Transformation of the anticancer drug doxorubicin in the human gut microbiome →

Authors: A Yan, E Culp, J Perry, J Lau, L MacNeil, MG Surette, GD Wright
Reference: ACS Infectious Disease (Available online November 21 2017)
DOI: 10.1021/acsinfecdis.7b00166
PMID: 29160065

Inhibitors of metallo-β-lactamases. →

Authors: CM Rotondo and GD Wright
Reference: Current Opinion in Microbiology 2017 39: 96-105
PMID: 29154026

Probing the Interaction of Aspergillomarasmine A with Metallo-β-lactamases NDM-1, VIM-2, and IMP-7. →

Authors: Bergstrom A, Katko A, Adkins Z, Hill J, Cheng Z, Burnett M, Yang H, Aitha M, Mehaffey MR, Brodbelt JS, Tehrani KHME, Martin NI, Bonomo RA, Page RC, Tierney DL, Fast W, Wright GD, Crowder MW
Reference: ACS Infectious Disease (Epub)
DOI: 10.1021/acsinfecdis.7b00106
PMID: 29091730

Exploiting the Sensitivity of Nutrient Transporter Deletion Strains in Discovery of Natural Product Antimetabolites. →

Authors: Gehrke SS, Kumar G, Yokubynas NA, Côté JP, Wang W, French S, MacNair CR, Wright GD, Brown ED.
Reference: ACS Infectious Disease (Epub)
DOI: 10.1021/acsinfecdis.7b00149
PMID: 29069544

Lessons from Environmental Antibiotic Resistome →

Authors: MD Surette and GD Wright
Reference: Annual Review of Microbiology Vol. 71:309-329
PMID: 28657887

Antibiotic resistance: it’s bad, but why isn’t it worse?

Authors: N Waglechner and GD Wright
Reference: BMC Biology. 2017 Sep 15;15:84. doi.org/10.1186/s12915-017-0423-1
PMID: 28915805

Pharmacodynamics of dose-escalated 'front-loading' polymyxin B regimens against polymyxin-resistant mcr-1-harbouring Escherichia coli. →

Authors: Smith NM, Bulman ZP, Sieron AO, Bulitta JB, Holden PN, Nation RL, Li J, Wright GD, Tsuji BT.
Reference: Journal of Antimicrobial Chemotherapy 2017 Aug 1;72(8):2297-2303
PMID: 28505268

Opportunities for natural products in 21st century antibiotic discovery. →

Author: GD Wright
Reference: Natural Products Reports 2017, 34, 694-701
PMID: 28569300

CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database →

Authors: Baofeng Jia, Amogelang R. Raphenya, Brian Alcock, Nicholas Waglechner, Peiyao Guo, Kara K. Tsang, Briony A. Lago, Biren M. Dave, Sheldon Pereira, Arjun N. Sharma, Sachin Doshi, Mélanie Courtot, Raymond Lo, Laura E. Williams, Jonathan G. Frye, Tariq Elsayegh, Daim Sardar, Erin L. Westman, Andrew C. Pawlowski, Timothy A. Johnson, Fiona S.L. Brinkman, Gerard D. Wright and Andrew G. McArthur
Reference: Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573. doi: 10.1093/nar/gkw1004.
PMID: 27789705

Evolving medicinal chemistry strategies in antibiotic discovery →

Authors: AC Pawlowski, JW Johnson, GD Wright
Reference: Curr Opin Biotechnol. 2016 Apr 23;42:108-117. doi: 10.1016/j.copbio.2016.04.006.
PMID: 27116217

A diverse intrinsic antibiotic resistome from a cave bacterium →

Authors: Pawlowski AC, Wang W, Koteva K, Barton HA, McArthur AG, Wright GD.
Reference: Nat Commun. 2016 Dec 8;7:13803. doi: 10.1038/ncomms13803.
PMID: 27929110

Bacterial proteases, untapped antimicrobial drug targets. →

Authors: E Culp, GD Wright
Reference: Journal of Antibiotics (Tokyo) April; 70(4) 366-377
PMID: 27899793

A Common Platform for Antibiotic Dereplication and Adjuvant Discovery →

Authors: Cox G, Sieron A, King AM, De Pascale G, Pawlowski AC, Koteva K, Wright GD.
Reference: Cell Chem Biol. 2016 Nov 29. pii: S2451-9456(16)30434-2. doi: 10.1016/j.chembiol.2016.11.011.
PMID: 28017602

Systematic chemical-genetic and chemical-chemical interaction datasets for prediction of compound synergism

Authors: Wildenhain J, Spitzer M, Dolma S, Jarvik N, White R, Roy M, Griffiths E, Bellows DS, Wright GD, Tyers M.
Reference: Scientific Data 3, Article number: 160095 (2016). doi:10.1038/sdata.2016.95
PMID: 2787484

Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function →

Authors: Robbins N, Spitzer M, Wang W, Waglechner N, Patel DJ, O'Brien JS, Ejim L, Ejim O, Tyers M, Wright GD.
Reference: Cell Chem Biol. 2016 Nov 17;23(11):1383-1394. doi: 10.1016/j.chembiol.2016.08.015.
PMID: 27746129

Catalytic promiscuity of glycopeptide N-methyltransferases enables bio-orthogonal labelling of biosynthetic intermediates →

Authors: Brieke C, Yim G, Peschke M, Wright GD, Cryle MJ.
Reference: Chem Commun (Camb). 2016 Nov 17;52(94):13679-13682.
PMID: 27812569

Total Synthesis of Aspergillomarasmine A and Related Compounds: A Sulfamidate Approach Enables Exploration of Structure–Activity Relationships →

Authors: SA Albu, K Koteva, AM King, S Al‐Karmi, GD Wright, A Capretta
Reference: Angew Chem Int Ed Engl. 2016 Oct 10;55(42):13259-13262. doi: 10.1002/anie.201606657.
PMID: 27633338