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The Wright Lab

  • Welcome
  • Lab News
  • Team
    • Gerry Wright
    • The Lab
  • Research
    • An Overview
    • Antimicrobial Discovery
    • Antibiotic Resistance
  • Publications
  • Platforms
    • Wright Actinomycete Collection
    • Wright Clinical Collection
    • Antibiotic Resistance Platform
    • The Comprehensive Antibiotic Resistance Database
  • Articles
  • Contact
 

rotondoc@mcmaster.ca

Caitlyn Rotondo, M.Sc.

Position: Ph.D. Candidate

About:

Caitlyn joined the Wright Lab in 2016 as a Ph.D. student after completing both a Bachelor of Science in Biochemistry and a Master of Science in Chemical Sciences at Laurentian University in Sudbury, Ontario.  

Apart from Caitlyn’s love of science, she enjoys reading and spending time with family and friends. In addition, Caitlyn likes to roller blade, swim and play tennis.

Email

Research Interests:

Metallo-β-lactamases (MBLs) contribute largely to the problem of bacterial resistance to antibiotics as they have the capability of inactivating most β-lactam antibiotics. At the present time, there are no clinically approved inhibitors of MBLs. However, previous studies conducted in the Wright Lab have uncovered an effective inhibitor of two clinically relevant MBLs: NDM-1 and VIM-2. This inhibitor is known as aspergillomarasmine A (AMA), a natural product synthesized by the fungus Aspergillus versicolor. Caitlyn's research is focused on investigating unknown questions still surrounding AMA such as its biosynthesis in A. versicolor.

Publications:

Featured
Three-Dimensional Structure and Optimization of the Metallo-β-Lactamase Inhibitor Aspergillomarasmine A
Jan 26, 2022
Three-Dimensional Structure and Optimization of the Metallo-β-Lactamase Inhibitor Aspergillomarasmine A
Jan 26, 2022

Authors: Koteva K, Sychantha D, Rotondo CM, Hobson C, Britten JF, Wright GD.
Reference: ACS Omega.
DOI: 10.1021/acsomega.1c05757.
PMID: 35155911.

Jan 26, 2022
Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2
Jun 25, 2021
Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2
Jun 25, 2021

Authors: Sychantha D, Rotondo CM, Tehrani KHME, Martin NI, Wright GD.
Reference: J Biol Chem.
DOI: 10.1016/j.jbc.2021.100918.
PMID: PMC8319579.

Jun 25, 2021
Suppression of β-Lactam Resistance by Aspergillomarasmine A Is Influenced by both the Metallo-β-Lactamase Target and the Antibiotic Partner
Jan 14, 2020
Suppression of β-Lactam Resistance by Aspergillomarasmine A Is Influenced by both the Metallo-β-Lactamase Target and the Antibiotic Partner
Jan 14, 2020

Authors: Rotondo CM, Sychantha D, Koteva K and Wright GD
Reference: Antimicrob Agents Chemother.
DOI: 10.1128/AAC.01386-19
PMID: 31932375

Jan 14, 2020
Inhibitors of metallo-β-lactamases.
Nov 16, 2017
Inhibitors of metallo-β-lactamases.
Nov 16, 2017

Authors: CM Rotondo and GD Wright
Reference: Current Opinion in Microbiology 2017 39: 96-105
PMID: 29154026

Nov 16, 2017
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