, Maulik N Thaker, Nicholas Waglechner, XiMing Zhu, Anjuli Szawiola, Andreas Bechthold, Gerard D Wright, David L Zechel
Reference: Chem Biol. 2013 Oct 24;20(10):1214-24. doi: 10.1016/j.chembiol.2013.09.006.
PMID: 24120331
Identifying producers of antibacterial compounds by screening for antibiotic resistance →
Authors: Maulik N Thaker, Wenliang Wang, Peter Spanogiannopoulos, Nicholas Waglechner, Andrew M King, Ricardo Medina, Gerard D Wright
Reference: Nat Biotechnol. 2013 Oct;31(10):922-7. doi: 10.1038/nbt.2685.
PMID: 24056948