In this video, Arthur Sieron, Georgina Cox, and Gerry Wright discuss antibiotic adjuvants as an orthogonal way to extend the effectiveness of antibiotics given increasing amounts of antibiotic resistance found in bacteria.
Rooted in the mechanism of action of antibiotics and subject to bacterial evolution, antibiotic resistance is difficult and perhaps impossible to overcome. Nevertheless, strategies can be used to minimize the emergence and impact of resistance. Antibiotic adjuvants offer one such approach. These are compounds that have little or no antibiotic activity themselves but act to block resistance or otherwise enhance antibiotic action.