Isolation of flavonoids from the heartwood and resin of Prunus avium and some preliminary biological investigations. McNulty J, Nair JJ, Bollareddy E, Keskar K, Thorat A, Crankshaw DJ, Holloway AC, Khan G, Wright GD, Ejim L. Phytochemistry. 2009 Dec;70(17-18):2040-6. PMID: 19837443.
Making sense of antisense in antibiotic drug discovery. Wright GD. Cell Host Microbe. 2009 Sep 17;6(3):197-8. PMID: 19748460.
Noncanonical vancomycin resistance cluster from Desulfitobacterium hafniense Y51. Kalan L, Ebert S, Kelly T, Wright GD. Antimicrob Agents Chemother. 2009 Jul;53(7):2841-5. PMID: 19414574.
Novel approaches to discovery of antibacterial agents. Taylor PL, Wright GD. Anim Health Res Rev. 2008 Dec;9(2):237-46. PMID: 19006597.
The wall teichoic acid polymerase TagF efficiently synthesizes poly(glycerol phosphate) on the TagB product lipid III. Pereira MP, Schertzer JW, D’Elia MA, Koteva KP, Hughes DW, Wright GD, Brown ED. Chembiochem. 2008 Jun 16;9(9):1385-90. PMID: 18465758.
Chemical biology of tetracycline antibiotics. Zakeri B, Wright GD. Biochem Cell Biol. 2008 Apr;86(2):124-36. PMID: 18443626.
Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr. Baysarowich J, Koteva K, Hughes DW, Ejim L, Griffiths E, Zhang K, Junop M, Wright GD. Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4886-91. PMID: 18349144.
Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants. Taylor PL, Blakely KM, de Leon GP, Walker JR, McArthur F, Evdokimova E, Zhang K, Valvano MA, Wright GD, Junop MS. J Biol Chem. 2008 Feb 1;283(5):2835-45. PMID: 18056714.
Expanding the soil antibiotic resistome: exploring environmental diversity. D’Costa VM, Griffiths E, Wright GD. Curr Opin Microbiol. 2007 Oct;10(5):481-9. PMID: 17951101.
On the road to bacterial cell death. Wright GD. Cell. 2007 Sep 7;130(5):781-3. PMID: 17803902.
New strategies for combating multidrug-resistant bacteria. Wright GD, Sutherland AD. Trends Mol Med. 2007 Jun;13(6):260-7. PMID: 17493872.
Role of homoserine transacetylase as a new target for antifungal agents. Nazi I, Scott A, Sham A, Rossi L, Williamson PR, Kronstad JW, Wright GD. Antimicrob Agents Chemother. 2007 May;51(5):1731-6. PMID: 17353245.
Biochemistry. A new target for antibiotic development. Wright GD. Science. 2007 Mar 9;315(5817):1373-4. PMID: 17347430.
Inhibitors of bacterial cystathionine beta-lyase: leads for new antimicrobial agents and probes of enzyme structure and function. Ejim LJ, Blanchard JE, Koteva KP, Sumerfield R, Elowe NH, Chechetto JD, Brown ED, Junop MS, Wright GD. J Med Chem. 2007 Feb 22;50(4):755-64. PMID: 17300162.
The antibiotic resistome: the nexus of chemical and genetic diversity. Wright GD. Nat Rev Microbiol. 2007 Mar;5(3):175-86. PMID: 17277795.
An in vitro screen of bacterial lipopolysaccharide biosynthetic enzymes identifies an inhibitor of ADP-heptose biosynthesis.De Leon GP, Elowe NH, Koteva KP, Valvano MA, Wright GD. Chem Biol. 2006 Apr;13(4):437-41. PMID: 16632256.
Biosynthesis of sulfated glycopeptide antibiotics by using the sulfotransferase StaL.Lamb SS, Patel T, Koteva KP, Wright GD. Chem Biol. 2006 Feb;13(2):171-81. PMID: 16492565.
Sampling the antibiotic resistome.D’Costa VM, McGrann KM, Hughes DW, Wright GD. Science. 2006 Jan 20;311(5759):374-7. PMID: 16424339.
Catalytic mechanism of fungal homoserine transacetylase.Nazi I, Wright GD. Biochemistry. 2005 Oct 18;44(41):13560-6. PMID: 16216079.
Establishing the principles of recognition in the adenine-binding region of an aminoglycoside antibiotic kinase [APH(3')-IIIa].Boehr DD, Farley AR, LaRonde FJ, Murdock TR, Wright GD, Cox JR. Biochemistry. 2005 Sep 20;44(37):12445-53. PMID: 16156657.
Tigecycline is modified by the flavin-dependent monooxygenase TetX.Moore IF, Hughes DW, Wright GD. Biochemistry. 2005 Sep 6;44(35):11829-35. PMID: 16128584.
Bacterial resistance to antibiotics: enzymatic degradation and modification.Wright GD. Adv Drug Deliv Rev. 2005 Jul 29;57(10):1451-70. PMID: 15950313.
Chimeric streptogramin-tyrocidine antibiotics that overcome streptogramin resistance.Mukhtar TA, Koteva KP, Wright GD. Chem Biol. 2005 Feb;12(2):229-35. PMID: 15734650.
New targets and screening approaches in antimicrobial drug discovery.Brown ED, Wright GD. Chem Rev. 2005 Feb;105(2):759-74. PMID: 15700964.
Streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesis.Mukhtar TA, Wright GD. Chem Rev. 2005 Feb;105(2):529-42. PMID: 15700955.
Accessorizing natural products: adding to nature’s toolbox.Lamb SS, Wright GD. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):519-20. PMID: 15647344.
Multicopy suppressors for novel antibacterial compounds reveal targets and drug efflux susceptibility. Li X, Zolli-Juran M, Cechetto JD, Daigle DM, Wright GD, Brown ED. Chem Biol. 2004 Oct;11(10):1423-30. PMID: 15489169.
TetX is a flavin-dependent monooxygenase conferring resistance to tetracycline antibiotics. Yang W, Moore IF, Koteva KP, Bareich DC, Hughes DW, Wright GD. J Biol Chem. 2004 Dec 10;279(50):52346-52. PMID: 15452119.
Domain-domain interactions in the aminoglycoside antibiotic resistance enzyme AAC(6′)-APH(2”). Boehr DD, Daigle DM, Wright GD. Biochemistry. 2004 Aug 3;43(30):9846-55. PMID: 15274639.
New phenolic inhibitors of yeast homoserine dehydrogenase. Ejim L, Mirza IA, Capone C, Nazi I, Jenkins S, Chee GL, Berghuis AM, Wright GD. Bioorg Med Chem. 2004 Jul 15;12(14):3825-30. PMID: 15210149.
Cystathionine beta-lyase is important for virulence of Salmonella enterica serovar Typhimurium. Ejim LJ, D’Costa VM, Elowe NH, Loredo-Osti JC, Malo D, Wright GD. Infect Immun. 2004 Jun;72(6):3310-4. PMID: 15155634.
Small molecule functional discrimination of the kinases required for the microbial synthesis of threonine and isoleucine. Bareich D, Koteva K, Nazi I, Wright GD. Bioorg Med Chem. 2004 Feb 15;12(4):807-15. PMID: 14759741.
Molecular mechanism of the enterococcal aminoglycoside 6′-N-acetyltransferase’: role of GNAT-conserved residues in the chemistry of antibiotic inactivation. Draker KA, Wright GD. Biochemistry. 2004 Jan 20;43(2):446-54. PMID: 14717599.
One-pot chemoenzymatic preparation of coenzyme A analogues. Nazi I, Koteva KP, Wright GD. Anal Biochem. 2004 Jan 1;324(1):100-5. PMID: 14654051.
Functionally important amino acids in Saccharomyces cerevisiae aspartate kinase. Bareich DC, Wright GD. Biochem Biophys Res Commun. 2003 Nov 21;311(3):597-603. PMID: 14623312.
Enzyme-assisted suicide: molecular basis for the antifungal activity of 5-hydroxy-4-oxonorvaline by potent inhibition of homoserine dehydrogenase. Jacques SL, Mirza IA, Ejim L, Koteva K, Hughes DW, Green K, Kinach R, Honek JF, Lai HK, Berghuis AM, Wright GD. Chem Biol. 2003 Oct;10(10):989-95. PMID: 14583265.
Simultaneous in vitro assay of the first four enzymes in the fungal aspartate pathway identifies a new class of aspartate kinase inhibitor. Bareich DC, Nazi I, Wright GD. Chem Biol. 2003 Oct;10(10):967-73. PMID: 14583263.
Mechanisms of resistance to antibiotics. Wright GD. Curr Opin Chem Biol. 2003 Oct;7(5):563-9. PMID: 14580559.
Kinetic mechanism of the GCN5-related chromosomal aminoglycoside acetyltransferase AAC(6′)-Ii from Enterococcus faecium: evidence of dimer subunit cooperativity. Draker KA, Northrop DB, Wright GD. Biochemistry. 2003 Jun 3;42(21):6565-74. PMID: 12767240.
Functional annotation of putative aminoglycoside antibiotic modifying proteins in Mycobacterium tuberculosis H37Rv. Draker KA, Boehr DD, Elowe NH, Noga TJ, Wright GD. J Antibiot (Tokyo). 2003 Feb;56(2):135-42. PMID: 12715873.
Broad-spectrum peptide inhibitors of aminoglycoside antibiotic resistance enzymes. Boehr DD, Draker KA, Koteva K, Bains M, Hancock RE, Wright GD. Chem Biol. 2003 Feb;10(2):189-96. PMID: 12618191.
The molecular basis of the expansive substrate specificity of the antibiotic resistance enzyme aminoglycoside acetyltransferase-6′-aminoglycoside phosphotransferase-2″. The role of ASP-99 as an active site base important for acetyl transfer. Boehr DD, Jenkins SI, Wright GD. J Biol Chem. 2003 Apr 11;278(15):12873-80. PMID: 12566434.
Analysis of the pi-pi stacking interactions between the aminoglycoside antibiotic kinase APH(3′)-IIIa and its nucleotide ligands. Boehr DD, Farley AR, Wright GD, Cox JR. Chem Biol. 2002 Nov;9(11):1209-17. PMID: 12445771.
Streptogramin antibiotics: mode of action and resistance. Johnston NJ, Mukhtar TA, Wright GD. Curr Drug Targets. 2002 Aug;3(4):335-44. PMID: 12102603.
Assembling the glycopeptide antibiotic scaffold: The biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009. Pootoolal J, Thomas MG, Marshall CG, Neu JM, Hubbard BK, Walsh CT, Wright GD. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8962-7. PMID: 12060705.
Mechanism of aminoglycoside antibiotic kinase APH(3′)-IIIa: role of the nucleotide positioning loop. Thompson PR, Boehr DD, Berghuis AM, Wright GD. Biochemistry. 2002 Jun 4;41(22):7001-7. PMID: 12033933.
StoPK-1, a serine/threonine protein kinase from the glycopeptide antibiotic producer Streptomyces toyocaensis NRRL 15009, affects oxidative stress response. Neu JM, MacMillan SV, Nodwell JR, Wright GD. Mol Microbiol. 2002 Apr;44(2):417-30. PMID: 11972780.
Glycopeptide antibiotic resistance. Pootoolal J, Neu J, Wright GD. Annu Rev Pharmacol Toxicol. 2002;42:381-408. PMID: 11807177.
Active site labeling of the gentamicin resistance enzyme AAC(6′)-APH(2″) by the lipid kinase inhibitor wortmannin. Boehr DD, Lane WS, Wright GD. Chem Biol. 2001 Aug;8(8):791-800. PMID: 11514228.
Vgb from Staphylococcus aureus inactivates streptogramin B antibiotics by an elimination mechanism not hydrolysis. Mukhtar TA, Koteva KP, Hughes DW, Wright GD. Biochemistry. 2001 Jul 31;40(30):8877-86. PMID: 11467949.
Inhibition of sporulation, glycopeptide antibiotic production and resistance in Streptomyces toyocaensis NRRL 15009 by protein kinase inhibitors. Neu JM, Wright GD. FEMS Microbiol Lett. 2001 May 15;199(1):15-20. PMID: 11356561.
Homoserine dehydrogenase from Saccharomyces cerevisiae: kinetic mechanism and stereochemistry of hydride transfer. Jacques SL, Ejim LJ, Wright GD. Biochim Biophys Acta. 2001 Jan 12;1544(1-2):42-54. PMID: 11341915.
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity. Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD. Biochim Biophys Acta. 2001 Jan 12;1544(1-2):28-41. PMID: 11341914.
Molecular mechanism of aminoglycoside antibiotic kinase APH(3′)-IIIa: roles of conserved active site residues. Boehr DD, Thompson PR, Wright GD. J Biol Chem. 2001 Jun 29;276(26):23929-36. PMID: 11279088.
Resisting resistance: new chemical strategies for battling superbugs. Wright GD. Chem Biol. 2000 Jun;7(6):R127-32. PMID: 10873842.
Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases. DeLaBarre B, Thompson PR, Wright GD, Berghuis AM. Nat Struct Biol. 2000 Mar;7(3):238-44. PMID: 10700284.
Crystallization and preliminary X-ray diffraction studies of homoserine dehydrogenase from Saccharomyces cerevisiae. DeLaBarre B, Jacques SL, Pratt CE, Ruth DA, Wright GD, Berghuis AM. Acta Crystallogr D Biol Crystallogr. 1998 May 1;54(Pt 3):413-5. PMID: 9761913.
Glycopeptide antibiotic resistance genes in glycopeptide-producing organisms. Marshall CG, Lessard IA, Park I, Wright GD. Antimicrob Agents Chemother. 1998 Sep;42(9):2215-20. PMID: 9736537.
Spectinomycin kinase from Legionella pneumophila. Characterization of substrate specificity and identification of catalytically important residues. Thompson PR, Hughes DW, Cianciotto NP, Wright GD. J Biol Chem. 1998 Jun 12;273(24):14788-95. PMID: 9614079.
Aminoglycoside antibiotics. Structures, functions, and resistance. Wright GD, Berghuis AM, Mobashery S. Adv Exp Med Biol. 1998;456:27-69. PMID: 10549363.
The COOH terminus of aminoglycoside phosphotransferase (3′)-IIIa is critical for antibiotic recognition and resistance. Thompson PR, Schwartzenhauer J, Hughes DW, Berghuis AM, Wright GD. J Biol Chem. 1999 Oct 22;274(43):30697-706. PMID: 10521458.
Aminoglycoside-modifying enzymes. Wright GD. Curr Opin Microbiol. 1999 Oct;2(5):499-503. PMID: 10508725.
Molecular mechanism of VanHst, an alpha-ketoacid dehydrogenase required for glycopeptide antibiotic resistance from a glycopeptide producing organism. Marshall CG, Zolli M, Wright GD. Biochemistry. 1999 Jun 29;38(26):8485-91. PMID: 10387095.
Crystal structure of an aminoglycoside 6′-N-acetyltransferase: defining the GCN5-related N-acetyltransferase superfamily fold. Wybenga-Groot LE, Draker K, Wright GD, Berghuis AM. Structure. 1999 May;7(5):497-507. PMID: 10378269.