Publications — The Wright Lab

An Acetyltransferase Conferring Self-Resistance of the Producer to Lasso Peptide Antibiotic Lariocidin

Authors: Jangra, M., Travin, D.Y., Kaur, M., Hackenberger, D., Koteva, K., Polikanov, Y.S., Wright, G.D.
Reference: ACS Infect Dis.
DOI: 10.1021/acsinfecdis.5c00885
PMID: 41532636

Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi

Authors: Chen, X., Duan, H.D., Hoy, M.J., Koteva, K., Spitzer, M., Guitor, A.K., Puumala, E., Fiebig, A.A., Hu, G., Yiu, B., Chou, S., Bian, Z., Choi, Y., Ya Guo, A.B., Wang, W., Sun, S., Robbins, N., Averette, A.F., Cook, M.A., Truant, R., MacNeil, L.T., Brown, E.D., Kronstad, J.W., Coombes, B.K., Cowen, L.E., Heitman, J., Li, H., Wright, G.D.
Reference: Cell
DOI: 10.1016/j.cell.2025.11.036
PMID: 41478284

$Coniontins, lipopetaibiotics active against Candida auris identified from a microbial natural product fractionation library$

Coniontins, lipopetaibiotics active against Candida auris identified from a microbial natural product fractionation library

Authors: Chen, X., Koteva, K., Chou, S., Guitor, A., Pallant, D., Lee, Y., Sychantha, D., French, S., Hackenberger, D., Robbins, N., Cook, M.A., Brown, E.D., MacNeil, L.T., Cowen, L.E., & Wright, G.D.
Reference: Nature Communications
DOI: 10.1038/s41467-025-62630-z
PMID: 40781075

The Janus Effect: The Biochemical Logic of Antibiotic Resistance

Authors: Wright, G.D.
Reference: Published as part of Biochemistry special issue “A Tribute to Christopher T. Walsh”
DOI: 10.1021/acs.biochem.4c00585
PMID: 39772429
PMID:40140562

A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome

Authors: Jangra, M., Travin, D.Y., Aleksandrova, E.V., Kaur, M., Darwish, L., Koteva, K., Klepacki, D., Wang, W., Tiffany, M., Sokaribo, A., Coombes, B.K., Vázquez-Laslop, N., Polikanov, Y.S., Mankin A.S., & Wright, G.D.
Reference: Nature
DOI: 10.1038/s41586-025-08723-7
PMID: 40140562

Synthetic Biology Facilitates Semisynthetic Development of Type V Glycopeptide Antibiotics Targeting Vancomycin-Resistant Enterococcus

Authors: Kalinka Koteva, Min Xu, Wenliang Wang, Aline A. Fiebig-Comyn, Michael A. Cook, Brian K. Coombes, and Gerard D. Wright
Reference: The Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.3c00633
PMID: 37315221

HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics

Authors: Surette MD, Waglechner N, Koteva K, Wright GD.
Reference: Mol Cell.
DOI: 10.1016/j.molcel.2022.06.019.
PMID: 35907401

ClpP inhibitors are produced by a widespread family of bacterial gene clusters

Authors: Culp EJ, Sychantha D, Hobson C, Pawlowski AC, Prehna G, Wright GD.
Reference: Nat Microbiol.
DOI: 10.1038/s41564-022-01073-4.
PMID: 35246663.

A Screen of Natural Product Extracts Identifies Moenomycin as a Potent Antigonococcal Agent

Authors: Yarlagadda V, Rao VN, Kaur M, Guitor AK, Wright GD.
Reference: ACS Infect Dis.
DOI: doi: 10.1021/acsinfecdis.1c00040.
PMID: 33826296.

ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin

Authors: Bordeleau E, Stogios PJ, Evdokimova E, Koteva K, Savchenko A, Wright GD.
Reference: mBio
DOI: 10.1128/mBio.02705-20
PMID: 33563840

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