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The Wright Lab

  • Welcome
  • Lab News
  • Team
    • Gerry Wright
    • The Lab
  • Research
    • An Overview
    • Antimicrobial Discovery
    • Antibiotic Resistance
  • Publications
  • Platforms
    • Wright Actinomycete Collection
    • Wright Clinical Collection
    • Antibiotic Resistance Platform
    • The Comprehensive Antibiotic Resistance Database
  • Articles
  • Contact

2012 Publications

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Featured
December 28, 2012
Opportunities for synthetic biology in antibiotics: expanding glycopeptide chemical diversity
December 28, 2012

Authors: Maulik N Thaker, Gerard D Wright
Reference: ACS Synth Biol. 2015 Mar 20;4(3):195-206. doi: 10.1021/sb300092n.
PMID: 23654249

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December 28, 2012
December 1, 2012
First JA Medal goes to a paper on decalpenic acid
December 1, 2012

Authors: Gerard D Wright, Minoru Yoshida
Reference: J Antibiot (Tokyo). 2012 Dec;65(12):591-2. doi: 10.1038/ja.2012.100.
PMID: 23258426 

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December 1, 2012
Bacterial inactivation of the anticancer drug doxorubicin
October 26, 2012
Bacterial inactivation of the anticancer drug doxorubicin
October 26, 2012

Authors: Erin L Westman, Marc J Canova, Inas J Radhi, Kalinka Koteva, Inga Kireeva, Nicholas Waglechner, Gerard D Wright
Reference: Chem Biol. 2012 Oct 26;19(10):1255-64. doi: 10.1016/j.chembiol.2012.08.011.
PMID: 23102220

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October 26, 2012
October 19, 2012
Inhibition of WTA synthesis blocks the cooperative action of PBPs and sensitizes MRSA to β-lactams
October 19, 2012

Authors: Maya A Farha, Alexander Leung, Edward W Sewell, Michael A D’Elia, Sarah E Allison, Linda Ejim, Pedro M Pereira, Mariana G Pinho, Gerard D Wright, Eric D Brown
Reference: ACS Chem Biol. 2013 Jan 18;8(1):226-33. doi: 10.1021/cb300413m. 
PMID: 23062620 

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October 19, 2012
October 2, 2012
Back to the future: a new ‘old’lead for tuberculosis
October 2, 2012

Authors: Gerard D Wright
Reference: EMBO Mol Med. 2012 Oct;4(10):1029-31. doi: 10.1002/emmm.201201811.
PMID: 22987753

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October 2, 2012
Characterization of a rifampin-inactivating glycosyltransferase from a screen of environmental actinomycetes
October 1, 2012
Characterization of a rifampin-inactivating glycosyltransferase from a screen of environmental actinomycetes
October 1, 2012

Authors: Peter Spanogiannopoulos, Maulik Thaker, Kalinka Koteva, Nicholas Waglechner, Gerard D Wright
Reference: Antimicrob Agents Chemother. 2012 Oct;56(10):5061-9. doi: 10.1128/AAC.01166-12. 
PMID: 22802246 

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October 1, 2012
August 7, 2012
The origins of antibiotic resistance
August 7, 2012

Authors: Gerard D Wright
Reference: Antibiotic Resistance P. 13-30

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August 7, 2012
July 17, 2012
Sulfonation of glycopeptide antibiotics by sulfotransferase StaL depends on conformational flexibility of aglycone scaffold
July 17, 2012

Authors: Rong Shi, Christine Munger, Lindsay Kalan, Traian Sulea, Gerard D Wright, Miroslaw Cygler
Reference: Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11824-9. doi: 10.1073/pnas.1205377109. 
PMID: 22753479

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July 17, 2012
June 22, 2012
A forward chemical screen identifies antibiotic adjuvants in Escherichia coli
June 22, 2012

Authors: Patricia L Taylor, Laura Rossi, Gianfranco De Pascale, Gerard D Wrigh
Reference: ACS Chem Biol. 2012 Sep 21;7(9):1547-55.
PMID: 22698393

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June 22, 2012
June 15, 2012
Diversity of integron-and culture-associated antibiotic resistance genes in freshwater floc
June 15, 2012

Authors: Christopher N Drudge, Amy VC Elliott, Janina M Plach, Linda J Ejim, Gerard D Wright, Ian G Droppo, Lesley A Warren
Reference: Appl Environ Microbiol. 2012 Jun;78(12):4367-72. doi: 10.1128/AEM.00405-12
PMID: 22467502

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June 15, 2012
April 30, 2012
Antibiotic resistance is ancient: implications for drug discovery
April 30, 2012

Authors: Gerard D Wright, Hendrik Poinar
Reference: Trends Microbiol. 2012 Apr;20(4):157-9. doi: 10.1016/j.tim.2012.01.002. 
PMID: 22284896 

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April 30, 2012
Antibiotic resistance is prevalent in an isolated cave microbiome
April 11, 2012
Antibiotic resistance is prevalent in an isolated cave microbiome
April 11, 2012

Authors: Kirandeep Bhullar, Nicholas Waglechner, Andrew Pawlowski, Kalinka Koteva, Eric D Banks, Michael D Johnston, Hazel A Barton, Gerard D Wright
Reference: PLoS One. 2012;7(4):e34953. doi: 10.1371/journal.pone.0034953.
PMID: 22509370 

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April 11, 2012
March 15, 2012
Determining the mode of action of bioactive compounds
March 15, 2012

Authors: Marisa A Azad, Gerard D Wright
Reference: Bioorg Med Chem. 2012 Mar 15;20(6):1929-39. doi: 10.1016/j.bmc.2011.10.088. 
PMID: 22300885 

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March 15, 2012
March 1, 2012
Small-molecule modulators of Listeria monocytogenes biofilm development
March 1, 2012

Authors: Uyen T Nguyen, Iwona B Wenderska, Matthew A Chong, Kalinka Koteva, Gerard D Wright, Lori L Burrows
Reference: Appl Environ Microbiol. 2012 Mar;78(5):1454-65. doi: 10.1128/AEM.07227-11. 
PMID: 22194285 

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March 1, 2012
February 10, 2012
Mechanism and diversity of the erythromycin esterase family of enzymes
February 10, 2012

Authors: Mariya Morar, Kate Pengelly, Kalinka Koteva, Gerard D Wright
Reference: Biochemistry. 2012 Feb 28;51(8):1740-51. doi: 10.1021/bi201790u.
PMID: 22303981 

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February 10, 2012
Inactivation of the lipopeptide antibiotic daptomycin by hydrolytic mechanisms
February 1, 2012
Inactivation of the lipopeptide antibiotic daptomycin by hydrolytic mechanisms
February 1, 2012

Authors: Vanessa M D'Costa, Tariq A Mukhtar, Tejal Patel, Kalinka Koteva, Nicholas Waglechner, Donald W Hughes, Gerard D Wright, Gianfranco De Pascale
Reference: Antimicrob Agents Chemother. 2012 Feb;56(2):757-64. doi: 10.1128/AAC.05441-11.
PMID: 22083474 

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February 1, 2012
January 27, 2012
Antibiotics: a new hope
January 27, 2012

Authors: Gerard D Wright
Reference: Chem Biol. 2012 Jan 27;19(1):3-10. doi: 10.1016/j.chembiol.2011.10.019.
PMID: 22284349

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January 27, 2012
January 24, 2012
Antibiotic resistome: A framework linking the clinic and the environment
January 24, 2012

Authors: Gerard D Wright
Reference: Antimicrobial Resistance in the Environment

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January 24, 2012
Biosynthetic gene cluster and antimicrobial activity of the elfamycin antibiotic factumycin
January 1, 2012
Biosynthetic gene cluster and antimicrobial activity of the elfamycin antibiotic factumycin
January 1, 2012

Authors: MN Thaker, M García, K Koteva, N Waglechner, D Sorensen, R Medina, GD Wright
Reference: Med. Chem. Commun., 2012,3, 1020-1026 DOI: 10.1039/C2MD20038D

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January 1, 2012

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