Authors: Rong Shi, Christine Munger, Lindsay Kalan, Traian Sulea, Gerard D Wright, Miroslaw Cygler
Reference: Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11824-9. doi: 10.1073/pnas.1205377109.
PMID: 22753479
A forward chemical screen identifies antibiotic adjuvants in Escherichia coli →
Authors: Patricia L Taylor, Laura Rossi, Gianfranco De Pascale, Gerard D Wrigh
Reference: ACS Chem Biol. 2012 Sep 21;7(9):1547-55.
PMID: 22698393
Diversity of integron-and culture-associated antibiotic resistance genes in freshwater floc →
Authors: Christopher N Drudge, Amy VC Elliott, Janina M Plach, Linda J Ejim, Gerard D Wright, Ian G Droppo, Lesley A Warren
Reference: Appl Environ Microbiol. 2012 Jun;78(12):4367-72. doi: 10.1128/AEM.00405-12
PMID: 22467502
Antibiotic resistance is ancient: implications for drug discovery →
Authors: Gerard D Wright, Hendrik Poinar
Reference: Trends Microbiol. 2012 Apr;20(4):157-9. doi: 10.1016/j.tim.2012.01.002.
PMID: 22284896
Antibiotic resistance is prevalent in an isolated cave microbiome →
Authors: Kirandeep Bhullar, Nicholas Waglechner, Andrew Pawlowski, Kalinka Koteva, Eric D Banks, Michael D Johnston, Hazel A Barton, Gerard D Wright
Reference: PLoS One. 2012;7(4):e34953. doi: 10.1371/journal.pone.0034953.
PMID: 22509370
Determining the mode of action of bioactive compounds →
Authors: Marisa A Azad, Gerard D Wright
Reference: Bioorg Med Chem. 2012 Mar 15;20(6):1929-39. doi: 10.1016/j.bmc.2011.10.088.
PMID: 22300885
Small-molecule modulators of Listeria monocytogenes biofilm development →
Authors: Uyen T Nguyen, Iwona B Wenderska, Matthew A Chong, Kalinka Koteva, Gerard D Wright, Lori L Burrows
Reference: Appl Environ Microbiol. 2012 Mar;78(5):1454-65. doi: 10.1128/AEM.07227-11.
PMID: 22194285
Mechanism and diversity of the erythromycin esterase family of enzymes →
Authors: Mariya Morar, Kate Pengelly, Kalinka Koteva, Gerard D Wright
Reference: Biochemistry. 2012 Feb 28;51(8):1740-51. doi: 10.1021/bi201790u.
PMID: 22303981
Inactivation of the lipopeptide antibiotic daptomycin by hydrolytic mechanisms →
Authors: Vanessa M D'Costa, Tariq A Mukhtar, Tejal Patel, Kalinka Koteva, Nicholas Waglechner, Donald W Hughes, Gerard D Wright, Gianfranco De Pascale
Reference: Antimicrob Agents Chemother. 2012 Feb;56(2):757-64. doi: 10.1128/AAC.05441-11.
PMID: 22083474
Antibiotics: a new hope →
Authors: Gerard D Wright
Reference: Chem Biol. 2012 Jan 27;19(1):3-10. doi: 10.1016/j.chembiol.2011.10.019.
PMID: 22284349
Antibiotic resistome: A framework linking the clinic and the environment →
Authors: Gerard D Wright
Reference: Antimicrobial Resistance in the Environment
Biosynthetic gene cluster and antimicrobial activity of the elfamycin antibiotic factumycin →
Authors: MN Thaker, M García, K Koteva, N Waglechner, D Sorensen, R Medina, GD Wright
Reference: Med. Chem. Commun., 2012,3, 1020-1026 DOI: 10.1039/C2MD20038D
A small molecule discrimination map of the antibiotic resistance kinome →
Authors: Tushar Shakya, Peter J Stogios, Nicholas Waglechner, Elena Evdokimova, Linda Ejim, Jan E Blanchard, Andrew G McArthur, Alexei Savchenko, Gerard D Wright
Reference: Chem Biol. 2011 Dec 23;18(12):1591-601. doi: 10.1016/j.chembiol.2011.10.018.
PMID: 22195561
Palmitoyl‐DL‐carnitine is a multitarget inhibitor of Pseudomonas aeruginosa biofilm development →
Authors: Iwona B Wenderska, Matthew Chong, James McNulty, Gerard D Wright, Lori L Burrows
Reference: Chembiochem. 2011 Dec 16;12(18):2759-66. doi: 10.1002/cbic.201100500
PMID: 22045628
Microwave-assisted synthesis of N1-and C3-substituted pyrazolo [3, 4-d] pyrimidine libraries →
Authors: Nick Todorovic, Emelia Awuah, Tushar Shakya, Gerard D Wright, Alfredo Capretta
Reference: Tetrahedron Letters Volume 52, Issue 44, 2 November 2011, Pages 5761–5763
Antibiotic resistance is ancient →
Authors: Vanessa M D’Costa, Christine E King, Lindsay Kalan, Mariya Morar, Wilson WL Sung, Carsten Schwarz, Duane Froese, Grant Zazula, Fabrice Calmels, Regis Debruyne, G Brian Golding, Hendrik N Poinar, Gerard D Wright
Reference: Nature. 2011 Aug 31;477(7365):457-61. doi: 10.1038/nature10388.
PMID: 21881561
An ecological perspective of microbial secondary metabolism →
Authors: Jonathan O’Brien, Gerard D Wright
Reference: Curr Opin Biotechnol. 2011 Aug;22(4):552-8. doi: 10.1016/j.copbio.2011.03.010.
PMID: 21498065
β-Lactone natural products and derivatives inactivate homoserine transacetylase, a target for antimicrobial agents →
Authors: Gianfranco De Pascale, Ishac Nazi, Paul HM Harrison, Gerard D Wright
Reference: J Antibiot (Tokyo). 2011 Jul;64(7):483-7. doi: 10.1038/ja.2011.37
PMID: 21522158
Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase →
Authors: G Volkers, GJ Palm, MS Weiss, GD Wright, W Hinrichs
Reference: FEBS Lett. 2011 Apr 6;585(7):1061-6. doi: 10.1016/j.febslet.2011.03.012.
PMID: 21402075
Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy →
Authors: Linda Ejim, Maya A Farha, Shannon B Falconer, Jan Wildenhain, Brian K Coombes, Mike Tyers, Eric D Brown, Gerard D Wright
Reference: Nat Chem Biol. 2011 Jun;7(6):348-50. doi: 10.1038/nchembio.559.
PMID: 21516114