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The Wright Lab

  • Welcome
  • Lab News
  • Team
    • Gerry Wright
    • The Lab
  • Research
    • An Overview
    • Antimicrobial Discovery
    • Antibiotic Resistance
  • Publications
  • Platforms
    • Wright Actinomycete Collection
    • Wright Clinical Collection
    • Antibiotic Resistance Platform
    • The Comprehensive Antibiotic Resistance Database
  • Articles
  • Contact

Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics →

Authors: Culp EJ, Yim G, Waglechner N, Wang W, Pawlowski AC and Wright GD
Reference: Nat Biotechnol.
DOI: 10.1038/s41587-019-0241-9
PMID: 31501558

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tags: 2019, Beth Culp, Grace Yim, Nicholas Waglechner, Wenliang Wang, Andrew Pawlowski, WAC, Novel Therapeutics
Monday 09.09.19
Posted by Gerry Wright
 

Tri-chlorination of a teicoplanin type glycopeptide antibiotic by the halogenase StaI evades resistance →

Authors: Yim G, Wang W, Pawlowski AC, Wright GD
Reference: Antimicrob Agents Chemother
DOI: 10.1128/AAC.01540-18
PMID: 30275088

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tags: 2018, Grace Yim, Wenliang Wang, Andrew Pawlowski
Monday 10.01.18
Posted by Gerry Wright
 

Catalytic promiscuity of glycopeptide N-methyltransferases enables bio-orthogonal labelling of biosynthetic intermediates →

Authors: Brieke C, Yim G, Peschke M, Wright GD, Cryle MJ.
Reference: Chem Commun (Camb). 2016 Nov 17;52(94):13679-13682.
PMID: 27812569

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tags: Grace Yim, 2016
Tuesday 11.01.16
Posted by Gerry Wright
 

How To Make a Glycopeptide: A Synthetic Biology Approach To Expand Antibiotic Chemical Diversity →

Authors: G Yim, W Wang, MN Thaker, S Tan, GD Wright
Reference: ACS Infect. Dis., 2016, 2 (9), pp 642–650 DOI: 10.1021/acsinfecdis.6b00105

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tags: 2016, Grace Yim, Synthetic Biology
Friday 08.05.16
Posted by Wright Lab
 

Biosynthesis of the Fluorinated Natural Product Nucleocidin in Streptomyces calvus Is Dependent on the bldA‐Specified Leu‐tRNAUUA Molecule →

Authors: Xi Ming Zhu, Stefanie Hackl, Maulik N Thaker, Lindsay Kalan, Claudia Weber, Dagmar S Urgast, Eva M Krupp, Alyssa Brewer, Stephanie Vanner, Anjuli Szawiola, Grace Yim, Jörg Feldmann, Andreas Bechthold, Gerard D Wright, David L Zechel
Reference: Chembiochem. 2015 Nov;16(17):2498-506. doi: 10.1002/cbic.201500402
PMID: 26374477

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tags: 2015, Grace Yim
Sunday 11.01.15
Posted by Wright Lab
 

Minimum information about a biosynthetic gene cluster →

Authors: Marnix H Medema, Renzo Kottmann, Pelin Yilmaz, Matthew Cummings, John B Biggins, Kai Blin, Irene De Bruijn, Yit Heng Chooi, Jan Claesen, R Cameron Coates, Pablo Cruz-Morales, Srikanth Duddela, Stephanie Düsterhus, Daniel J Edwards, David P Fewer, Neha Garg, Christoph Geiger, Juan Pablo Gomez-Escribano, Anja Greule, Michalis Hadjithomas, Anthony S Haines, Eric JN Helfrich, Matthew L Hillwig, Keishi Ishida, Adam C Jones, Carla S Jones, Katrin Jungmann, Carsten Kegler, Hyun Uk Kim, Peter Kötter, Daniel Krug, Joleen Masschelein, Alexey V Melnik, Simone M Mantovani, Emily A Monroe, Marcus Moore, Nathan Moss, Hans-Wilhelm Nützmann, Guohui Pan, Amrita Pati, Daniel Petras, F Jerry Reen, Federico Rosconi, Zhe Rui, Zhenhua Tian, Nicholas J Tobias, Yuta Tsunematsu, Philipp Wiemann, Elizabeth Wyckoff, Xiaohui Yan, Grace Yim, Fengan Yu, Yunchang Xie, Bertrand Aigle, Alexander K Apel, Carl J Balibar, Emily P Balskus, Francisco Barona-Gómez, Andreas Bechthold, Helge B Bode, Rainer Borriss, Sean F Brady, Axel A Brakhage, Patrick Caffrey, Yi-Qiang Cheng, Jon Clardy, Russell J Cox, René De Mot, Stefano Donadio, Mohamed S Donia, Wilfred A van der Donk, Pieter C Dorrestein, Sean Doyle, Arnold JM Driessen, Monika Ehling-Schulz, Karl-Dieter Entian, Michael A Fischbach, Lena Gerwick, William H Gerwick, Harald Gross, Bertolt Gust, Christian Hertweck, Monica Höfte, Susan E Jensen, Jianhua Ju, Leonard Katz, Leonard Kaysser, Jonathan L Klassen, Nancy P Keller, Jan Kormanec, Oscar P Kuipers, Tomohisa Kuzuyama, Nikos C Kyrpides, Hyung-Jin Kwon, Sylvie Lautru, Rob Lavigne, Chia Y Lee, Bai Linquan, Xinyu Liu, Wen Liu, Andriy Luzhetskyy, Taifo Mahmud, Yvonne Mast, Carmen Méndez, Mikko Metsä-Ketelä, Jason Micklefield, Douglas A Mitchell, Bradley S Moore, Leonilde M Moreira, Rolf Müller, Brett A Neilan, Markus Nett, Jens Nielsen, Fergal O'Gara, Hideaki Oikawa, Anne Osbourn, Marcia S Osburne, Bohdan Ostash, Shelley M Payne, Jean-Luc Pernodet, Miroslav Petricek, Jörn Piel, Olivier Ploux, Jos M Raaijmakers, José A Salas, Esther K Schmitt, Barry Scott, Ryan F Seipke, Ben Shen, David H Sherman, Kaarina Sivonen, Michael J Smanski, Margherita Sosio, Evi Stegmann, Roderich D Süssmuth, Kapil Tahlan, Christopher M Thomas, Yi Tang, Andrew W Truman, Muriel Viaud, Jonathan D Walton, Christopher T Walsh, Tilmann Weber, Gilles P Van Wezel, Barrie Wilkinson, Joanne M Willey, Wolfgang Wohlleben, Gerard D Wright, Nadine Ziemert, Changsheng Zhang
Reference: Nat Chem Biol. 2015 Sep;11(9):625-31. doi: 10.1038/nchembio.
PMID: 26284661

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tags: 2015, Grace Yim
Tuesday 09.01.15
Posted by Wright Lab
 

Harnessing the Synthetic Capabilities of Glycopeptide Antibiotic Tailoring Enzymes: Characterization of the UK‐68,597 Biosynthetic Cluster →

Authors: Grace Yim, Lindsay Kalan, Kalinka Koteva, Maulik N Thaker, Nicholas Waglechner, Irene Tang, Gerard D Wright
Reference: Chembiochem. 2014 Nov 24;15(17):2613-23. doi: 10.1002/cbic.201402179. 
PMID: 25255985 

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tags: 2014, Kalinka Koteva, Grace Yim, Nicholas Waglechner
Monday 11.24.14
Posted by Wright Lab
 

Glycopeptide antibiotic biosynthesis →

Authors: Grace Yim, Maulik N Thaker, Kalinka Koteva, Gerard Wright
Reference: J Antibiot (Tokyo). 2014 Jan;67(1):31-41. doi: 10.1038/ja.2013.117.
PMID: 24220108

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tags: 2014, Kalinka Koteva, Grace Yim
Wednesday 01.01.14
Posted by Wright Lab
 

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