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The Wright Lab

  • Welcome
  • Lab News
  • Team
    • Gerry Wright
    • The Lab
  • Research
    • An Overview
    • Antimicrobial Discovery
    • Antibiotic Resistance
  • Publications
  • Platforms
    • Wright Actinomycete Collection
    • Wright Clinical Collection
    • Antibiotic Resistance Platform
    • The Comprehensive Antibiotic Resistance Database
  • Articles
  • Contact

2015 Publications

Featured | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 1998-2009

 
Featured
Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning.
Dec 23, 2015
Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning.
Dec 23, 2015

Authors: Jan Wildenhain, Michaela Spitzer, Sonam Dolma, Nick Jarvik, Rachel White, Marcia Roy, Emma Griffiths, David S Bellows, Gerard D Wright, Mike Tyers
Reference: Cell Syst. 2015 Dec 23;1(6):383-95. doi: 10.1016/j.cels.2015.12.003. 
PMID: 27136353

Dec 23, 2015
An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens
Nov 17, 2015
An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens
Nov 17, 2015

Authors: Nicole Robbins, Michaela Spitzer, Tennison Yu, Robert P Cerone, Anna K Averette, Yong-Sun Bahn, Joseph Heitman, Donald C Sheppard, Mike Tyers, Gerard D Wright
Reference: Cell Rep. 2015 Nov 17;13(7):1481-92. doi: 10.1016/j.celrep.2015.10.018.
PMID: 26549450

Nov 17, 2015
Biosynthesis of the Fluorinated Natural Product Nucleocidin in Streptomyces calvus Is Dependent on the bldA‐Specified Leu‐tRNAUUA Molecule
Nov 1, 2015
Biosynthesis of the Fluorinated Natural Product Nucleocidin in Streptomyces calvus Is Dependent on the bldA‐Specified Leu‐tRNAUUA Molecule
Nov 1, 2015

Authors: Xi Ming Zhu, Stefanie Hackl, Maulik N Thaker, Lindsay Kalan, Claudia Weber, Dagmar S Urgast, Eva M Krupp, Alyssa Brewer, Stephanie Vanner, Anjuli Szawiola, Grace Yim, Jörg Feldmann, Andreas Bechthold, Gerard D Wright, David L Zechel
Reference: Chembiochem. 2015 Nov;16(17):2498-506. doi: 10.1002/cbic.201500402
PMID: 26374477

Nov 1, 2015
Bioinformatics of antimicrobial resistance in the age of molecular epidemiology
Oct 31, 2015
Bioinformatics of antimicrobial resistance in the age of molecular epidemiology
Oct 31, 2015

Authors: Andrew G McArthur, Gerard D Wright
Reference: Curr Opin Microbiol. 2015 Oct;27:45-50. doi: 10.1016/j.mib.2015.07.004
PMID: 26241506

Oct 31, 2015
Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium
Sep 29, 2015
Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium
Sep 29, 2015

Authors: Luca Freschi, Julie Jeukens, Irena Kukavica-Ibrulj, Brian Boyle, Marie-Josée Dupont, Jérôme Laroche, Stéphane Larose, Halim Maaroufi, Joanne L Fothergill, Matthew Moore, Geoffrey L Winsor, Shawn D Aaron, Jean Barbeau, Scott C Bell, Jane L Burns, Miguel Camara, André Cantin, Steve J Charette, Ken Dewar, Éric Déziel, Keith Grimwood, Robert EW Hancock, Joe J Harrison, Stephan Heeb, Lars Jelsbak, Baofeng Jia, Dervla T Kenna, Timothy J Kidd, Jens Klockgether, Joseph S Lam, Iain L Lamont, Shawn Lewenza, Nick Loman, François Malouin, Jim Manos, Andrew G McArthur, Josie McKeown, Julie Milot, Hardeep Naghra, Dao Nguyen, Sheldon K Pereira, Gabriel G Perron, Jean-Paul Pirnay, Paul B Rainey, Simon Rousseau, Pedro M Santos, Anne Stephenson, Véronique Taylor, Jane F Turton, Nicholas Waglechner, Paul Williams, Sandra W Thrane, Gerard D Wright, Fiona SL Brinkman, Nicholas P Tucker, Burkhard Tümmler, Craig Winstanley, Roger C Levesque
Reference: Front Microbiol. 2015 Sep 29;6:1036. doi: 10.3389/fmicb.2015.01036
PMID: 26483767

Sep 29, 2015
Sep 1, 2015
Minimum information about a biosynthetic gene cluster
Sep 1, 2015

Authors: Marnix H Medema, Renzo Kottmann, Pelin Yilmaz, Matthew Cummings, John B Biggins, Kai Blin, Irene De Bruijn, Yit Heng Chooi, Jan Claesen, R Cameron Coates, Pablo Cruz-Morales, Srikanth Duddela, Stephanie Düsterhus, Daniel J Edwards, David P Fewer, Neha Garg, Christoph Geiger, Juan Pablo Gomez-Escribano, Anja Greule, Michalis Hadjithomas, Anthony S Haines, Eric JN Helfrich, Matthew L Hillwig, Keishi Ishida, Adam C Jones, Carla S Jones, Katrin Jungmann, Carsten Kegler, Hyun Uk Kim, Peter Kötter, Daniel Krug, Joleen Masschelein, Alexey V Melnik, Simone M Mantovani, Emily A Monroe, Marcus Moore, Nathan Moss, Hans-Wilhelm Nützmann, Guohui Pan, Amrita Pati, Daniel Petras, F Jerry Reen, Federico Rosconi, Zhe Rui, Zhenhua Tian, Nicholas J Tobias, Yuta Tsunematsu, Philipp Wiemann, Elizabeth Wyckoff, Xiaohui Yan, Grace Yim, Fengan Yu, Yunchang Xie, Bertrand Aigle, Alexander K Apel, Carl J Balibar, Emily P Balskus, Francisco Barona-Gómez, Andreas Bechthold, Helge B Bode, Rainer Borriss, Sean F Brady, Axel A Brakhage, Patrick Caffrey, Yi-Qiang Cheng, Jon Clardy, Russell J Cox, René De Mot, Stefano Donadio, Mohamed S Donia, Wilfred A van der Donk, Pieter C Dorrestein, Sean Doyle, Arnold JM Driessen, Monika Ehling-Schulz, Karl-Dieter Entian, Michael A Fischbach, Lena Gerwick, William H Gerwick, Harald Gross, Bertolt Gust, Christian Hertweck, Monica Höfte, Susan E Jensen, Jianhua Ju, Leonard Katz, Leonard Kaysser, Jonathan L Klassen, Nancy P Keller, Jan Kormanec, Oscar P Kuipers, Tomohisa Kuzuyama, Nikos C Kyrpides, Hyung-Jin Kwon, Sylvie Lautru, Rob Lavigne, Chia Y Lee, Bai Linquan, Xinyu Liu, Wen Liu, Andriy Luzhetskyy, Taifo Mahmud, Yvonne Mast, Carmen Méndez, Mikko Metsä-Ketelä, Jason Micklefield, Douglas A Mitchell, Bradley S Moore, Leonilde M Moreira, Rolf Müller, Brett A Neilan, Markus Nett, Jens Nielsen, Fergal O'Gara, Hideaki Oikawa, Anne Osbourn, Marcia S Osburne, Bohdan Ostash, Shelley M Payne, Jean-Luc Pernodet, Miroslav Petricek, Jörn Piel, Olivier Ploux, Jos M Raaijmakers, José A Salas, Esther K Schmitt, Barry Scott, Ryan F Seipke, Ben Shen, David H Sherman, Kaarina Sivonen, Michael J Smanski, Margherita Sosio, Evi Stegmann, Roderich D Süssmuth, Kapil Tahlan, Christopher M Thomas, Yi Tang, Andrew W Truman, Muriel Viaud, Jonathan D Walton, Christopher T Walsh, Tilmann Weber, Gilles P Van Wezel, Barrie Wilkinson, Joanne M Willey, Wolfgang Wohlleben, Gerard D Wright, Nadine Ziemert, Changsheng Zhang
Reference: Nat Chem Biol. 2015 Sep;11(9):625-31. doi: 10.1038/nchembio.
PMID: 26284661

Sep 1, 2015
Structural and functional plasticity of antibiotic resistance nucleotidylyltransferases revealed by molecular characterization of lincosamide nucleotidylyltransferases lnu (A) and lnu (D)
Jun 19, 2015
Structural and functional plasticity of antibiotic resistance nucleotidylyltransferases revealed by molecular characterization of lincosamide nucleotidylyltransferases lnu (A) and lnu (D)
Jun 19, 2015

Authors: Peter J Stogios, Elena Evdokimova, Mariya Morar, Kalinka Koteva, Gerard D Wright, Patrice Courvalin, Alexei Savchenko
Reference: J Mol Biol. 2015 Jun 19;427(12):2229-43. doi: 10.1016/j.jmb.2015.04.008
PMID: 25900373

Jun 19, 2015
Zinc Chelation by a Small-Molecule Adjuvant Potentiates Meropenem Activity in Vivo against NDM-1-Producing Klebsiella pneumoniae
May 26, 2015
Zinc Chelation by a Small-Molecule Adjuvant Potentiates Meropenem Activity in Vivo against NDM-1-Producing Klebsiella pneumoniae
May 26, 2015

Authors: Shannon B Falconer, Sarah A Reid-Yu, Andrew M King, Sebastian S Gehrke, Wenliang Wang, James F Britten, Brian K Coombes, Gerard D Wright, Eric D Brown
Reference: ACS Infect Dis. 2015 Nov 13;1(11):533-43. doi: 10.1021/acsinfecdis.5b00033
PMID: 27623408

May 26, 2015
Alternative pathway to a glycopeptide-resistant cell wall in the balhimycin producer Amycolatopsis balhimycina
May 15, 2015
Alternative pathway to a glycopeptide-resistant cell wall in the balhimycin producer Amycolatopsis balhimycina
May 15, 2015

Authors: Hans-Joerg Frasch, Lindsay Kalan, Regina Kilian, Tobias Martin, Gerard D Wright, Evi Stegmann
Reference: ACS Infect Dis. 2015 Jun 12;1(6):243-52. doi: 10.1021/acsinfecdis.5b00011.
PMID: 27622740

May 15, 2015
Vancomycin-variable enterococci can give rise to constitutive resistance during antibiotic therapy
Mar 1, 2015
Vancomycin-variable enterococci can give rise to constitutive resistance during antibiotic therapy
Mar 1, 2015

Authors: Maulik N Thaker, Lindsay Kalan, Nicholas Waglechner, Alireza Eshaghi, Samir N Patel, Susan Poutanen, Barbara Willey, Bryan Coburn, Allison McGeer, Donald E Low, Gerard D Wright
Reference: Antimicrob Agents Chemother. 2015 Mar;59(3):1405-10. doi: 10.1128/AAC.04490-14.
PMID: 25512425

Mar 1, 2015
Structural and molecular basis for resistance to aminoglycoside antibiotics by the adenylyltransferase ANT (2 ″)-Ia
Feb 27, 2015
Structural and molecular basis for resistance to aminoglycoside antibiotics by the adenylyltransferase ANT (2 ″)-Ia
Feb 27, 2015

Authors: Georgina Cox, Peter J Stogios, Alexei Savchenko, Gerard D Wright
Reference: MBio. 2015 Jan 6;6(1). pii: e02180-14. doi: 10.1128/mBio.02180-14.
PMID: 25564464

Feb 27, 2015
Molecular mechanism of avibactam-mediated β-lactamase inhibition
Feb 11, 2015
Molecular mechanism of avibactam-mediated β-lactamase inhibition
Feb 11, 2015

Authors: Dustin T King, Andrew M King, Sarah M Lal, Gerard D Wright, Natalie CJ Strynadka
Reference: ACS Infect Dis. 2015 Apr 10;1(4):175-84. doi: 10.1021/acsinfecdis.5b00007. Epub 2015 Feb 11.
PMID: 27622530

Feb 11, 2015
Jan 22, 2015
Antibiotics: An irresistible newcomer
Jan 22, 2015

Authors: Gerard Wright
Reference: Nature. 2015 Jan 22;517(7535):442-4. doi: 10.1038/nature14193.
PMID: 25561172

Jan 22, 2015
Solving the antibiotic crisis
Jan 15, 2015
Solving the antibiotic crisis
Jan 15, 2015

Authors: Gerard D Wright
Reference: ACS Infect Dis. 2015 Feb 13;1(2):80-4. doi: 10.1021/id500052s.
PMID: 27622298

Jan 15, 2015
Jan 1, 2015
Winners of the 2014 JA Medals for excellence
Jan 1, 2015

Authors: Gerard D Wright, Minoru Yoshida
Reference: J Antibiot (Tokyo). 2015 Jan;68(1):1-2. doi: 10.1038/ja.2014.156.
PMID: 25623837 

Jan 1, 2015

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