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The Wright Lab

  • Welcome
  • Lab News
  • Team
    • Gerry Wright
    • The Lab
  • Research
    • An Overview
    • Antimicrobial Discovery
    • Antibiotic Resistance
  • Publications
  • Platforms
    • Wright Actinomycete Collection
    • Wright Clinical Collection
    • Antibiotic Resistance Platform
    • The Comprehensive Antibiotic Resistance Database
  • Articles
  • Contact

2016 Publications

Featured | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 1998-2009

 
Featured
Evolving medicinal chemistry strategies in antibiotic discovery
Dec 31, 2016
Evolving medicinal chemistry strategies in antibiotic discovery
Dec 31, 2016

Authors: AC Pawlowski, JW Johnson, GD Wright
Reference: Curr Opin Biotechnol. 2016 Apr 23;42:108-117. doi: 10.1016/j.copbio.2016.04.006.
PMID: 27116217

Dec 31, 2016
A diverse intrinsic antibiotic resistome from a cave bacterium
Dec 8, 2016
A diverse intrinsic antibiotic resistome from a cave bacterium
Dec 8, 2016

Authors: Pawlowski AC, Wang W, Koteva K, Barton HA, McArthur AG, Wright GD.
Reference: Nat Commun. 2016 Dec 8;7:13803. doi: 10.1038/ncomms13803.
PMID: 27929110

Dec 8, 2016
Bacterial proteases, untapped antimicrobial drug targets.
Nov 30, 2016
Bacterial proteases, untapped antimicrobial drug targets.
Nov 30, 2016

Authors: E Culp, GD Wright
Reference: Journal of Antibiotics (Tokyo) April; 70(4) 366-377
PMID: 27899793

Nov 30, 2016
A Common Platform for Antibiotic Dereplication and Adjuvant Discovery
Nov 29, 2016
A Common Platform for Antibiotic Dereplication and Adjuvant Discovery
Nov 29, 2016

Authors: Cox G, Sieron A, King AM, De Pascale G, Pawlowski AC, Koteva K, Wright GD.
Reference: Cell Chem Biol. 2016 Nov 29. pii: S2451-9456(16)30434-2. doi: 10.1016/j.chembiol.2016.11.011.
PMID: 28017602

Nov 29, 2016
Systematic chemical-genetic and chemical-chemical interaction datasets for prediction of compound synergism
Nov 22, 2016
Systematic chemical-genetic and chemical-chemical interaction datasets for prediction of compound synergism
Nov 22, 2016

Authors: Wildenhain J, Spitzer M, Dolma S, Jarvik N, White R, Roy M, Griffiths E, Bellows DS, Wright GD, Tyers M.
Reference: Scientific Data 3, Article number: 160095 (2016). doi:10.1038/sdata.2016.95
PMID: 2787484

Nov 22, 2016
Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function
Nov 17, 2016
Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function
Nov 17, 2016

Authors: Robbins N, Spitzer M, Wang W, Waglechner N, Patel DJ, O'Brien JS, Ejim L, Ejim O, Tyers M, Wright GD.
Reference: Cell Chem Biol. 2016 Nov 17;23(11):1383-1394. doi: 10.1016/j.chembiol.2016.08.015.
PMID: 27746129

Nov 17, 2016
Catalytic promiscuity of glycopeptide N-methyltransferases enables bio-orthogonal labelling of biosynthetic intermediates
Nov 1, 2016
Catalytic promiscuity of glycopeptide N-methyltransferases enables bio-orthogonal labelling of biosynthetic intermediates
Nov 1, 2016

Authors: Brieke C, Yim G, Peschke M, Wright GD, Cryle MJ.
Reference: Chem Commun (Camb). 2016 Nov 17;52(94):13679-13682.
PMID: 27812569

Nov 1, 2016
Total Synthesis of Aspergillomarasmine A and Related Compounds: A Sulfamidate Approach Enables Exploration of Structure–Activity Relationships
Sep 1, 2016
Total Synthesis of Aspergillomarasmine A and Related Compounds: A Sulfamidate Approach Enables Exploration of Structure–Activity Relationships
Sep 1, 2016

Authors: SA Albu, K Koteva, AM King, S Al‐Karmi, GD Wright, A Capretta
Reference: Angew Chem Int Ed Engl. 2016 Oct 10;55(42):13259-13262. doi: 10.1002/anie.201606657.
PMID: 27633338

Sep 1, 2016
How To Make a Glycopeptide: A Synthetic Biology Approach To Expand Antibiotic Chemical Diversity
Aug 5, 2016
How To Make a Glycopeptide: A Synthetic Biology Approach To Expand Antibiotic Chemical Diversity
Aug 5, 2016

Authors: G Yim, W Wang, MN Thaker, S Tan, GD Wright
Reference: ACS Infect. Dis., 2016, 2 (9), pp 642–650 DOI: 10.1021/acsinfecdis.6b00105

Aug 5, 2016
Antibiotic Adjuvants: Rescuing Antibiotics from Resistance
Jul 15, 2016
Antibiotic Adjuvants: Rescuing Antibiotics from Resistance
Jul 15, 2016

Authors: GD Wright
Reference: Trends Microbiol. 2016 Jul 15. pii: S0966-842X(16)30072-5. doi: 10.1016/j.tim.2016.06.009. 
PMID: 27430191

Jul 15, 2016
Combinatorial Strategies For Combating Invasive Fungal Infections
Jun 7, 2016
Combinatorial Strategies For Combating Invasive Fungal Infections
Jun 7, 2016

Authors: M Spitzer, N Robbins, GD Wright
Reference: Virulence. 2016 Jun 7:1-17.
PMID: 27268286

Jun 7, 2016
The Prehistory of Antibiotic Resistance
Jun 1, 2016
The Prehistory of Antibiotic Resistance
Jun 1, 2016

Authors: J Perry, N Waglechner, G Wright
Reference: Cold Spring Harbor perspectives in medicine 6 (6), a025197
PMID: 27252395

Jun 1, 2016
Rifampin phosphotransferase is an unusual antibiotic resistance kinase
Apr 22, 2016
Rifampin phosphotransferase is an unusual antibiotic resistance kinase
Apr 22, 2016

Authors: Peter J Stogios, Georgina Cox, Peter Spanogiannopoulos, Monica C Pillon, Nicholas Waglechner, Tatiana Skarina, Kalinka Koteva, Alba Guarné, Alexei Savchenko, Gerard D Wright
Reference: Nat Commun. 2016 Apr 22;7:11343. doi: 10.1038/ncomms11343.
PMID: 27103605

Apr 22, 2016
Beating Superbugs: Innovative Genomics and Policies to Tackle AMR
Apr 1, 2016
Beating Superbugs: Innovative Genomics and Policies to Tackle AMR
Apr 1, 2016

Authors: Rainer Engelhardt, Gerard Wright
Reference: Genome Canada Policy Brief No. 11

Apr 1, 2016
Total Synthesis and Activity of the Metallo‐β‐lactamase Inhibitor Aspergillomarasmine A
Feb 1, 2016
Total Synthesis and Activity of the Metallo‐β‐lactamase Inhibitor Aspergillomarasmine A
Feb 1, 2016

Authors: K Koteva, AM King, A Capretta, GD Wright
Reference: Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2210-2. doi: 10.1002/anie.201510057. 
PMID: 26709849

Feb 1, 2016
Antibacterial drug discovery in the resistance era
Jan 21, 2016
Antibacterial drug discovery in the resistance era
Jan 21, 2016

Authors: ED Brown, GD Wright
Reference: Nature. 2016 Jan 21;529(7586):336-43. doi: 10.1038/nature17042.
PMID: 26791724

Jan 21, 2016
Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins
Jan 14, 2016
Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins
Jan 14, 2016

Authors: Andrew M King, Dustin T King, Shawn French, Eric Brouillette, Abdelhamid Asli, J Andrew N Alexander, Marija Vuckovic, Samarendra N Maiti, Thomas R Parr Jr, Eric D Brown, François Malouin, Natalie CJ Strynadka, Gerard D Wright
Reference: 
ACS Chem Biol. 2016 Apr 15;11(4):864-8. doi: 10.1021/acschembio.5b00944.
PMID: 26731698

Jan 14, 2016
Jan 1, 2016
Antibiotic Resistance themed issue
Jan 1, 2016

Authors: S Garneau-Tsodikova, GD Wright
Reference: MedChemComm 7 (1), 10-10

Jan 1, 2016

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