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The Wright Lab

  • Welcome
  • Lab News
  • Team
    • Gerry Wright
    • The Lab
  • Research
    • An Overview
    • Antimicrobial Discovery
    • Antibiotic Resistance
  • Publications
  • Platforms
    • Wright Actinomycete Collection
    • Wright Clinical Collection
    • Antibiotic Resistance Platform
    • The Comprehensive Antibiotic Resistance Database
  • Articles
  • Contact
 
Kalinka.png

kotevak@mcmaster.ca

Kalinka Koteva, Ph.D.

Position: Research Associate

About:

I have joined Gerry's lab in July 2000 as a post doc. In 2002 I became Research associate. The passion for science and people in the lab made me stay all this years. I have acquired the immense amount of knowledge and I truly  think it is the best place for science.

 
Email
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Research Interests:

Currently involved in natural product synthesis and modifications for structure activity relationship studies. We are also working on expanding chemical diversity by making new compounds with improved biological properties on their own or in combinations with other antibiotics. Other areas are identification and structural elucidation of natural products derived from our microbial extracts collection by high resolution mass spectrometry (HRMS/MS) and nuclear magnetic resonance (NMR) techniques. My passion is synthesis of activity based probes for studying antibiotic activity and resistance.

Publications:

Featured
HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics
July 30, 2022
HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics
July 30, 2022

Authors: Surette MD, Waglechner N, Koteva K, Wright GD.
Reference: Mol Cell.
DOI: 10.1016/j.molcel.2022.06.019.
PMID: 35907401

July 30, 2022
Three-Dimensional Structure and Optimization of the Metallo-β-Lactamase Inhibitor Aspergillomarasmine A
January 26, 2022
Three-Dimensional Structure and Optimization of the Metallo-β-Lactamase Inhibitor Aspergillomarasmine A
January 26, 2022

Authors: Koteva K, Sychantha D, Rotondo CM, Hobson C, Britten JF, Wright GD.
Reference: ACS Omega.
DOI: 10.1021/acsomega.1c05757.
PMID: 35155911.

January 26, 2022
Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics
May 7, 2021
Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics
May 7, 2021

Authors: Benoit YD, Mitchell RR, Wang W, Orlando L, Boyd AL, Tanasijevic B, Aslostovar L, Shapovalova Z, Doyle M, Bergin CJ, Vojnits K, Casado FL, Di Lu J, Porras DP, García-Rodriguez JL, Russell J, Zouggar A, Masibag AN, Caba C, Koteva K, Kinthada LK, Patel JS, Andres SN, Magolan J, Collins TJ, Wright GD, Bhatia M.
Reference: Cell Chem Biol.
DOI: doi: 10.1016/j.chembiol.2021.04.014.
PMID: 33979648.

May 7, 2021
ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin
February 9, 2021
ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin
February 9, 2021

Authors: Bordeleau E, Stogios PJ, Evdokimova E, Koteva K, Savchenko A, Wright GD.
Reference: mBio
DOI: 10.1128/mBio.02705-20
PMID: 33563840

February 9, 2021
Resistance-Guided Discovery of Elfamycin Antibiotic Producers with Antigonococcal Activity
November 7, 2020
Resistance-Guided Discovery of Elfamycin Antibiotic Producers with Antigonococcal Activity
November 7, 2020

Authors: Yarlagadda V, Medina R, Johnson TA, Koteva KP, Cox G, Thaker MN, Wright GD.
Reference: ACS Infect Dis.
DOI: 10.1021/acsinfecdis.0c00467
PMID: 33164482

November 7, 2020
Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling
February 12, 2020
Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling
February 12, 2020

Authors: Culp EJ, Waglecher N, Wang W, Fiebig-Comyn AA, Hsu Y, Koteva K, Sychantha D, Coombes BK, Van Nieuwenhze MS, Brun YV and Wright GD
Reference: Nature
DOI: 10.1038/s41586-020-1990-9
PMID: 32051588

February 12, 2020
Suppression of β-Lactam Resistance by Aspergillomarasmine A Is Influenced by both the Metallo-β-Lactamase Target and the Antibiotic Partner
January 14, 2020
Suppression of β-Lactam Resistance by Aspergillomarasmine A Is Influenced by both the Metallo-β-Lactamase Target and the Antibiotic Partner
January 14, 2020

Authors: Rotondo CM, Sychantha D, Koteva K and Wright GD
Reference: Antimicrob Agents Chemother.
DOI: 10.1128/AAC.01386-19
PMID: 31932375

January 14, 2020
Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes
June 4, 2018
Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes
June 4, 2018

Authors: Cox G, Ejim L, Stogios PJ, Koteva K, Bordeleau E, Sieron AO, Savchenko A, Serio AW, Krause KM, Wright GD
Reference: ACS Infectious Diseases 2018
DOI: 10.1021/acsinfecdis.8b00001
PMID: 29634241

June 4, 2018
Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action.
February 1, 2018
Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action.
February 1, 2018

Authors: Koteva K, Cox G, Kelso JK, Surette MD, Zubyk HL, Ejim L, Stogios P, Savchenko A, Sørensen, Wright GD
Reference: Cell Chemical Biology 2018 Jan 26. pii: S2451-9456(18)30031-X
DOI: 10.1016/j.chembiol.2018.01.009.
PMID: 29398560

February 1, 2018
The evolution of substrate discrimination in macrolide antibiotic resistance enzymes.
January 9, 2018
The evolution of substrate discrimination in macrolide antibiotic resistance enzymes.
January 9, 2018

Authors: Pawlowski AC, Stogios PJ, Koteva K, Skarina T, Evdokimova E, Savchenko A, Wright GD
Reference: Nature Communications 2018 ;9(1):112
DOI: 10.1038/s41467-017-02680-0.
PMID: 29317655

January 9, 2018
The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies.
December 19, 2017
The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies.
December 19, 2017

Authors: Pawlowski AC, Westman EL, Koteva K, Waglechner N, Wright GD
Reference: ISME vol 12, 885–897
DOI: 10.1038/s41396-017-0017-5
PMID: 29259290

December 19, 2017
A diverse intrinsic antibiotic resistome from a cave bacterium
December 8, 2016
A diverse intrinsic antibiotic resistome from a cave bacterium
December 8, 2016

Authors: Pawlowski AC, Wang W, Koteva K, Barton HA, McArthur AG, Wright GD.
Reference: Nat Commun. 2016 Dec 8;7:13803. doi: 10.1038/ncomms13803.
PMID: 27929110

December 8, 2016
A Common Platform for Antibiotic Dereplication and Adjuvant Discovery
November 29, 2016
A Common Platform for Antibiotic Dereplication and Adjuvant Discovery
November 29, 2016

Authors: Cox G, Sieron A, King AM, De Pascale G, Pawlowski AC, Koteva K, Wright GD.
Reference: Cell Chem Biol. 2016 Nov 29. pii: S2451-9456(16)30434-2. doi: 10.1016/j.chembiol.2016.11.011.
PMID: 28017602

November 29, 2016
Total Synthesis of Aspergillomarasmine A and Related Compounds: A Sulfamidate Approach Enables Exploration of Structure–Activity Relationships
September 1, 2016
Total Synthesis of Aspergillomarasmine A and Related Compounds: A Sulfamidate Approach Enables Exploration of Structure–Activity Relationships
September 1, 2016

Authors: SA Albu, K Koteva, AM King, S Al‐Karmi, GD Wright, A Capretta
Reference: Angew Chem Int Ed Engl. 2016 Oct 10;55(42):13259-13262. doi: 10.1002/anie.201606657.
PMID: 27633338

September 1, 2016
Rifampin phosphotransferase is an unusual antibiotic resistance kinase
April 22, 2016
Rifampin phosphotransferase is an unusual antibiotic resistance kinase
April 22, 2016

Authors: Peter J Stogios, Georgina Cox, Peter Spanogiannopoulos, Monica C Pillon, Nicholas Waglechner, Tatiana Skarina, Kalinka Koteva, Alba Guarné, Alexei Savchenko, Gerard D Wright
Reference: Nat Commun. 2016 Apr 22;7:11343. doi: 10.1038/ncomms11343.
PMID: 27103605

April 22, 2016
Total Synthesis and Activity of the Metallo‐β‐lactamase Inhibitor Aspergillomarasmine A
February 1, 2016
Total Synthesis and Activity of the Metallo‐β‐lactamase Inhibitor Aspergillomarasmine A
February 1, 2016

Authors: K Koteva, AM King, A Capretta, GD Wright
Reference: Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2210-2. doi: 10.1002/anie.201510057. 
PMID: 26709849

February 1, 2016
Structural and functional plasticity of antibiotic resistance nucleotidylyltransferases revealed by molecular characterization of lincosamide nucleotidylyltransferases lnu (A) and lnu (D)
June 19, 2015
Structural and functional plasticity of antibiotic resistance nucleotidylyltransferases revealed by molecular characterization of lincosamide nucleotidylyltransferases lnu (A) and lnu (D)
June 19, 2015

Authors: Peter J Stogios, Elena Evdokimova, Mariya Morar, Kalinka Koteva, Gerard D Wright, Patrice Courvalin, Alexei Savchenko
Reference: J Mol Biol. 2015 Jun 19;427(12):2229-43. doi: 10.1016/j.jmb.2015.04.008
PMID: 25900373

June 19, 2015
Harnessing the Synthetic Capabilities of Glycopeptide Antibiotic Tailoring Enzymes: Characterization of the UK‐68,597 Biosynthetic Cluster
November 24, 2014
Harnessing the Synthetic Capabilities of Glycopeptide Antibiotic Tailoring Enzymes: Characterization of the UK‐68,597 Biosynthetic Cluster
November 24, 2014

Authors: Grace Yim, Lindsay Kalan, Kalinka Koteva, Maulik N Thaker, Nicholas Waglechner, Irene Tang, Gerard D Wright
Reference: Chembiochem. 2014 Nov 24;15(17):2613-23. doi: 10.1002/cbic.201402179. 
PMID: 25255985 

November 24, 2014
A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria
May 13, 2014
A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria
May 13, 2014

Authors: Peter Spanogiannopoulos, Nicholas Waglechner, Kalinka Koteva, Gerard D Wright
Reference: Proc Natl Acad Sci U S A. 2014 May 13;111(19):7102-7. doi: 10.1073/pnas.1402358111
PMID: 24778229 

May 13, 2014
An unusual class of anthracyclines potentiate Gram-positive antibiotics in intrinsically resistant Gram-negative bacteria
March 13, 2014
An unusual class of anthracyclines potentiate Gram-positive antibiotics in intrinsically resistant Gram-negative bacteria
March 13, 2014

Authors: Georgina Cox, Kalinka Koteva, Gerard D Wright
Reference: J Antimicrob Chemother. 2014 Jul;69(7):1844-55. doi: 10.1093/jac/dku057.
PMID: 24627312 

March 13, 2014
February 1, 2014
Designing analogs of ticlopidine, a wall teichoic acid inhibitor, to avoid formation of its oxidative metabolites
February 1, 2014

Authors: Maya A Farha, Kalinka Koteva, Robert T Gale, Edward W Sewell, Gerard D Wright, Eric D Brown
Reference: Bioorg Med Chem Lett. 2014 Feb 1;24(3):905-10. doi: 10.1016/j.bmcl.2013.12.069.
PMID: 24393581 

February 1, 2014
January 1, 2014
Glycopeptide antibiotic biosynthesis
January 1, 2014

Authors: Grace Yim, Maulik N Thaker, Kalinka Koteva, Gerard Wright
Reference: J Antibiot (Tokyo). 2014 Jan;67(1):31-41. doi: 10.1038/ja.2013.117.
PMID: 24220108

January 1, 2014
Self resistance to the atypical cationic antimicrobial peptide edeine of Brevibacillus brevis Vm4 by the N-acetyltransferase EdeQ
August 22, 2013
Self resistance to the atypical cationic antimicrobial peptide edeine of Brevibacillus brevis Vm4 by the N-acetyltransferase EdeQ
August 22, 2013

Authors: Erin L Westman, Marie Yan, Nicholas Waglechner, Kalinka Koteva, Gerard D Wright
Reference: Chem Biol. 2013 Aug 22;20(8):983-90. doi: 10.1016/j.chembiol.2013.06.010.
PMID: 23891151 

August 22, 2013
The comprehensive antibiotic resistance database
July 1, 2013
The comprehensive antibiotic resistance database
July 1, 2013

Authors: Andrew G McArthur, Nicholas Waglechner, Fazmin Nizam, Austin Yan, Marisa A Azad, Alison J Baylay, Kirandeep Bhullar, Marc J Canova, Gianfranco De Pascale, Linda Ejim, Lindsay Kalan, Andrew M King, Kalinka Koteva, Mariya Morar, Michael R Mulvey, Jonathan S O'Brien, Andrew C Pawlowski, Laura JV Piddock, Peter Spanogiannopoulos, Arlene D Sutherland, Irene Tang, Patricia L Taylor, Maulik Thaker, Wenliang Wang, Marie Yan, Tennison Yu, Gerard D Wright
Reference: Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57. doi: 10.1128/AAC.00419-13
PMID: 23650175

July 1, 2013
January 1, 2013
Glycopeptide sulfation evades resistance
January 1, 2013

Authors: Lindsay Kalan, Julie Perry, Kalinka Koteva, Maulik Thaker, Gerard Wright
Reference: J Bacteriol. 2013 Jan;195(1):167-71. doi: 10.1128/JB.01617-12. 
PMID: 23104813

January 1, 2013
Bacterial inactivation of the anticancer drug doxorubicin
October 26, 2012
Bacterial inactivation of the anticancer drug doxorubicin
October 26, 2012

Authors: Erin L Westman, Marc J Canova, Inas J Radhi, Kalinka Koteva, Inga Kireeva, Nicholas Waglechner, Gerard D Wright
Reference: Chem Biol. 2012 Oct 26;19(10):1255-64. doi: 10.1016/j.chembiol.2012.08.011.
PMID: 23102220

October 26, 2012
Characterization of a rifampin-inactivating glycosyltransferase from a screen of environmental actinomycetes
October 1, 2012
Characterization of a rifampin-inactivating glycosyltransferase from a screen of environmental actinomycetes
October 1, 2012

Authors: Peter Spanogiannopoulos, Maulik Thaker, Kalinka Koteva, Nicholas Waglechner, Gerard D Wright
Reference: Antimicrob Agents Chemother. 2012 Oct;56(10):5061-9. doi: 10.1128/AAC.01166-12. 
PMID: 22802246 

October 1, 2012
Antibiotic resistance is prevalent in an isolated cave microbiome
April 11, 2012
Antibiotic resistance is prevalent in an isolated cave microbiome
April 11, 2012

Authors: Kirandeep Bhullar, Nicholas Waglechner, Andrew Pawlowski, Kalinka Koteva, Eric D Banks, Michael D Johnston, Hazel A Barton, Gerard D Wright
Reference: PLoS One. 2012;7(4):e34953. doi: 10.1371/journal.pone.0034953.
PMID: 22509370 

April 11, 2012
March 1, 2012
Small-molecule modulators of Listeria monocytogenes biofilm development
March 1, 2012

Authors: Uyen T Nguyen, Iwona B Wenderska, Matthew A Chong, Kalinka Koteva, Gerard D Wright, Lori L Burrows
Reference: Appl Environ Microbiol. 2012 Mar;78(5):1454-65. doi: 10.1128/AEM.07227-11. 
PMID: 22194285 

March 1, 2012
February 10, 2012
Mechanism and diversity of the erythromycin esterase family of enzymes
February 10, 2012

Authors: Mariya Morar, Kate Pengelly, Kalinka Koteva, Gerard D Wright
Reference: Biochemistry. 2012 Feb 28;51(8):1740-51. doi: 10.1021/bi201790u.
PMID: 22303981 

February 10, 2012
 
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