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The Wright Lab

  • Welcome
  • Lab News
  • Team
    • Gerry Wright
    • The Lab
  • Research
    • An Overview
    • Antimicrobial Discovery
    • Antibiotic Resistance
  • Publications
  • Platforms
    • Wright Actinomycete Collection
    • Wright Clinical Collection
    • Antibiotic Resistance Platform
    • The Comprehensive Antibiotic Resistance Database
  • Articles
  • Contact

The Antibiotic Resistome: Origins, Diversity, and Future Prospects →

Authors: Erin L Westman, Gerard D Wright
Reference: Handbook of Molecular Microbial Ecology II: Metagenomics in Different Habitats - Pages 165-174

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tags: 2011
Wednesday 06.01.11
Posted by Wright Lab
 

Identification and characterization of new inhibitors of fungal homoserine kinase →

Authors: Gianfranco De Pascale, Emma J Griffiths, Tushar Shakya, Ishac Nazi, Gerard D Wright
Reference: Chembiochem. 2011 May 16;12(8):1179-82. doi: 10.1002/cbic.201100121.
PMID: 21538764

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tags: 2011
Monday 05.16.11
Posted by Wright Lab
 

Antibiotic adjuvants: multicomponent anti-infective strategies →

Authors: Lindsay Kalan, Gerard D Wright
Reference: Expert Rev Mol Med. 2011 Feb 23;13:e5. doi: 10.1017/S1462399410001766.
PMID: 21342612 

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tags: 2011
Sunday 05.01.11
Posted by Wright Lab
 

Molecular mechanisms of antibiotic resistance →

Authors: Gerard D Wright
Reference: Chem Commun (Camb). 2011 Apr 14;47(14):4055-61. doi: 10.1039/c0cc05111j.
PMID: 21286630 

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tags: 2011
Thursday 04.14.11
Posted by Wright Lab
 

Receptor domains of two-component signal transduction systems →

Authors: Julie Perry, Kalinka Koteva, Gerard Wright
Reference: Mol Biosyst. 2011 May;7(5):1388-98. doi: 10.1039/c0mb00329h.
PMID: 21347487

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tags: 2011, Kalinka Koteva
Thursday 02.24.11
Posted by Wright Lab
 

Structure and function of APH (4)-Ia, a hygromycin B resistance enzyme →

Authors: Peter J Stogios, Tushar Shakya, Elena Evdokimova, Alexei Savchenko, Gerard D Wright
Reference: J Biol Chem. 2011 Jan 21;286(3):1966-75. doi: 10.1074/jbc.M110.194266. 
PMID: 21084294 

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tags: 2011
Friday 01.21.11
Posted by Wright Lab
 

Cross‐species discovery of syncretic drug combinations that potentiate the antifungal fluconazole →

Authors: Michaela Spitzer, Emma Griffiths, Kim M Blakely, Jan Wildenhain, Linda Ejim, Laura Rossi, Gianfranco De Pascale, Jasna Curak, Eric Brown, Mike Tyers, Gerard D Wright
Reference: Mol Syst Biol. 2011 Jun 21;7:499. doi: 10.1038/msb.2011.31.
PMID: 21694716

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tags: 2011
Saturday 01.01.11
Posted by Wright Lab
 

Redox Mechanisms and Reactive Oxygen Species in Antibiotic Action and Resistance →

Authors: Inas J Radhi, Gerard D Wright
Reference: Bacterial Stress Responses, Second Edition, P. 461-471

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tags: 2011
Saturday 01.01.11
Posted by Wright Lab
 

The genomic enzymology of antibiotic resistance →

Authors: Mariya Morar, Gerard D Wright
Reference: Annu Rev Genet. 2010;44:25-51. doi: 10.1146/annurev-genet-102209-163517.
PMID: 20822442

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tags: 2010
Wednesday 12.01.10
Posted by Wright Lab
 

Antibiotic resistance in the environment: a link to the clinic? →

Authors: Gerard D Wright
Reference: Curr Opin Microbiol. 2010 Oct;13(5):589-94. doi: 10.1016/j.mib.2010.08.005.
PMID: 20850375

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tags: 2010
Sunday 10.31.10
Posted by Wright Lab
 

Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: a model for the ClpX/ClpA-bound state of ClpP →

Authors: Dominic Him Shun Li, Yu Seon Chung, Melanie Gloyd, Ebenezer Joseph, Rodolfo Ghirlando, Gerard D Wright, Yi-Qiang Cheng, Michael R Maurizi, Alba Guarné, Joaquin Ortega
Reference: Chem Biol. 2010 Sep 24;17(9):959-69. doi: 10.1016/j.chembiol.2010.07.008.
PMID: 20851345 

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tags: 2010
Friday 09.24.10
Posted by Wright Lab
 

Q&A: Antibiotic resistance: where does it come from and what can we do about it? →

Authors: Gerard D Wright
Reference: BMC Biol. 2010 Sep 20;8:123. doi: 10.1186/1741-7007-8-123.
PMID: 20887638 

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tags: 2010
Monday 09.20.10
Posted by Wright Lab
 

The antibiotic resistome →

Authors: Gerard D Wright
Reference: Expert Opin Drug Discov. 2010 Aug;5(8):779-88. doi: 10.1517/17460441.2010.497535. 
PMID: 22827799

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tags: 2010
Sunday 08.01.10
Posted by Wright Lab
 

Antibiotic resistance by enzyme inactivation: from mechanisms to solutions →

Authors: Gianfranco De Pascale, Gerard D Wright
Reference: Chembiochem. 2010 Jul 5;11(10):1325-34. doi: 10.1002/cbic.201000067.
PMID: 20564281 

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tags: 2010
Monday 07.05.10
Posted by Wright Lab
 

A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor →

Authors: Kalinka Koteva, Hee-Jeon Hong, Xiao Dong Wang, Ishac Nazi, Donald Hughes, Mike J Naldrett, Mark J Buttner, Gerard D Wright
Reference: Nat Chem Biol. 2010 May;6(5):327-9. doi: 10.1038/nchembio.350.
PMID: 20383152 

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tags: 2010, Kalinka Koteva
Saturday 05.01.10
Posted by Wright Lab
 

Nucleotide selectivity of antibiotic kinases →

Authors: Tushar Shakya, Gerard D Wright
Reference: Antimicrob Agents Chemother. 2010 May;54(5):1909-13. doi: 10.1128/AAC.01570-09
PMID: 20231391

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tags: 2010
Saturday 05.01.10
Posted by Wright Lab
 

Crystallization and preliminary X-ray crystallographic analysis of the tetracycline-degrading monooxygenase TetX2 from Bacteroides thetaiotaomicron →

Authors: Gesa Volkers, Linda Schuldt, Gottfried J Palm, Gerard D Wright, Winfried Hinrichs
Reference: Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 May 1;66(Pt 5):611-4. doi: 10.1107/S174430911001225X.
PMID: 20445272 

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tags: 2010
Saturday 05.01.10
Posted by Wright Lab
 

Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1 →

Authors: Nancy L McKenzie, Maulik Thaker, Kalinka Koteva, Donald W Hughes, Gerard D Wright, Justin R Nodwell
Reference: J Antibiot (Tokyo). 2010 Apr;63(4):177-82. doi: 10.1038/ja.2010.13. 
PMID: 20224601 

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tags: 2010, Kalinka Koteva
Thursday 04.01.10
Posted by Wright Lab
 

Antibiotics: inactive but not inert →

Authors: Gerard D Wright
Reference: Nat Chem Biol. 2010 Feb;6(2):85-6. doi: 10.1038/nchembio.299.
PMID: 20081820

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tags: 2010
Tuesday 02.02.10
Posted by Wright Lab
 

The tetracycline resistome →

Authors: Maulik Thaker, Peter Spanogiannopoulos, Gerard D Wright
Reference: Cell Mol Life Sci. 2010 Feb;67(3):419-31. doi: 10.1007/s00018-009-0172-6. 
PMID: 19862477

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tags: 2010
Monday 02.01.10
Posted by Wright Lab
 
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