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The Wright Lab

  • Welcome
  • Lab News
  • Team
    • Gerry Wright
    • The Lab
  • Research
    • An Overview
    • Antimicrobial Discovery
    • Antibiotic Resistance
  • Publications
  • Platforms
    • Wright Actinomycete Collection
    • Wright Clinical Collection
    • Antibiotic Resistance Platform
    • The Comprehensive Antibiotic Resistance Database
  • Articles
  • Contact

Featured Publications

Featured | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 1998-2009

Publications
The Janus Effect: The Biochemical Logic of Antibiotic Resistance
The Janus Effect: The Biochemical Logic of Antibiotic Resistance

Authors: Wright, G.D.
Reference: Published as part of Biochemistry special issue “A Tribute to Christopher T. Walsh”
DOI:  10.1021/acs.biochem.4c00585
PMID: 39772429
PMID:40140562

A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome
A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome

Authors: Jangra, M., Travin, D.Y., Aleksandrova, E.V., Kaur, M., Darwish, L., Koteva, K., Klepacki, D., Wang, W., Tiffany, M., Sokaribo, A., Coombes, B.K., Vázquez-Laslop, N., Polikanov, Y.S., Mankin A.S., & Wright, G.D.
Reference: Nature
DOI:  10.1038/s41586-025-08723-7
PMID: 40140562

Synthetic Biology Facilitates Semisynthetic Development of Type V Glycopeptide Antibiotics Targeting Vancomycin-Resistant Enterococcus
Synthetic Biology Facilitates Semisynthetic Development of Type V Glycopeptide Antibiotics Targeting Vancomycin-Resistant Enterococcus

Authors: Kalinka Koteva, Min Xu, Wenliang Wang, Aline A. Fiebig-Comyn, Michael A. Cook,  Brian K. Coombes, and Gerard D. Wright
Reference:  The Journal of Medicinal Chemistry
DOI:  10.1021/acs.jmedchem.3c00633
PMID: 37315221

HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics
HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics

Authors: Surette MD, Waglechner N, Koteva K, Wright GD.
Reference: Mol Cell.
DOI: 10.1016/j.molcel.2022.06.019.
PMID: 35907401

ClpP inhibitors are produced by a widespread family of bacterial gene clusters
ClpP inhibitors are produced by a widespread family of bacterial gene clusters

Authors: Culp EJ, Sychantha D, Hobson C, Pawlowski AC, Prehna G, Wright GD.
Reference: Nat Microbiol.
DOI: 10.1038/s41564-022-01073-4.
PMID: 35246663.

A Screen of Natural Product Extracts Identifies Moenomycin as a Potent Antigonococcal Agent
A Screen of Natural Product Extracts Identifies Moenomycin as a Potent Antigonococcal Agent

Authors: Yarlagadda V, Rao VN, Kaur M, Guitor AK, Wright GD.
Reference: ACS Infect Dis.
DOI: doi: 10.1021/acsinfecdis.1c00040.
PMID: 33826296.

ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin
ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin

Authors: Bordeleau E, Stogios PJ, Evdokimova E, Koteva K, Savchenko A, Wright GD.
Reference: mBio
DOI: 10.1128/mBio.02705-20
PMID: 33563840

GPAHex-A synthetic biology platform for Type IV-V glycopeptide antibiotic production and discovery
GPAHex-A synthetic biology platform for Type IV-V glycopeptide antibiotic production and discovery

Authors: Xu M, Wang W, Waglechner N, Culp EJ, Guitor AK, Wright GD.
Reference: Nat Commun.
DOI: 10.1038/s41467-020-19138-5
PMID: 33067466

Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling
Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling

Authors: Culp EJ, Waglecher N, Wang W, Fiebig-Comyn AA, Hsu Y, Koteva K, Sychantha D, Coombes BK, Van Nieuwenhze MS, Brun YV and Wright GD
Reference: Nature
DOI: 10.1038/s41586-020-1990-9
PMID: 32051588

Suppression of β-Lactam Resistance by Aspergillomarasmine A Is Influenced by both the Metallo-β-Lactamase Target and the Antibiotic Partner
Suppression of β-Lactam Resistance by Aspergillomarasmine A Is Influenced by both the Metallo-β-Lactamase Target and the Antibiotic Partner

Authors: Rotondo CM, Sychantha D, Koteva K and Wright GD
Reference: Antimicrob Agents Chemother.
DOI: 10.1128/AAC.01386-19
PMID: 31932375

 

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