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Capturing the antibiotic resistome of preterm infants reveals new benefits of probiotic supplementation. →
Authors: Guitor AK, Yousuf EI, Raphenya AR, Hutton EK, Morrison KM, McArthur AG, Wright GD, Stearns JC.
Reference: Microbiome.
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The past, present, and future of antibiotics →
Authors: Cook MA, Wright GD.
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PMID: 35947678
HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics →
Authors: Surette MD, Waglechner N, Koteva K, Wright GD.
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PMID: 35907401
Phylogeny-Informed Synthetic Biology Reveals Unprecedented Structural Novelty in Type V Glycopeptide Antibiotics →
Authors: Min Xu, Wenliang Wang, Nicholas Waglechner, Elizabeth J. Culp, Allison K. Guitor, and Gerard D. Wright.
Reference: ACS Central Science
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PMID:
Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family →
Authors: Stogios PJ, Bordeleau E, Xu Z, Skarina T, Evdokimova E, Chou S, Diorio-Toth L, D'Souza AW, Patel S, Dantas G, Wright GD, Savchenko A.
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PMID: 35338238.
ClpP inhibitors are produced by a widespread family of bacterial gene clusters →
Authors: Culp EJ, Sychantha D, Hobson C, Pawlowski AC, Prehna G, Wright GD.
Reference: Nat Microbiol.
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PMID: 35246663.
Three-Dimensional Structure and Optimization of the Metallo-β-Lactamase Inhibitor Aspergillomarasmine A →
Authors: Koteva K, Sychantha D, Rotondo CM, Hobson C, Britten JF, Wright GD.
Reference: ACS Omega.
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PMID: 35155911.
Prospects for Antibacterial Discovery and Development →
Authors: Privalsky TM, Soohoo AM, Wang J, Walsh CT, Wright GD, Gordon EM, Gray NS, Khosla C.
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Glycopeptide antibiotic discovery in the genomic era →
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Demonstration of the role of cell wall homeostasis in Staphylococcus aureus growth and the action of bactericidal antibiotics →
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A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity →
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CrpP Is Not a Fluoroquinolone-Inactivating Enzyme →
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Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2 →
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PMID: PMC8319579.
Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics →
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PMID: 33979648.
The Enzymes of the Rifamycin Antibiotic Resistome →
Authors: Surette MD, Spanogiannopoulos P, Wright GD.
Reference: Accounts of Chemical Research
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PMID: 33877820.
A Screen of Natural Product Extracts Identifies Moenomycin as a Potent Antigonococcal Agent →
Authors: Yarlagadda V, Rao VN, Kaur M, Guitor AK, Wright GD.
Reference: ACS Infect Dis.
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PMID: 33826296.
Ancient Antibiotics, Ancient Resistance →
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PMID: 33734062.
The Antibiotic Resistome: A Guide for the Discovery of Natural Products as Antimicrobial Agents →
Authors: Hobson C, Chan AN, Wright GD.
Reference: Chem Rev.
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PMID: 33606500.
ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin →
Authors: Bordeleau E, Stogios PJ, Evdokimova E, Koteva K, Savchenko A, Wright GD.
Reference: mBio
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PMID: 33563840