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The Wright Lab

  • Welcome
  • Lab News
  • Team
    • Gerry Wright
    • The Lab
  • Research
    • An Overview
    • Antimicrobial Discovery
    • Antibiotic Resistance
  • Publications
  • Platforms
    • Wright Actinomycete Collection
    • Wright Clinical Collection
    • Antibiotic Resistance Platform
    • The Comprehensive Antibiotic Resistance Database
  • Articles
  • Contact

A Screen of Natural Product Extracts Identifies Moenomycin as a Potent Antigonococcal Agent →

Authors: Yarlagadda V, Rao VN, Kaur M, Guitor AK, Wright GD.
Reference: ACS Infect Dis.
DOI: doi: 10.1021/acsinfecdis.1c00040.
PMID: 33826296.

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tags: 2021, Allison Guitor, Manpreet Kaur, Venky Yarlagadda, Feature, WAC, Novel Therapeutics
Wednesday 04.07.21
Posted by Gerry Wright
 

Resistance-Guided Discovery of Elfamycin Antibiotic Producers with Antigonococcal Activity →

Authors: Yarlagadda V, Medina R, Johnson TA, Koteva KP, Cox G, Thaker MN, Wright GD.
Reference: ACS Infect Dis.
DOI: 10.1021/acsinfecdis.0c00467
PMID: 33164482

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tags: 2020, Venky Yarlagadda, Ricardo Medina, Kalinka Koteva, Georgina Cox, WAC, Novel Therapeutics
Saturday 11.07.20
Posted by Gerry Wright
 

Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling →

Authors: Culp EJ, Waglecher N, Wang W, Fiebig-Comyn AA, Hsu Y, Koteva K, Sychantha D, Coombes BK, Van Nieuwenhze MS, Brun YV and Wright GD
Reference: Nature
DOI: 10.1038/s41586-020-1990-9
PMID: 32051588

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tags: 2020, Beth Culp, Nicholas Waglechner, Wenliang Wang, Kalinka Koteva, Dave Sychantha, Feature, WAC, Novel Therapeutics
Wednesday 02.12.20
Posted by Gerry Wright
 

Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics →

Authors: Culp EJ, Yim G, Waglechner N, Wang W, Pawlowski AC and Wright GD
Reference: Nat Biotechnol.
DOI: 10.1038/s41587-019-0241-9
PMID: 31501558

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tags: 2019, Beth Culp, Grace Yim, Nicholas Waglechner, Wenliang Wang, Andrew Pawlowski, WAC, Novel Therapeutics
Monday 09.09.19
Posted by Gerry Wright
 

Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes →

Authors: Cox G, Ejim L, Stogios PJ, Koteva K, Bordeleau E, Sieron AO, Savchenko A, Serio AW, Krause KM, Wright GD
Reference: ACS Infectious Diseases 2018
DOI: 10.1021/acsinfecdis.8b00001
PMID: 29634241

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tags: 2018, Emily Bordeleau, Linda Ejim, Kalinka Koteva, Feature, Novel Therapeutics
Monday 06.04.18
Posted by Gerry Wright
 

Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function →

Authors: Robbins N, Spitzer M, Wang W, Waglechner N, Patel DJ, O'Brien JS, Ejim L, Ejim O, Tyers M, Wright GD.
Reference: Cell Chem Biol. 2016 Nov 17;23(11):1383-1394. doi: 10.1016/j.chembiol.2016.08.015.
PMID: 27746129

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tags: 2016, Novel Therapeutics, Nicholas Waglechner, Wenliang Wang, Linda Ejim
Thursday 11.17.16
Posted by Wright Lab
 

A macrophage-stimulating compound from a screen of microbial natural products →

Authors: Perry JA, Koteva K, Verschoor CP, Wang W, Bowdish DM, Wright GD.
Reference: J Antibiot (Tokyo). 2015 Jan;68(1):40-6. doi: 10.1038/ja.2014.83.
PMID: 24984798

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tags: 2014, Novel Therapeutics, WAC
Wednesday 07.02.14
Posted by Wright Lab
 

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