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The Wright Lab

  • Welcome
  • Lab News
  • Team
    • Gerry Wright
    • The Lab
  • Research
    • An Overview
    • Antimicrobial Discovery
    • Antibiotic Resistance
  • Publications
  • Platforms
    • Wright Actinomycete Collection
    • Wright Clinical Collection
    • Antibiotic Resistance Platform
    • The Comprehensive Antibiotic Resistance Database
  • Articles
  • Contact
 

zubykhl@mcmaster.ca

Haley Zubyk

Position: Ph.D. Candidate

About:

Haley joined the Wright lab in May 2016 to work on expanding the number of characterized resistance genes that make up the Antibiotic Resistance Platform (ARP). Since then, she has completed her fourth year undergraduate thesis in the lab which involved high-throughput screening for a natural product inhibitor of the tetracycline efflux pump, TetA. For her graduate studies, Haley is now investigating the mechanistic enzymology of β-amino acid synthesis in the peptide antibiotic edeine. 

Haley's favourite things outside of the lab include coffee, Game of Thrones, and junk-food.

 
Email
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Research Interests:

Haley's project involves using a combination of molecular and structural biology, biochemistry, and mechanistic enzymology to develop a better understanding of edeine biosynthesis. 

 

Publications:

 
Featured
CrpP Is Not a Fluoroquinolone-Inactivating Enzyme
Jul 16, 2021
CrpP Is Not a Fluoroquinolone-Inactivating Enzyme
Jul 16, 2021

Authors: Zubyk HL, Wright GD.
Reference: Antimicrob Agents Chemother.
DOI: 10.1128/AAC.00773-21.
PMID: 34001507.

Jul 16, 2021
Identifying novel β-lactamase substrate activity through in silico prediction of antimicrobial resistance
Jan 7, 2021
Identifying novel β-lactamase substrate activity through in silico prediction of antimicrobial resistance
Jan 7, 2021

Authors: Tsang KK, Maguire F, Zubyk HL, Chou S, Edalatmand A, Wright GD, Beiko RG, McArthur AG.
Reference: Microb Genom
DOI: 10.1099/mgen.0.000500
PMID: 33416461

Jan 7, 2021
CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database
Jan 8, 2020
CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database
Jan 8, 2020

Authors: Alcock BP, Raphenya AR, Lau TTY, Tsang KK, Bouchard M, Edalatmand A, Huynh W, Nguyen AV, Cheng AA, Liu S, Min SY, Miroshnichenko A, Tran HK, Werfalli RE, Nasir JA, Oloni M, Speicher DJ, Florescu A, Singh B, Faltyn M, Hernandez-Koutoucheva A, Sharma AN, Bordeleau E, Pawlowski AC, Zubyk HL, Dooley D, Griffiths E, Maguire F, Winsor GL, Beiko RG, Brinkman FSL, Hsiao WWL, Domselaar GV, McArthur AG.
Reference: Nucleic Acids Res.
DOI: 10.1093/nar/gkz935
PMID: 31665441

Jan 8, 2020
Oct 17, 2019
Antibiotic Dereplication Using the Antibiotic Resistance Platform
Oct 17, 2019

Authors: Zubyk HL, Cox G and Wright GD
Reference: J Vis Exp.
DOI: 10.3791/60536
PMID: 31680676

Oct 17, 2019
Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis
Jun 4, 2018
Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis
Jun 4, 2018

Authors: Stogios PJ, Cox G, Zubyk HL, Evdokimova E, Wawrzak Z, Wright GD, Savchenko A
Reference: 
ACS Chemical Biology 2018 13 (5), 1322-1332
DOI: 
10.1021/acschembio.8b00116
PMID: 
29631403

Jun 4, 2018
Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action.
Feb 1, 2018
Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action.
Feb 1, 2018

Authors: Koteva K, Cox G, Kelso JK, Surette MD, Zubyk HL, Ejim L, Stogios P, Savchenko A, Sørensen, Wright GD
Reference: Cell Chemical Biology 2018 Jan 26. pii: S2451-9456(18)30031-X
DOI: 10.1016/j.chembiol.2018.01.009.
PMID: 29398560

Feb 1, 2018
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