Authors: Zubyk HL, Cox G and Wright GD
Reference: J Vis Exp.
DOI: 10.3791/60536
PMID: 31680676
The ADEP Biosynthetic Gene Cluster in Streptomyces hawaiiensis NRRL 15010 Reveals an Accessory clpP Gene as a Novel Antibiotic Resistance Factor →
Authors: Thomy D, Culp E, Adamek M, Cheng EY, Ziemert N, Wright GD, Sass P and Brötz-Oesterhelt H.
Reference: Appl Environ Microbiol.
DOI: 10.1128/AEM.01292-19
PMID: 31399403
Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics →
Authors: Culp EJ, Yim G, Waglechner N, Wang W, Pawlowski AC and Wright GD
Reference: Nat Biotechnol.
DOI: 10.1038/s41587-019-0241-9
PMID: 31501558
Phylogenetic reconciliation reveals the natural history of glycopeptide antibiotic biosynthesis and resistance →
Authors: Waglechner N, McArthur AG, and Wright GD
Reference: Nat Microbiol.
DOI: 10.1038/s41564-019-0531-5
PMID: 31406334
Environmental and clinical antibiotic resistomes, same only different →
Authors: Wright GD
Reference: Curr Opin Microbiol.
DOI: 10.1016/j.mib.2019.06.005
PMID: 31330416
Drug combinations: a strategy to extend the life of antibiotics in the 21st century →
Authors: Tyers M and Wright GD
Reference: Nat Reviews Microbiol.
DOI: 10.1038/s41579-018-0141-x
PMID: 30683887
Unlocking the Potential of Natural Products in Drug Discovery →
Authors: Wright GD
Reference: Microb. Biotechnol.
DOI: 10.1111/1751-7915.13351
PMID: 30565871
Heterologous expression-facilitated natural products’ discovery in actinomycetes →
Authors: Xu M, Wright GD
Reference: J Ind Microbiol Biotechnol.
DOI: 10.1007/s10295-018-2097-2
PMID: 30446891
Antimicrobial Resistance and Respiratory Infections →
Authors: Guitor AK, Wright GD
Reference: Chest
DOI: 10.1016/j.chest.2018.06.019
PMID: 29959904
Tri-chlorination of a teicoplanin type glycopeptide antibiotic by the halogenase StaI evades resistance →
Authors: Yim G, Wang W, Pawlowski AC, Wright GD
Reference: Antimicrob Agents Chemother
DOI: 10.1128/AAC.01540-18
PMID: 30275088
Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes →
Authors: Cox G, Ejim L, Stogios PJ, Koteva K, Bordeleau E, Sieron AO, Savchenko A, Serio AW, Krause KM, Wright GD
Reference: ACS Infectious Diseases 2018
DOI: 10.1021/acsinfecdis.8b00001
PMID: 29634241
Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis →
Authors: Stogios PJ, Cox G, Zubyk HL, Evdokimova E, Wawrzak Z, Wright GD, Savchenko A
Reference: ACS Chemical Biology 2018 13 (5), 1322-1332
DOI: 10.1021/acschembio.8b00116
PMID: 29631403
Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action. →
Authors: Koteva K, Cox G, Kelso JK, Surette MD, Zubyk HL, Ejim L, Stogios P, Savchenko A, Sørensen, Wright GD
Reference: Cell Chemical Biology 2018 Jan 26. pii: S2451-9456(18)30031-X
DOI: 10.1016/j.chembiol.2018.01.009.
PMID: 29398560
The evolution of substrate discrimination in macrolide antibiotic resistance enzymes. →
Authors: Pawlowski AC, Stogios PJ, Koteva K, Skarina T, Evdokimova E, Savchenko A, Wright GD
Reference: Nature Communications 2018 ;9(1):112
DOI: 10.1038/s41467-017-02680-0.
PMID: 29317655
The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies. →
Authors: Pawlowski AC, Westman EL, Koteva K, Waglechner N, Wright GD
Reference: ISME vol 12, 885–897
DOI: 10.1038/s41396-017-0017-5
PMID: 29259290
Transformation of the anticancer drug doxorubicin in the human gut microbiome →
Authors: A Yan, E Culp, J Perry, J Lau, L MacNeil, MG Surette, GD Wright
Reference: ACS Infectious Disease (Available online November 21 2017)
DOI: 10.1021/acsinfecdis.7b00166
PMID: 29160065
Inhibitors of metallo-β-lactamases. →
Authors: CM Rotondo and GD Wright
Reference: Current Opinion in Microbiology 2017 39: 96-105
PMID: 29154026
Probing the Interaction of Aspergillomarasmine A with Metallo-β-lactamases NDM-1, VIM-2, and IMP-7. →
Authors: Bergstrom A, Katko A, Adkins Z, Hill J, Cheng Z, Burnett M, Yang H, Aitha M, Mehaffey MR, Brodbelt JS, Tehrani KHME, Martin NI, Bonomo RA, Page RC, Tierney DL, Fast W, Wright GD, Crowder MW
Reference: ACS Infectious Disease (Epub)
DOI: 10.1021/acsinfecdis.7b00106
PMID: 29091730
Exploiting the Sensitivity of Nutrient Transporter Deletion Strains in Discovery of Natural Product Antimetabolites. →
Authors: Gehrke SS, Kumar G, Yokubynas NA, Côté JP, Wang W, French S, MacNair CR, Wright GD, Brown ED.
Reference: ACS Infectious Disease (Epub)
DOI: 10.1021/acsinfecdis.7b00149
PMID: 29069544
Lessons from Environmental Antibiotic Resistome →
Authors: MD Surette and GD Wright
Reference: Annual Review of Microbiology Vol. 71:309-329
PMID: 28657887