Dave obtained his BSc in Microbiology at the University of Guelph and followed this with graduate studies (MSc and PhD) with Anthony Clarke (Molecular and Cellular Biology), where he worked on the structure/function relationships of polysaccharide O-acetyltransferases. He completed his graduate work in early 2018 and joined the Wright lab as a postdoc later that spring.
Some of Dave's research interests include the structure, mechanism, and inhibition of enzymes from bacteria. Currently, he is working on the discovery and characterization of inhibitors of metallo-β-lactamases and bacterial cell wall biosynthesis.
Authors: Culp EJ, Sychantha D, Hobson C, Pawlowski AC, Prehna G, Wright GD.
Reference: Nat Microbiol.
DOI: 10.1038/s41564-022-01073-4.
PMID: 35246663.
Authors: Koteva K, Sychantha D, Rotondo CM, Hobson C, Britten JF, Wright GD.
Reference: ACS Omega.
DOI: 10.1021/acsomega.1c05757.
PMID: 35155911.
Authors: Sychantha D, Rotondo CM, Tehrani KHME, Martin NI, Wright GD.
Reference: J Biol Chem.
DOI: 10.1016/j.jbc.2021.100918.
PMID: PMC8319579.
Authors: Culp EJ, Waglecher N, Wang W, Fiebig-Comyn AA, Hsu Y, Koteva K, Sychantha D, Coombes BK, Van Nieuwenhze MS, Brun YV and Wright GD
Reference: Nature
DOI: 10.1038/s41586-020-1990-9
PMID: 32051588
Authors: Rotondo CM, Sychantha D, Koteva K and Wright GD
Reference: Antimicrob Agents Chemother.
DOI: 10.1128/AAC.01386-19
PMID: 31932375
Congratulations to three trainees from the Michael G. DeGroote Institute for Infectious Disease Research and David Braley Centre for Antibiotic Discovery on receiving prestigious Research Awards from the Canadian Institutes of Health Research (CIHR).