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The Wright Lab

  • Welcome
  • Lab News
  • Team
    • Gerry Wright
    • The Lab
  • Research
    • An Overview
    • Antimicrobial Discovery
    • Antibiotic Resistance
  • Publications
  • Platforms
    • Wright Actinomycete Collection
    • Wright Clinical Collection
    • Antibiotic Resistance Platform
    • The Comprehensive Antibiotic Resistance Database
  • Articles
  • Contact
 
dave.png

David Sychantha, Ph.D

Position: Postdoctoral Fellow

About:

Dave obtained his BSc in Microbiology at the University of Guelph and followed this with graduate studies (MSc and PhD) with Anthony Clarke (Molecular and Cellular Biology), where he worked on the structure/function relationships of polysaccharide O-acetyltransferases. He completed his graduate work in early 2018 and joined the Wright lab as a postdoc later that spring.

 
Email
 

Research Interests:

Some of Dave's research interests include the structure, mechanism, and inhibition of enzymes from bacteria. Currently, he is working on the discovery and characterization of inhibitors of metallo-β-lactamases and bacterial cell wall biosynthesis.

Publications:

Featured
Targeting bacterial nickel transport with aspergillomarasmine A suppresses virulence-associated Ni-dependent enzymes
Jun 10, 2024
Targeting bacterial nickel transport with aspergillomarasmine A suppresses virulence-associated Ni-dependent enzymes
Jun 10, 2024

Authors: Sychantha D, Chen X, Koteva K, Prehna G, Wright G.D.
Reference: Nature Communications 
DOI:  10.1038/s41467-024-48232-1
PMID: 38740750

Jun 10, 2024
ClpP inhibitors are produced by a widespread family of bacterial gene clusters
Mar 4, 2022
ClpP inhibitors are produced by a widespread family of bacterial gene clusters
Mar 4, 2022

Authors: Culp EJ, Sychantha D, Hobson C, Pawlowski AC, Prehna G, Wright GD.
Reference: Nat Microbiol.
DOI: 10.1038/s41564-022-01073-4.
PMID: 35246663.

Mar 4, 2022
Three-Dimensional Structure and Optimization of the Metallo-β-Lactamase Inhibitor Aspergillomarasmine A
Jan 26, 2022
Three-Dimensional Structure and Optimization of the Metallo-β-Lactamase Inhibitor Aspergillomarasmine A
Jan 26, 2022

Authors: Koteva K, Sychantha D, Rotondo CM, Hobson C, Britten JF, Wright GD.
Reference: ACS Omega.
DOI: 10.1021/acsomega.1c05757.
PMID: 35155911.

Jan 26, 2022
Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2
Jun 25, 2021
Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2
Jun 25, 2021

Authors: Sychantha D, Rotondo CM, Tehrani KHME, Martin NI, Wright GD.
Reference: J Biol Chem.
DOI: 10.1016/j.jbc.2021.100918.
PMID: PMC8319579.

Jun 25, 2021
Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling
Feb 12, 2020
Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling
Feb 12, 2020

Authors: Culp EJ, Waglecher N, Wang W, Fiebig-Comyn AA, Hsu Y, Koteva K, Sychantha D, Coombes BK, Van Nieuwenhze MS, Brun YV and Wright GD
Reference: Nature
DOI: 10.1038/s41586-020-1990-9
PMID: 32051588

Feb 12, 2020
Suppression of β-Lactam Resistance by Aspergillomarasmine A Is Influenced by both the Metallo-β-Lactamase Target and the Antibiotic Partner
Jan 14, 2020
Suppression of β-Lactam Resistance by Aspergillomarasmine A Is Influenced by both the Metallo-β-Lactamase Target and the Antibiotic Partner
Jan 14, 2020

Authors: Rotondo CM, Sychantha D, Koteva K and Wright GD
Reference: Antimicrob Agents Chemother.
DOI: 10.1128/AAC.01386-19
PMID: 31932375

Jan 14, 2020

In the News:

Featured
Wright Lab “AMR Resistance Fighters” Receive CIHR Research Awards
Apr 24, 2019
Wright Lab “AMR Resistance Fighters” Receive CIHR Research Awards
Apr 24, 2019

Congratulations to three trainees from the Michael G. DeGroote Institute for Infectious Disease Research and David Braley Centre for Antibiotic Discovery on receiving prestigious Research Awards from the Canadian Institutes of Health Research (CIHR).

Apr 24, 2019
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