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    • Gerry Wright
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    • The Comprehensive Antibiotic Resistance Database
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The Wright Lab

  • Welcome
  • Lab News
  • Team
    • Gerry Wright
    • The Lab
  • Research
    • An Overview
    • Antimicrobial Discovery
    • Antibiotic Resistance
  • Publications
  • Platforms
    • Wright Actinomycete Collection
    • Wright Clinical Collection
    • Antibiotic Resistance Platform
    • The Comprehensive Antibiotic Resistance Database
  • Articles
  • Contact

A Screen of Natural Product Extracts Identifies Moenomycin as a Potent Antigonococcal Agent →

Authors: Yarlagadda V, Rao VN, Kaur M, Guitor AK, Wright GD.
Reference: ACS Infect Dis.
DOI: doi: 10.1021/acsinfecdis.1c00040.
PMID: 33826296.

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tags: 2021, Allison Guitor, Manpreet Kaur, Venky Yarlagadda, Feature, WAC, Novel Therapeutics
Wednesday 04.07.21
Posted by Gerry Wright
 

Resistance-Guided Discovery of Elfamycin Antibiotic Producers with Antigonococcal Activity →

Authors: Yarlagadda V, Medina R, Johnson TA, Koteva KP, Cox G, Thaker MN, Wright GD.
Reference: ACS Infect Dis.
DOI: 10.1021/acsinfecdis.0c00467
PMID: 33164482

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tags: 2020, Venky Yarlagadda, Ricardo Medina, Kalinka Koteva, Georgina Cox, WAC, Novel Therapeutics
Saturday 11.07.20
Posted by Gerry Wright
 

Venturicidin A, A Membrane-active Natural Product Inhibitor of ATP synthase Potentiates Aminoglycoside Antibiotics →

Authors: Yarlagadda V, Medina R and Wright GD
Reference: Sci Rep.
DOI: 10.1038/s41598-020-64756-0
PMID: 32424122

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tags: 2020, Venky Yarlagadda, Ricardo Medina, WAC, Antibiotic Adjuvants
Monday 05.18.20
Posted by Gerry Wright
 

Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling →

Authors: Culp EJ, Waglecher N, Wang W, Fiebig-Comyn AA, Hsu Y, Koteva K, Sychantha D, Coombes BK, Van Nieuwenhze MS, Brun YV and Wright GD
Reference: Nature
DOI: 10.1038/s41586-020-1990-9
PMID: 32051588

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tags: 2020, Beth Culp, Nicholas Waglechner, Wenliang Wang, Kalinka Koteva, Dave Sychantha, Feature, WAC, Novel Therapeutics
Wednesday 02.12.20
Posted by Gerry Wright
 

Suppression of β-Lactam Resistance by Aspergillomarasmine A Is Influenced by both the Metallo-β-Lactamase Target and the Antibiotic Partner →

Authors: Rotondo CM, Sychantha D, Koteva K and Wright GD
Reference: Antimicrob Agents Chemother.
DOI: 10.1128/AAC.01386-19
PMID: 31932375

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tags: 2020, Caitlyn Rotondo, Dave Sychantha, Kalinka Koteva, Feature, WAC, Antibiotic Adjuvants
Tuesday 01.14.20
Posted by Gerry Wright
 

Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics →

Authors: Culp EJ, Yim G, Waglechner N, Wang W, Pawlowski AC and Wright GD
Reference: Nat Biotechnol.
DOI: 10.1038/s41587-019-0241-9
PMID: 31501558

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tags: 2019, Beth Culp, Grace Yim, Nicholas Waglechner, Wenliang Wang, Andrew Pawlowski, WAC, Novel Therapeutics
Monday 09.09.19
Posted by Gerry Wright
 

Phylogenetic reconciliation reveals the natural history of glycopeptide antibiotic biosynthesis and resistance →

Authors: Waglechner N, McArthur AG, and Wright GD
Reference: Nat Microbiol.
DOI: 10.1038/s41564-019-0531-5
PMID: 31406334

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tags: 2019, Nicholas Waglechner, WAC, Evolution of Resistance
Monday 08.12.19
Posted by Gerry Wright
 

A macrophage-stimulating compound from a screen of microbial natural products →

Authors: Perry JA, Koteva K, Verschoor CP, Wang W, Bowdish DM, Wright GD.
Reference: J Antibiot (Tokyo). 2015 Jan;68(1):40-6. doi: 10.1038/ja.2014.83.
PMID: 24984798

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tags: 2014, Novel Therapeutics, WAC
Wednesday 07.02.14
Posted by Wright Lab
 

Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance. →

Authors: Andrew M King, Sarah A Reid-Yu, Wenliang Wang, Dustin T King, Gianfranco De Pascale, Natalie C Strynadka, Timothy R Walsh, Brian K Coombes, Gerard D Wright
Reference: Nature. 2014 Jun 26;510(7506):503-6. doi: 10.1038/nature13445.
PMID: 24965651

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tags: 2014, Feature, Antibiotic Adjuvants, WAC, ARP
Thursday 06.26.14
Posted by Wright Lab
 

An unusual class of anthracyclines potentiate Gram-positive antibiotics in intrinsically resistant Gram-negative bacteria →

Authors: Georgina Cox, Kalinka Koteva, Gerard D Wright
Reference: J Antimicrob Chemother. 2014 Jul;69(7):1844-55. doi: 10.1093/jac/dku057.
PMID: 24627312 

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tags: 2014, Georgina Cox, Kalinka Koteva, WAC
Thursday 03.13.14
Posted by Wright Lab
 

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