Authors: N Waglechner and GD Wright
Reference: BMC Biology. 2017 Sep 15;15:84. doi.org/10.1186/s12915-017-0423-1
PMID: 28915805
Pharmacodynamics of dose-escalated 'front-loading' polymyxin B regimens against polymyxin-resistant mcr-1-harbouring Escherichia coli. →
Authors: Smith NM, Bulman ZP, Sieron AO, Bulitta JB, Holden PN, Nation RL, Li J, Wright GD, Tsuji BT.
Reference: Journal of Antimicrobial Chemotherapy 2017 Aug 1;72(8):2297-2303
PMID: 28505268
Opportunities for natural products in 21st century antibiotic discovery. →
Author: GD Wright
Reference: Natural Products Reports 2017, 34, 694-701
PMID: 28569300
CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database →
Authors: Baofeng Jia, Amogelang R. Raphenya, Brian Alcock, Nicholas Waglechner, Peiyao Guo, Kara K. Tsang, Briony A. Lago, Biren M. Dave, Sheldon Pereira, Arjun N. Sharma, Sachin Doshi, Mélanie Courtot, Raymond Lo, Laura E. Williams, Jonathan G. Frye, Tariq Elsayegh, Daim Sardar, Erin L. Westman, Andrew C. Pawlowski, Timothy A. Johnson, Fiona S.L. Brinkman, Gerard D. Wright and Andrew G. McArthur
Reference: Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573. doi: 10.1093/nar/gkw1004.
PMID: 27789705
Evolving medicinal chemistry strategies in antibiotic discovery →
Authors: AC Pawlowski, JW Johnson, GD Wright
Reference: Curr Opin Biotechnol. 2016 Apr 23;42:108-117. doi: 10.1016/j.copbio.2016.04.006.
PMID: 27116217
A diverse intrinsic antibiotic resistome from a cave bacterium →
Authors: Pawlowski AC, Wang W, Koteva K, Barton HA, McArthur AG, Wright GD.
Reference: Nat Commun. 2016 Dec 8;7:13803. doi: 10.1038/ncomms13803.
PMID: 27929110
Bacterial proteases, untapped antimicrobial drug targets. →
Authors: E Culp, GD Wright
Reference: Journal of Antibiotics (Tokyo) April; 70(4) 366-377
PMID: 27899793
A Common Platform for Antibiotic Dereplication and Adjuvant Discovery →
Authors: Cox G, Sieron A, King AM, De Pascale G, Pawlowski AC, Koteva K, Wright GD.
Reference: Cell Chem Biol. 2016 Nov 29. pii: S2451-9456(16)30434-2. doi: 10.1016/j.chembiol.2016.11.011.
PMID: 28017602
Systematic chemical-genetic and chemical-chemical interaction datasets for prediction of compound synergism
Authors: Wildenhain J, Spitzer M, Dolma S, Jarvik N, White R, Roy M, Griffiths E, Bellows DS, Wright GD, Tyers M.
Reference: Scientific Data 3, Article number: 160095 (2016). doi:10.1038/sdata.2016.95
PMID: 2787484
Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function →
Authors: Robbins N, Spitzer M, Wang W, Waglechner N, Patel DJ, O'Brien JS, Ejim L, Ejim O, Tyers M, Wright GD.
Reference: Cell Chem Biol. 2016 Nov 17;23(11):1383-1394. doi: 10.1016/j.chembiol.2016.08.015.
PMID: 27746129
Catalytic promiscuity of glycopeptide N-methyltransferases enables bio-orthogonal labelling of biosynthetic intermediates →
Authors: Brieke C, Yim G, Peschke M, Wright GD, Cryle MJ.
Reference: Chem Commun (Camb). 2016 Nov 17;52(94):13679-13682.
PMID: 27812569
Total Synthesis of Aspergillomarasmine A and Related Compounds: A Sulfamidate Approach Enables Exploration of Structure–Activity Relationships →
Authors: SA Albu, K Koteva, AM King, S Al‐Karmi, GD Wright, A Capretta
Reference: Angew Chem Int Ed Engl. 2016 Oct 10;55(42):13259-13262. doi: 10.1002/anie.201606657.
PMID: 27633338
How To Make a Glycopeptide: A Synthetic Biology Approach To Expand Antibiotic Chemical Diversity →
Authors: G Yim, W Wang, MN Thaker, S Tan, GD Wright
Reference: ACS Infect. Dis., 2016, 2 (9), pp 642–650 DOI: 10.1021/acsinfecdis.6b00105
Antibiotic Adjuvants: Rescuing Antibiotics from Resistance →
Authors: GD Wright
Reference: Trends Microbiol. 2016 Jul 15. pii: S0966-842X(16)30072-5. doi: 10.1016/j.tim.2016.06.009.
PMID: 27430191
Combinatorial Strategies For Combating Invasive Fungal Infections →
Authors: M Spitzer, N Robbins, GD Wright
Reference: Virulence. 2016 Jun 7:1-17.
PMID: 27268286
The Prehistory of Antibiotic Resistance →
Authors: J Perry, N Waglechner, G Wright
Reference: Cold Spring Harbor perspectives in medicine 6 (6), a025197
PMID: 27252395
Rifampin phosphotransferase is an unusual antibiotic resistance kinase →
Authors: Peter J Stogios, Georgina Cox, Peter Spanogiannopoulos, Monica C Pillon, Nicholas Waglechner, Tatiana Skarina, Kalinka Koteva, Alba Guarné, Alexei Savchenko, Gerard D Wright
Reference: Nat Commun. 2016 Apr 22;7:11343. doi: 10.1038/ncomms11343.
PMID: 27103605
Beating Superbugs: Innovative Genomics and Policies to Tackle AMR →
Authors: Rainer Engelhardt, Gerard Wright
Reference: Genome Canada Policy Brief No. 11
Total Synthesis and Activity of the Metallo‐β‐lactamase Inhibitor Aspergillomarasmine A →
Authors: K Koteva, AM King, A Capretta, GD Wright
Reference: Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2210-2. doi: 10.1002/anie.201510057.
PMID: 26709849
Antibacterial drug discovery in the resistance era →
Authors: ED Brown, GD Wright
Reference: Nature. 2016 Jan 21;529(7586):336-43. doi: 10.1038/nature17042.
PMID: 26791724