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    • Gerry Wright
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The Wright Lab

  • Welcome
  • Lab News
  • Team
    • Gerry Wright
    • The Lab
  • Research
    • An Overview
    • Antimicrobial Discovery
    • Antibiotic Resistance
  • Publications
  • Platforms
    • Wright Actinomycete Collection
    • Wright Clinical Collection
    • Antibiotic Resistance Platform
    • The Comprehensive Antibiotic Resistance Database
  • Articles
  • Contact
 

First Last, Degree

Position: Ph.D Candidate/ M.Sc. Candidate/ Undergraduate Thesis Student

About:

Li Europan lingues es membres del sam familie. Lor separat existentie es un myth. Por scientie, musica, sport etc, litot Europa usa li sam vocabular. Li lingues differe solmen in li grammatica, li pronunciation e li plu commun vocabules. Omnicos directe al desirabilite de un nov lingua franca: On refusa continuar payar custosi traductores. At solmen va esser necessi far uniform grammatica, pronunciation e plu sommun paroles. Ma quande lingues coalesce, li grammatica del resultant

 
Email
 

Research Interests:

Li Europan lingues es membres del sam familie. Lor separat existentie es un myth. Por scientie, musica, sport etc, litot Europa usa li sam vocabular. Li lingues differe solmen in li grammatica, li pronunciation e li plu commun vocabules. Omnicos directe al desirabilite de un nov lingua franca: On refusa continuar payar custosi traductores. At solmen va esser necessi far uniform grammatica, pronunciation e plu sommun paroles. Ma quande lingues coalesce, li grammatica del resultant

Publications:

Featured
Jun 11, 2025
Identification and characterization of the siderochelin biosynthetic gene cluster via coculture
Jun 11, 2025
Jun 11, 2025
May 8, 2025
The Janus Effect: The Biochemical Logic of Antibiotic Resistance
May 8, 2025

Authors: Wright, G.D.
Reference: Published as part of Biochemistry special issue “A Tribute to Christopher T. Walsh”
DOI:  10.1021/acs.biochem.4c00585
PMID: 39772429
PMID:40140562

May 8, 2025
May 8, 2025
CARPDM: cost-effective antibiotic resistome profiling of metagenomic samples using targeted enrichment
May 8, 2025

Authors: Hackenberger, D., Imtiaz, H., Raphenya, A.R., Alcock, B.P., Poinar, H.N., Wright, G.D., McArthur, A.G.
Reference: ASM Applied and Environmental Microbiology
DOI:  10.1128/aem.01876-24
PMID: 40019273
PMID:40140562

May 8, 2025
Apr 25, 2025
A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome
Apr 25, 2025

Authors: Jangra, M., Travin, D.Y., Aleksandrova, E.V., Kaur, M., Darwish, L., Koteva, K., Klepacki, D., Wang, W., Tiffany, M., Sokaribo, A., Coombes, B.K., Vázquez-Laslop, N., Polikanov, Y.S., Mankin A.S., & Wright, G.D.
Reference: Nature
DOI:  10.1038/s41586-025-08723-7
PMID: 40140562

Apr 25, 2025
Jan 6, 2025
Revisiting the potential of natural products in antimycobacterial therapy: advances in drug discovery and semisynthetic solutions
Jan 6, 2025

Authors: George, M., & Wright, G.D.
Reference: Current Opinion in Microbiology
DOI:  10.1016/j.mib.2024.102576
PMID: 39742555

Jan 6, 2025
Dec 11, 2024
CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database
Dec 11, 2024

Authors: Brian P Alcock, William Huynh, Romeo Chalil, Keaton W Smith, Amogelang R Raphenya, Mateusz A Wlodarski, Arman Edalatmand, Aaron Petkau, Sohaib A Syed, Kara K Tsang, Sheridan J C Baker, Mugdha Dave, Madeline C McCarthy, Karyn M Mukiri, Jalees A Nasir, Bahar Golbon, Hamna Imtiaz, Xingjian Jiang, Komal Kaur, Megan Kwong, Zi Cheng Liang, Keyu C Niu, Prabakar Shan, Jasmine Y J Yang, Kristen L Gray, Gemma R Hoad, Baofeng Jia, Timsy Bhando, Lindsey A Carfrae, Maya A Farha, Shawn French, Rodion Gordzevich, Kenneth Rachwalski, Megan M Tu, Emily Bordeleau, Damion Dooley, Emma Griffiths, Haley L Zubyk, Eric D Brown, Finlay Maguire, Robert G Beiko, William W L Hsiao, Fiona S L Brinkman, Gary Van Domselaar, Andrew G McArthur.
Reference: Nucleic Acids Research
DOI: 10.1093/nar/gkac920
PMID: 36263822

Dec 11, 2024
Aug 6, 2024
Minimal Impact on the Resistome of Children in Botswana After Azithromycin Treatment for Acute Severe Diarrheal Disease
Aug 6, 2024

Authors: Guitor A.K, Katyukhina A, Mokomane M, Lechiile K, Goldfarb D.M, Wright G.D, McArthur A.G, Pernica J.M.
Reference: The Journal of Infectious Diseases
DOI:  10.1093/infdis/jiae049
PMID: 39052715

Aug 6, 2024
Jul 10, 2024
Antibiotic resistance: A key microbial survival mechanism that threatens public health
Jul 10, 2024

Authors: Abbas A*, Barkhouse A*, Hackenberger D, Wright G.D.
Reference: Cell Host & Microbe 
DOI:  10.1016/j.chom.2024.05.015
PMID: 38870900

Jul 10, 2024
Jun 10, 2024
Targeting bacterial nickel transport with aspergillomarasmine A suppresses virulence-associated Ni-dependent enzymes
Jun 10, 2024

Authors: Sychantha D, Chen X, Koteva K, Prehna G, Wright G.D.
Reference: Nature Communications 
DOI:  10.1038/s41467-024-48232-1
PMID: 38740750

Jun 10, 2024
Jun 10, 2024
Lessons from assembling a microbial natural product and pre-fractionated extract library in an academic laboratory
Jun 10, 2024

Authors: Cook M.A, Pallant D, Ejim L, Sutherland A.D, Wang X, Johnson J.W, McCusker S, Chen X, George A, Chou S, Koteva K, Wang W, Hobson C, Hackenberger D, Waglechner N, Ejim O, Campbell T, Medina R, MacNeil L.T, Wright G.D.
Reference:  Journal of Industrial Microbiology and Biotechnology
DOI:  10.1093/jimb/kuad042
PMID: 38052426

Jun 10, 2024
Jun 10, 2024
Synthetic Biology Facilitates Semisynthetic Development of Type V Glycopeptide Antibiotics Targeting Vancomycin-Resistant Enterococcus
Jun 10, 2024

Authors: Kalinka Koteva, Min Xu, Wenliang Wang, Aline A. Fiebig-Comyn, Michael A. Cook,  Brian K. Coombes, and Gerard D. Wright
Reference:  The Journal of Medicinal Chemistry
DOI:  10.1021/acs.jmedchem.3c00633
PMID: 37315221

Jun 10, 2024
Jun 10, 2024
Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance
Jun 10, 2024

Authors: Bordeleau E, Stogios PJ, Evdokimova E, Koteva K, Savchenko A, Wright GD.
Reference: Nature Chemical Biology
DOI: 10.1038/s41589-023-01483-3
PMID: 37973888

Jun 10, 2024
Mar 8, 2024
Angucyclinones rescue PhLOPSA antibiotic activity by inhibiting Cfr-dependent antibiotic resistance
Mar 8, 2024

Authors: Schaenzer AJ, Hernandez AR, Tsai K, Hobson C, Fujimori DG, Wright GD.
Reference: ASM mBio.
DOI: 10.1128/mbio.01791-23
PMID: 38014974

Mar 8, 2024
Aug 26, 2022
Capturing the antibiotic resistome of preterm infants reveals new benefits of probiotic supplementation.
Aug 26, 2022

Authors: Guitor AK, Yousuf EI, Raphenya AR, Hutton EK, Morrison KM, McArthur AG, Wright GD, Stearns JC.
Reference: Microbiome.
DOI: 10.1186/s40168-022-01327-7.
PMID: PMC9414150

Aug 26, 2022
Aug 22, 2022
The past, present, and future of antibiotics
Aug 22, 2022

Authors: Cook MA, Wright GD.
Reference: Sci Transl Med.
DOI: 10.1126/scitranslmed.abo7793.
PMID: 35947678

Aug 22, 2022
Jul 30, 2022
HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics
Jul 30, 2022

Authors: Surette MD, Waglechner N, Koteva K, Wright GD.
Reference: Mol Cell.
DOI: 10.1016/j.molcel.2022.06.019.
PMID: 35907401

Jul 30, 2022
Apr 27, 2022
Phylogeny-Informed Synthetic Biology Reveals Unprecedented Structural Novelty in Type V Glycopeptide Antibiotics
Apr 27, 2022

Authors: Min Xu, Wenliang Wang, Nicholas Waglechner, Elizabeth J. Culp, Allison K. Guitor, and Gerard D. Wright.
Reference: ACS Central Science
DOI: 10.1021/acscentsci.1c01389.
PMID:

Apr 27, 2022
Mar 25, 2022
Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family
Mar 25, 2022

Authors: Stogios PJ, Bordeleau E, Xu Z, Skarina T, Evdokimova E, Chou S, Diorio-Toth L, D'Souza AW, Patel S, Dantas G, Wright GD, Savchenko A.
Reference: Commun Biol.
DOI: 10.1038/s42003-022-03219-w.
PMID: 35338238.

Mar 25, 2022
Mar 4, 2022
ClpP inhibitors are produced by a widespread family of bacterial gene clusters
Mar 4, 2022

Authors: Culp EJ, Sychantha D, Hobson C, Pawlowski AC, Prehna G, Wright GD.
Reference: Nat Microbiol.
DOI: 10.1038/s41564-022-01073-4.
PMID: 35246663.

Mar 4, 2022
Jan 26, 2022
Three-Dimensional Structure and Optimization of the Metallo-β-Lactamase Inhibitor Aspergillomarasmine A
Jan 26, 2022

Authors: Koteva K, Sychantha D, Rotondo CM, Hobson C, Britten JF, Wright GD.
Reference: ACS Omega.
DOI: 10.1021/acsomega.1c05757.
PMID: 35155911.

Jan 26, 2022
Dec 22, 2021
Prospects for Antibacterial Discovery and Development
Dec 22, 2021

Authors: Privalsky TM, Soohoo AM, Wang J, Walsh CT, Wright GD, Gordon EM, Gray NS, Khosla C.
Reference: J Am Chem Soc.
DOI: 10.1021/jacs.1c10200.
PMID: 34860516.

Dec 22, 2021
Dec 21, 2021
Glycopeptide antibiotic discovery in the genomic era
Dec 21, 2021

Authors: Xu M, Wang W, Wright GD.
Reference: Methods Enzymol.
DOI: 10.1016/bs.mie.2021.11.009. .
PMID: 35379441.

Dec 21, 2021
Nov 2, 2021
Demonstration of the role of cell wall homeostasis in Staphylococcus aureus growth and the action of bactericidal antibiotics
Nov 2, 2021

Authors: Salamaga B, Kong L, Pasquina-Lemonche L, Lafage L, von Und Zur Muhlen M, Gibson JF, Grybchuk D, Tooke AK, Panchal V, Culp EJ, Tatham E, O'Kane ME, Catley TE, Renshaw SA, Wright GD, Plevka P, Bullough PA, Han A, Hobbs JK, Foster SJ.
Reference: Proc Natl Acad Sci U S A
DOI: 10.1073/pnas.2106022118.
PMID: 34716264.

Nov 2, 2021
Oct 23, 2021
A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity
Oct 23, 2021

Authors: Alder A, Struck NS, Xu M, Johnson JW, Wang W, Pallant D, Cook MA, Rambow J, Lemcke S, Gilberger TW, Wright GD.
Reference: Cell Chem Biol.
DOI: 10.1016/j.chembiol.2021.10.005.
PMID: 34710358.

Oct 23, 2021
Jul 16, 2021
CrpP Is Not a Fluoroquinolone-Inactivating Enzyme
Jul 16, 2021

Authors: Zubyk HL, Wright GD.
Reference: Antimicrob Agents Chemother.
DOI: 10.1128/AAC.00773-21.
PMID: 34001507.

Jul 16, 2021
Jun 25, 2021
Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2
Jun 25, 2021

Authors: Sychantha D, Rotondo CM, Tehrani KHME, Martin NI, Wright GD.
Reference: J Biol Chem.
DOI: 10.1016/j.jbc.2021.100918.
PMID: PMC8319579.

Jun 25, 2021
May 7, 2021
Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics
May 7, 2021

Authors: Benoit YD, Mitchell RR, Wang W, Orlando L, Boyd AL, Tanasijevic B, Aslostovar L, Shapovalova Z, Doyle M, Bergin CJ, Vojnits K, Casado FL, Di Lu J, Porras DP, García-Rodriguez JL, Russell J, Zouggar A, Masibag AN, Caba C, Koteva K, Kinthada LK, Patel JS, Andres SN, Magolan J, Collins TJ, Wright GD, Bhatia M.
Reference: Cell Chem Biol.
DOI: doi: 10.1016/j.chembiol.2021.04.014.
PMID: 33979648.

May 7, 2021
May 4, 2021
The Enzymes of the Rifamycin Antibiotic Resistome
May 4, 2021

Authors: Surette MD, Spanogiannopoulos P, Wright GD.
Reference: Accounts of Chemical Research
DOI: 10.1021/acs.accounts.1c00048
PMID: 33877820.

May 4, 2021
Apr 7, 2021
A Screen of Natural Product Extracts Identifies Moenomycin as a Potent Antigonococcal Agent
Apr 7, 2021

Authors: Yarlagadda V, Rao VN, Kaur M, Guitor AK, Wright GD.
Reference: ACS Infect Dis.
DOI: doi: 10.1021/acsinfecdis.1c00040.
PMID: 33826296.

Apr 7, 2021
Mar 9, 2021
Ancient Antibiotics, Ancient Resistance
Mar 9, 2021

Authors: Waglechner N, Culp EJ, Wright GD.
Reference: EcoSal Plus.
DOI: doi: 10.1128/ecosalplus.ESP-0027-2020.
PMID: 33734062.

Mar 9, 2021
 
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