• Welcome
  • Lab News
  • Team
    • Gerry Wright
    • The Lab
  • Research
    • An Overview
    • Antimicrobial Discovery
    • Antibiotic Resistance
  • Publications
  • Platforms
    • Wright Actinomycete Collection
    • Wright Clinical Collection
    • Antibiotic Resistance Platform
    • The Comprehensive Antibiotic Resistance Database
  • Articles
  • Contact

The Wright Lab

  • Welcome
  • Lab News
  • Team
    • Gerry Wright
    • The Lab
  • Research
    • An Overview
    • Antimicrobial Discovery
    • Antibiotic Resistance
  • Publications
  • Platforms
    • Wright Actinomycete Collection
    • Wright Clinical Collection
    • Antibiotic Resistance Platform
    • The Comprehensive Antibiotic Resistance Database
  • Articles
  • Contact
 
 
 

The Wright Actinomycete Collection is a collection of predominantly actinomycete strains (there
are some non-actinomycetes and some fungi), mainly isolated from soil samples gathered
from around the world. The Wright Lab uses this library to mine for chemical matter to combat antibiotic resistance. 

 

Selected Publications

Featured
A Screen of Natural Product Extracts Identifies Moenomycin as a Potent Antigonococcal Agent
April 7, 2021
A Screen of Natural Product Extracts Identifies Moenomycin as a Potent Antigonococcal Agent
April 7, 2021

Authors: Yarlagadda V, Rao VN, Kaur M, Guitor AK, Wright GD.
Reference: ACS Infect Dis.
DOI: doi: 10.1021/acsinfecdis.1c00040.
PMID: 33826296.

April 7, 2021
Resistance-Guided Discovery of Elfamycin Antibiotic Producers with Antigonococcal Activity
November 7, 2020
Resistance-Guided Discovery of Elfamycin Antibiotic Producers with Antigonococcal Activity
November 7, 2020

Authors: Yarlagadda V, Medina R, Johnson TA, Koteva KP, Cox G, Thaker MN, Wright GD.
Reference: ACS Infect Dis.
DOI: 10.1021/acsinfecdis.0c00467
PMID: 33164482

November 7, 2020
Venturicidin A, A Membrane-active Natural Product Inhibitor of ATP synthase Potentiates Aminoglycoside Antibiotics
May 18, 2020
Venturicidin A, A Membrane-active Natural Product Inhibitor of ATP synthase Potentiates Aminoglycoside Antibiotics
May 18, 2020

Authors: Yarlagadda V, Medina R and Wright GD
Reference: Sci Rep.
DOI: 10.1038/s41598-020-64756-0
PMID: 32424122

May 18, 2020
Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling
February 12, 2020
Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling
February 12, 2020

Authors: Culp EJ, Waglecher N, Wang W, Fiebig-Comyn AA, Hsu Y, Koteva K, Sychantha D, Coombes BK, Van Nieuwenhze MS, Brun YV and Wright GD
Reference: Nature
DOI: 10.1038/s41586-020-1990-9
PMID: 32051588

February 12, 2020
Suppression of β-Lactam Resistance by Aspergillomarasmine A Is Influenced by both the Metallo-β-Lactamase Target and the Antibiotic Partner
January 14, 2020
Suppression of β-Lactam Resistance by Aspergillomarasmine A Is Influenced by both the Metallo-β-Lactamase Target and the Antibiotic Partner
January 14, 2020

Authors: Rotondo CM, Sychantha D, Koteva K and Wright GD
Reference: Antimicrob Agents Chemother.
DOI: 10.1128/AAC.01386-19
PMID: 31932375

January 14, 2020
Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics
September 9, 2019
Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics
September 9, 2019

Authors: Culp EJ, Yim G, Waglechner N, Wang W, Pawlowski AC and Wright GD
Reference: Nat Biotechnol.
DOI: 10.1038/s41587-019-0241-9
PMID: 31501558

September 9, 2019
Phylogenetic reconciliation reveals the natural history of glycopeptide antibiotic biosynthesis and resistance
August 12, 2019
Phylogenetic reconciliation reveals the natural history of glycopeptide antibiotic biosynthesis and resistance
August 12, 2019

Authors: Waglechner N, McArthur AG, and Wright GD
Reference: Nat Microbiol.
DOI: 10.1038/s41564-019-0531-5
PMID: 31406334

August 12, 2019
A macrophage-stimulating compound from a screen of microbial natural products
July 2, 2014
A macrophage-stimulating compound from a screen of microbial natural products
July 2, 2014

Authors: Perry JA, Koteva K, Verschoor CP, Wang W, Bowdish DM, Wright GD.
Reference: J Antibiot (Tokyo). 2015 Jan;68(1):40-6. doi: 10.1038/ja.2014.83.
PMID: 24984798

July 2, 2014
Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance.
June 26, 2014
Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance.
June 26, 2014

Authors: Andrew M King, Sarah A Reid-Yu, Wenliang Wang, Dustin T King, Gianfranco De Pascale, Natalie C Strynadka, Timothy R Walsh, Brian K Coombes, Gerard D Wright
Reference: Nature. 2014 Jun 26;510(7506):503-6. doi: 10.1038/nature13445.
PMID: 24965651

June 26, 2014
An unusual class of anthracyclines potentiate Gram-positive antibiotics in intrinsically resistant Gram-negative bacteria
March 13, 2014
An unusual class of anthracyclines potentiate Gram-positive antibiotics in intrinsically resistant Gram-negative bacteria
March 13, 2014

Authors: Georgina Cox, Kalinka Koteva, Gerard D Wright
Reference: J Antimicrob Chemother. 2014 Jul;69(7):1844-55. doi: 10.1093/jac/dku057.
PMID: 24627312 

March 13, 2014

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