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The Wright Lab

  • Welcome
  • Lab News
  • Team
    • Gerry Wright
    • The Lab
  • Research
    • An Overview
    • Antimicrobial Discovery
    • Antibiotic Resistance
  • Publications
  • Platforms
    • Wright Actinomycete Collection
    • Wright Clinical Collection
    • Antibiotic Resistance Platform
    • The Comprehensive Antibiotic Resistance Database
  • Articles
  • Contact
 
Michael_Cook

cookm6@mcmaster.ca

Michael Cook, Ph.D.

Position: Research Coordinator

About:

I joined the Wright lab in September 2016.  In my previous work in the laboratory of Dr. Michael Tyers, I investigated the genetic determinants of cell size control in various species (S. cerevisiae, C. albicans, M. musculus, and H. sapiens) and the interplay between size genetics and the environment. 

 
Email
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Research Interests:

One of the difficulties of work with natural products is the difficulty in obtaining material from often rare or difficult to culture species which may or may not express the required genes under the conditions of investigation. My work entails expressing biosynthetic genes and pathways in the genetically tractable yeast Saccharomyces cerevisiae and assaying the activity of their products.

Publications:

Featured
The past, present, and future of antibiotics
Aug 22, 2022
The past, present, and future of antibiotics
Aug 22, 2022

Authors: Cook MA, Wright GD.
Reference: Sci Transl Med.
DOI: 10.1126/scitranslmed.abo7793.
PMID: 35947678

Aug 22, 2022
A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity
Oct 23, 2021
A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity
Oct 23, 2021

Authors: Alder A, Struck NS, Xu M, Johnson JW, Wang W, Pallant D, Cook MA, Rambow J, Lemcke S, Gilberger TW, Wright GD.
Reference: Cell Chem Biol.
DOI: 10.1016/j.chembiol.2021.10.005.
PMID: 34710358.

Oct 23, 2021
Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development
Feb 24, 2020
Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development
Feb 24, 2020

Authors: Jacques S, van der Sloot AM, Huard CC, Coulombe-Huntington J, Tsao S, Tollis S, Bertomeu T, Culp EJ, Pallant D, Cook MA, Bonneil E, Thibault P, Wright GD and Tyers M.
Reference: Genetics
DOI: 10.1534/genetics.119.302851
PMID: 32094149

Feb 24, 2020
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