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The Wright Lab

  • Welcome
  • Lab News
  • Team
    • Gerry Wright
    • The Lab
  • Research
    • An Overview
    • Antimicrobial Discovery
    • Antibiotic Resistance
  • Publications
  • Platforms
    • Wright Actinomycete Collection
    • Wright Clinical Collection
    • Antibiotic Resistance Platform
    • The Comprehensive Antibiotic Resistance Database
  • Articles
  • Contact
 

First Last, Degree

Position: Ph.D Candidate/ M.Sc. Candidate/ Undergraduate Thesis Student

About:

Li Europan lingues es membres del sam familie. Lor separat existentie es un myth. Por scientie, musica, sport etc, litot Europa usa li sam vocabular. Li lingues differe solmen in li grammatica, li pronunciation e li plu commun vocabules. Omnicos directe al desirabilite de un nov lingua franca: On refusa continuar payar custosi traductores. At solmen va esser necessi far uniform grammatica, pronunciation e plu sommun paroles. Ma quande lingues coalesce, li grammatica del resultant

 
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Research Interests:

Li Europan lingues es membres del sam familie. Lor separat existentie es un myth. Por scientie, musica, sport etc, litot Europa usa li sam vocabular. Li lingues differe solmen in li grammatica, li pronunciation e li plu commun vocabules. Omnicos directe al desirabilite de un nov lingua franca: On refusa continuar payar custosi traductores. At solmen va esser necessi far uniform grammatica, pronunciation e plu sommun paroles. Ma quande lingues coalesce, li grammatica del resultant

Publications:

Featured
April 20, 2026
An Acetyltransferase Conferring Self-Resistance of the Producer to Lasso Peptide Antibiotic Lariocidin
April 20, 2026

Authors: Jangra, M., Travin, D.Y., Kaur, M., Hackenberger, D., Koteva, K., Polikanov, Y.S., Wright, G.D.
Reference: ACS Infect Dis.
DOI:  10.1021/acsinfecdis.5c00885
PMID: 41532636

April 20, 2026
April 20, 2026
Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi
April 20, 2026

Authors: Chen, X., Duan, H.D., Hoy, M.J., Koteva, K., Spitzer, M., Guitor, A.K., Puumala, E., Fiebig, A.A., Hu, G., Yiu, B., Chou, S., Bian, Z., Choi, Y., Ya Guo, A.B., Wang, W., Sun, S., Robbins, N., Averette, A.F., Cook, M.A., Truant, R., MacNeil, L.T., Brown, E.D., Kronstad, J.W., Coombes, B.K., Cowen, L.E., Heitman, J., Li, H., Wright, G.D.
Reference: Cell
DOI:  10.1016/j.cell.2025.11.036
PMID: 41478284

April 20, 2026
September 8, 2025
Coniontins, lipopetaibiotics active against Candida auris identified from a microbial natural product fractionation library
September 8, 2025

Authors: Chen, X., Koteva, K., Chou, S., Guitor, A., Pallant, D., Lee, Y., Sychantha, D., French, S., Hackenberger, D., Robbins, N., Cook, M.A., Brown, E.D., MacNeil, L.T., Cowen, L.E., & Wright, G.D.
Reference: Nature Communications
DOI:  10.1038/s41467-025-62630-z
PMID: 40781075

September 8, 2025
June 11, 2025
Identification and characterization of the siderochelin biosynthetic gene cluster via coculture
June 11, 2025
June 11, 2025
May 8, 2025
The Janus Effect: The Biochemical Logic of Antibiotic Resistance
May 8, 2025

Authors: Wright, G.D.
Reference: Published as part of Biochemistry special issue “A Tribute to Christopher T. Walsh”
DOI:  10.1021/acs.biochem.4c00585
PMID: 39772429
PMID:40140562

May 8, 2025
May 8, 2025
CARPDM: cost-effective antibiotic resistome profiling of metagenomic samples using targeted enrichment
May 8, 2025

Authors: Hackenberger, D., Imtiaz, H., Raphenya, A.R., Alcock, B.P., Poinar, H.N., Wright, G.D., McArthur, A.G.
Reference: ASM Applied and Environmental Microbiology
DOI:  10.1128/aem.01876-24
PMID: 40019273
PMID:40140562

May 8, 2025
April 25, 2025
A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome
April 25, 2025

Authors: Jangra, M., Travin, D.Y., Aleksandrova, E.V., Kaur, M., Darwish, L., Koteva, K., Klepacki, D., Wang, W., Tiffany, M., Sokaribo, A., Coombes, B.K., Vázquez-Laslop, N., Polikanov, Y.S., Mankin A.S., & Wright, G.D.
Reference: Nature
DOI:  10.1038/s41586-025-08723-7
PMID: 40140562

April 25, 2025
January 6, 2025
Revisiting the potential of natural products in antimycobacterial therapy: advances in drug discovery and semisynthetic solutions
January 6, 2025

Authors: George, M., & Wright, G.D.
Reference: Current Opinion in Microbiology
DOI:  10.1016/j.mib.2024.102576
PMID: 39742555

January 6, 2025
December 11, 2024
CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database
December 11, 2024

Authors: Brian P Alcock, William Huynh, Romeo Chalil, Keaton W Smith, Amogelang R Raphenya, Mateusz A Wlodarski, Arman Edalatmand, Aaron Petkau, Sohaib A Syed, Kara K Tsang, Sheridan J C Baker, Mugdha Dave, Madeline C McCarthy, Karyn M Mukiri, Jalees A Nasir, Bahar Golbon, Hamna Imtiaz, Xingjian Jiang, Komal Kaur, Megan Kwong, Zi Cheng Liang, Keyu C Niu, Prabakar Shan, Jasmine Y J Yang, Kristen L Gray, Gemma R Hoad, Baofeng Jia, Timsy Bhando, Lindsey A Carfrae, Maya A Farha, Shawn French, Rodion Gordzevich, Kenneth Rachwalski, Megan M Tu, Emily Bordeleau, Damion Dooley, Emma Griffiths, Haley L Zubyk, Eric D Brown, Finlay Maguire, Robert G Beiko, William W L Hsiao, Fiona S L Brinkman, Gary Van Domselaar, Andrew G McArthur.
Reference: Nucleic Acids Research
DOI: 10.1093/nar/gkac920
PMID: 36263822

December 11, 2024
August 6, 2024
Minimal Impact on the Resistome of Children in Botswana After Azithromycin Treatment for Acute Severe Diarrheal Disease
August 6, 2024

Authors: Guitor A.K, Katyukhina A, Mokomane M, Lechiile K, Goldfarb D.M, Wright G.D, McArthur A.G, Pernica J.M.
Reference: The Journal of Infectious Diseases
DOI:  10.1093/infdis/jiae049
PMID: 39052715

August 6, 2024
July 10, 2024
Antibiotic resistance: A key microbial survival mechanism that threatens public health
July 10, 2024

Authors: Abbas A*, Barkhouse A*, Hackenberger D, Wright G.D.
Reference: Cell Host & Microbe 
DOI:  10.1016/j.chom.2024.05.015
PMID: 38870900

July 10, 2024
June 10, 2024
Targeting bacterial nickel transport with aspergillomarasmine A suppresses virulence-associated Ni-dependent enzymes
June 10, 2024

Authors: Sychantha D, Chen X, Koteva K, Prehna G, Wright G.D.
Reference: Nature Communications 
DOI:  10.1038/s41467-024-48232-1
PMID: 38740750

June 10, 2024
June 10, 2024
Lessons from assembling a microbial natural product and pre-fractionated extract library in an academic laboratory
June 10, 2024

Authors: Cook M.A, Pallant D, Ejim L, Sutherland A.D, Wang X, Johnson J.W, McCusker S, Chen X, George A, Chou S, Koteva K, Wang W, Hobson C, Hackenberger D, Waglechner N, Ejim O, Campbell T, Medina R, MacNeil L.T, Wright G.D.
Reference:  Journal of Industrial Microbiology and Biotechnology
DOI:  10.1093/jimb/kuad042
PMID: 38052426

June 10, 2024
June 10, 2024
Synthetic Biology Facilitates Semisynthetic Development of Type V Glycopeptide Antibiotics Targeting Vancomycin-Resistant Enterococcus
June 10, 2024

Authors: Kalinka Koteva, Min Xu, Wenliang Wang, Aline A. Fiebig-Comyn, Michael A. Cook,  Brian K. Coombes, and Gerard D. Wright
Reference:  The Journal of Medicinal Chemistry
DOI:  10.1021/acs.jmedchem.3c00633
PMID: 37315221

June 10, 2024
June 10, 2024
Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance
June 10, 2024

Authors: Bordeleau E, Stogios PJ, Evdokimova E, Koteva K, Savchenko A, Wright GD.
Reference: Nature Chemical Biology
DOI: 10.1038/s41589-023-01483-3
PMID: 37973888

June 10, 2024
March 8, 2024
Angucyclinones rescue PhLOPSA antibiotic activity by inhibiting Cfr-dependent antibiotic resistance
March 8, 2024

Authors: Schaenzer AJ, Hernandez AR, Tsai K, Hobson C, Fujimori DG, Wright GD.
Reference: ASM mBio.
DOI: 10.1128/mbio.01791-23
PMID: 38014974

March 8, 2024
August 26, 2022
Capturing the antibiotic resistome of preterm infants reveals new benefits of probiotic supplementation.
August 26, 2022

Authors: Guitor AK, Yousuf EI, Raphenya AR, Hutton EK, Morrison KM, McArthur AG, Wright GD, Stearns JC.
Reference: Microbiome.
DOI: 10.1186/s40168-022-01327-7.
PMID: PMC9414150

August 26, 2022
August 22, 2022
The past, present, and future of antibiotics
August 22, 2022

Authors: Cook MA, Wright GD.
Reference: Sci Transl Med.
DOI: 10.1126/scitranslmed.abo7793.
PMID: 35947678

August 22, 2022
July 30, 2022
HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics
July 30, 2022

Authors: Surette MD, Waglechner N, Koteva K, Wright GD.
Reference: Mol Cell.
DOI: 10.1016/j.molcel.2022.06.019.
PMID: 35907401

July 30, 2022
April 27, 2022
Phylogeny-Informed Synthetic Biology Reveals Unprecedented Structural Novelty in Type V Glycopeptide Antibiotics
April 27, 2022

Authors: Min Xu, Wenliang Wang, Nicholas Waglechner, Elizabeth J. Culp, Allison K. Guitor, and Gerard D. Wright.
Reference: ACS Central Science
DOI: 10.1021/acscentsci.1c01389.
PMID:

April 27, 2022
March 25, 2022
Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family
March 25, 2022

Authors: Stogios PJ, Bordeleau E, Xu Z, Skarina T, Evdokimova E, Chou S, Diorio-Toth L, D'Souza AW, Patel S, Dantas G, Wright GD, Savchenko A.
Reference: Commun Biol.
DOI: 10.1038/s42003-022-03219-w.
PMID: 35338238.

March 25, 2022
March 4, 2022
ClpP inhibitors are produced by a widespread family of bacterial gene clusters
March 4, 2022

Authors: Culp EJ, Sychantha D, Hobson C, Pawlowski AC, Prehna G, Wright GD.
Reference: Nat Microbiol.
DOI: 10.1038/s41564-022-01073-4.
PMID: 35246663.

March 4, 2022
January 26, 2022
Three-Dimensional Structure and Optimization of the Metallo-β-Lactamase Inhibitor Aspergillomarasmine A
January 26, 2022

Authors: Koteva K, Sychantha D, Rotondo CM, Hobson C, Britten JF, Wright GD.
Reference: ACS Omega.
DOI: 10.1021/acsomega.1c05757.
PMID: 35155911.

January 26, 2022
December 22, 2021
Prospects for Antibacterial Discovery and Development
December 22, 2021

Authors: Privalsky TM, Soohoo AM, Wang J, Walsh CT, Wright GD, Gordon EM, Gray NS, Khosla C.
Reference: J Am Chem Soc.
DOI: 10.1021/jacs.1c10200.
PMID: 34860516.

December 22, 2021
December 21, 2021
Glycopeptide antibiotic discovery in the genomic era
December 21, 2021

Authors: Xu M, Wang W, Wright GD.
Reference: Methods Enzymol.
DOI: 10.1016/bs.mie.2021.11.009. .
PMID: 35379441.

December 21, 2021
November 2, 2021
Demonstration of the role of cell wall homeostasis in Staphylococcus aureus growth and the action of bactericidal antibiotics
November 2, 2021

Authors: Salamaga B, Kong L, Pasquina-Lemonche L, Lafage L, von Und Zur Muhlen M, Gibson JF, Grybchuk D, Tooke AK, Panchal V, Culp EJ, Tatham E, O'Kane ME, Catley TE, Renshaw SA, Wright GD, Plevka P, Bullough PA, Han A, Hobbs JK, Foster SJ.
Reference: Proc Natl Acad Sci U S A
DOI: 10.1073/pnas.2106022118.
PMID: 34716264.

November 2, 2021
October 23, 2021
A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity
October 23, 2021

Authors: Alder A, Struck NS, Xu M, Johnson JW, Wang W, Pallant D, Cook MA, Rambow J, Lemcke S, Gilberger TW, Wright GD.
Reference: Cell Chem Biol.
DOI: 10.1016/j.chembiol.2021.10.005.
PMID: 34710358.

October 23, 2021
July 16, 2021
CrpP Is Not a Fluoroquinolone-Inactivating Enzyme
July 16, 2021

Authors: Zubyk HL, Wright GD.
Reference: Antimicrob Agents Chemother.
DOI: 10.1128/AAC.00773-21.
PMID: 34001507.

July 16, 2021
June 25, 2021
Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2
June 25, 2021

Authors: Sychantha D, Rotondo CM, Tehrani KHME, Martin NI, Wright GD.
Reference: J Biol Chem.
DOI: 10.1016/j.jbc.2021.100918.
PMID: PMC8319579.

June 25, 2021
May 7, 2021
Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics
May 7, 2021

Authors: Benoit YD, Mitchell RR, Wang W, Orlando L, Boyd AL, Tanasijevic B, Aslostovar L, Shapovalova Z, Doyle M, Bergin CJ, Vojnits K, Casado FL, Di Lu J, Porras DP, García-Rodriguez JL, Russell J, Zouggar A, Masibag AN, Caba C, Koteva K, Kinthada LK, Patel JS, Andres SN, Magolan J, Collins TJ, Wright GD, Bhatia M.
Reference: Cell Chem Biol.
DOI: doi: 10.1016/j.chembiol.2021.04.014.
PMID: 33979648.

May 7, 2021
 
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