Authors: Chen, X., Koteva, K., Chou, S., Guitor, A., Pallant, D., Lee, Y., Sychantha, D., French, S., Hackenberger, D., Robbins, N., Cook, M.A., Brown, E.D., MacNeil, L.T., Cowen, L.E., & Wright, G.D.
Reference: Nature Communications
DOI: 10.1038/s41467-025-62630-z
PMID: 40781075
Identification and characterization of the siderochelin biosynthetic gene cluster via coculture →
Authors: Schaenzer, A. J., Wang, W., Hackenberger, D., Wright, G.D.
Reference: ASM mBio.
DOI: 10.1128/mbio.01871-24
PMID: 39189743
The Janus Effect: The Biochemical Logic of Antibiotic Resistance →
Authors: Wright, G.D.
Reference: Published as part of Biochemistry special issue “A Tribute to Christopher T. Walsh”
DOI: 10.1021/acs.biochem.4c00585
PMID: 39772429
PMID:40140562
CARPDM: cost-effective antibiotic resistome profiling of metagenomic samples using targeted enrichment →
Authors: Hackenberger, D., Imtiaz, H., Raphenya, A.R., Alcock, B.P., Poinar, H.N., Wright, G.D., McArthur, A.G.
Reference: ASM Applied and Environmental Microbiology
DOI: 10.1128/aem.01876-24
PMID: 40019273
PMID:40140562
A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome →
Authors: Jangra, M., Travin, D.Y., Aleksandrova, E.V., Kaur, M., Darwish, L., Koteva, K., Klepacki, D., Wang, W., Tiffany, M., Sokaribo, A., Coombes, B.K., Vázquez-Laslop, N., Polikanov, Y.S., Mankin A.S., & Wright, G.D.
Reference: Nature
DOI: 10.1038/s41586-025-08723-7
PMID: 40140562
Revisiting the potential of natural products in antimycobacterial therapy: advances in drug discovery and semisynthetic solutions →
Authors: George, M., & Wright, G.D.
Reference: Current Opinion in Microbiology
DOI: 10.1016/j.mib.2024.102576
PMID: 39742555
CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database →
Authors: Brian P Alcock, William Huynh, Romeo Chalil, Keaton W Smith, Amogelang R Raphenya, Mateusz A Wlodarski, Arman Edalatmand, Aaron Petkau, Sohaib A Syed, Kara K Tsang, Sheridan J C Baker, Mugdha Dave, Madeline C McCarthy, Karyn M Mukiri, Jalees A Nasir, Bahar Golbon, Hamna Imtiaz, Xingjian Jiang, Komal Kaur, Megan Kwong, Zi Cheng Liang, Keyu C Niu, Prabakar Shan, Jasmine Y J Yang, Kristen L Gray, Gemma R Hoad, Baofeng Jia, Timsy Bhando, Lindsey A Carfrae, Maya A Farha, Shawn French, Rodion Gordzevich, Kenneth Rachwalski, Megan M Tu, Emily Bordeleau, Damion Dooley, Emma Griffiths, Haley L Zubyk, Eric D Brown, Finlay Maguire, Robert G Beiko, William W L Hsiao, Fiona S L Brinkman, Gary Van Domselaar, Andrew G McArthur.
Reference: Nucleic Acids Research
DOI: 10.1093/nar/gkac920
PMID: 36263822
Minimal Impact on the Resistome of Children in Botswana After Azithromycin Treatment for Acute Severe Diarrheal Disease →
Authors: Guitor A.K, Katyukhina A, Mokomane M, Lechiile K, Goldfarb D.M, Wright G.D, McArthur A.G, Pernica J.M.
Reference: The Journal of Infectious Diseases
DOI: 10.1093/infdis/jiae049
PMID: 39052715
Antibiotic resistance: A key microbial survival mechanism that threatens public health →
Authors: Abbas A*, Barkhouse A*, Hackenberger D, Wright G.D.
Reference: Cell Host & Microbe
DOI: 10.1016/j.chom.2024.05.015
PMID: 38870900
Targeting bacterial nickel transport with aspergillomarasmine A suppresses virulence-associated Ni-dependent enzymes →
Authors: Sychantha D, Chen X, Koteva K, Prehna G, Wright G.D.
Reference: Nature Communications
DOI: 10.1038/s41467-024-48232-1
PMID: 38740750
Lessons from assembling a microbial natural product and pre-fractionated extract library in an academic laboratory →
Authors: Cook M.A, Pallant D, Ejim L, Sutherland A.D, Wang X, Johnson J.W, McCusker S, Chen X, George A, Chou S, Koteva K, Wang W, Hobson C, Hackenberger D, Waglechner N, Ejim O, Campbell T, Medina R, MacNeil L.T, Wright G.D.
Reference: Journal of Industrial Microbiology and Biotechnology
DOI: 10.1093/jimb/kuad042
PMID: 38052426
Synthetic Biology Facilitates Semisynthetic Development of Type V Glycopeptide Antibiotics Targeting Vancomycin-Resistant Enterococcus →
Authors: Kalinka Koteva, Min Xu, Wenliang Wang, Aline A. Fiebig-Comyn, Michael A. Cook, Brian K. Coombes, and Gerard D. Wright
Reference: The Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.3c00633
PMID: 37315221
Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance →
Authors: Bordeleau E, Stogios PJ, Evdokimova E, Koteva K, Savchenko A, Wright GD.
Reference: Nature Chemical Biology
DOI: 10.1038/s41589-023-01483-3
PMID: 37973888
Angucyclinones rescue PhLOPSA antibiotic activity by inhibiting Cfr-dependent antibiotic resistance →
Authors: Schaenzer AJ, Hernandez AR, Tsai K, Hobson C, Fujimori DG, Wright GD.
Reference: ASM mBio.
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PMID: 38014974
Capturing the antibiotic resistome of preterm infants reveals new benefits of probiotic supplementation. →
Authors: Guitor AK, Yousuf EI, Raphenya AR, Hutton EK, Morrison KM, McArthur AG, Wright GD, Stearns JC.
Reference: Microbiome.
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PMID: PMC9414150
The past, present, and future of antibiotics →
Authors: Cook MA, Wright GD.
Reference: Sci Transl Med.
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PMID: 35947678
HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics →
Authors: Surette MD, Waglechner N, Koteva K, Wright GD.
Reference: Mol Cell.
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PMID: 35907401
Phylogeny-Informed Synthetic Biology Reveals Unprecedented Structural Novelty in Type V Glycopeptide Antibiotics →
Authors: Min Xu, Wenliang Wang, Nicholas Waglechner, Elizabeth J. Culp, Allison K. Guitor, and Gerard D. Wright.
Reference: ACS Central Science
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PMID:
Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family →
Authors: Stogios PJ, Bordeleau E, Xu Z, Skarina T, Evdokimova E, Chou S, Diorio-Toth L, D'Souza AW, Patel S, Dantas G, Wright GD, Savchenko A.
Reference: Commun Biol.
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PMID: 35338238.
ClpP inhibitors are produced by a widespread family of bacterial gene clusters →
Authors: Culp EJ, Sychantha D, Hobson C, Pawlowski AC, Prehna G, Wright GD.
Reference: Nat Microbiol.
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PMID: 35246663.