Haley joined the Wright lab in May 2016 to work on expanding the number of characterized resistance genes that make up the Antibiotic Resistance Platform (ARP). Since then, she has completed her fourth year undergraduate thesis in the lab which involved high-throughput screening for a natural product inhibitor of the tetracycline efflux pump, TetA. For her graduate studies, Haley is now investigating the mechanistic enzymology of β-amino acid synthesis in the peptide antibiotic edeine.
Haley's favourite things outside of the lab include coffee, Game of Thrones, and junk-food.
Haley's project involves using a combination of molecular and structural biology, biochemistry, and mechanistic enzymology to develop a better understanding of edeine biosynthesis.
Authors: Zubyk HL, Wright GD.
Reference: Antimicrob Agents Chemother.
DOI: 10.1128/AAC.00773-21.
PMID: 34001507.
Authors: Tsang KK, Maguire F, Zubyk HL, Chou S, Edalatmand A, Wright GD, Beiko RG, McArthur AG.
Reference: Microb Genom
DOI: 10.1099/mgen.0.000500
PMID: 33416461
Authors: Alcock BP, Raphenya AR, Lau TTY, Tsang KK, Bouchard M, Edalatmand A, Huynh W, Nguyen AV, Cheng AA, Liu S, Min SY, Miroshnichenko A, Tran HK, Werfalli RE, Nasir JA, Oloni M, Speicher DJ, Florescu A, Singh B, Faltyn M, Hernandez-Koutoucheva A, Sharma AN, Bordeleau E, Pawlowski AC, Zubyk HL, Dooley D, Griffiths E, Maguire F, Winsor GL, Beiko RG, Brinkman FSL, Hsiao WWL, Domselaar GV, McArthur AG.
Reference: Nucleic Acids Res.
DOI: 10.1093/nar/gkz935
PMID: 31665441
Authors: Zubyk HL, Cox G and Wright GD
Reference: J Vis Exp.
DOI: 10.3791/60536
PMID: 31680676
Authors: Stogios PJ, Cox G, Zubyk HL, Evdokimova E, Wawrzak Z, Wright GD, Savchenko A
Reference: ACS Chemical Biology 2018 13 (5), 1322-1332
DOI: 10.1021/acschembio.8b00116
PMID: 29631403
Authors: Koteva K, Cox G, Kelso JK, Surette MD, Zubyk HL, Ejim L, Stogios P, Savchenko A, Sørensen, Wright GD
Reference: Cell Chemical Biology 2018 Jan 26. pii: S2451-9456(18)30031-X
DOI: 10.1016/j.chembiol.2018.01.009.
PMID: 29398560