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PMID: 26284661
Structural and functional plasticity of antibiotic resistance nucleotidylyltransferases revealed by molecular characterization of lincosamide nucleotidylyltransferases lnu (A) and lnu (D) →
Authors: Peter J Stogios, Elena Evdokimova, Mariya Morar, Kalinka Koteva, Gerard D Wright, Patrice Courvalin, Alexei Savchenko
Reference: J Mol Biol. 2015 Jun 19;427(12):2229-43. doi: 10.1016/j.jmb.2015.04.008
PMID: 25900373
Zinc Chelation by a Small-Molecule Adjuvant Potentiates Meropenem Activity in Vivo against NDM-1-Producing Klebsiella pneumoniae →
Authors: Shannon B Falconer, Sarah A Reid-Yu, Andrew M King, Sebastian S Gehrke, Wenliang Wang, James F Britten, Brian K Coombes, Gerard D Wright, Eric D Brown
Reference: ACS Infect Dis. 2015 Nov 13;1(11):533-43. doi: 10.1021/acsinfecdis.5b00033
PMID: 27623408
Alternative pathway to a glycopeptide-resistant cell wall in the balhimycin producer Amycolatopsis balhimycina →
Authors: Hans-Joerg Frasch, Lindsay Kalan, Regina Kilian, Tobias Martin, Gerard D Wright, Evi Stegmann
Reference: ACS Infect Dis. 2015 Jun 12;1(6):243-52. doi: 10.1021/acsinfecdis.5b00011.
PMID: 27622740
Vancomycin-variable enterococci can give rise to constitutive resistance during antibiotic therapy →
Authors: Maulik N Thaker, Lindsay Kalan, Nicholas Waglechner, Alireza Eshaghi, Samir N Patel, Susan Poutanen, Barbara Willey, Bryan Coburn, Allison McGeer, Donald E Low, Gerard D Wright
Reference: Antimicrob Agents Chemother. 2015 Mar;59(3):1405-10. doi: 10.1128/AAC.04490-14.
PMID: 25512425
Structural and molecular basis for resistance to aminoglycoside antibiotics by the adenylyltransferase ANT (2 ″)-Ia →
Authors: Georgina Cox, Peter J Stogios, Alexei Savchenko, Gerard D Wright
Reference: MBio. 2015 Jan 6;6(1). pii: e02180-14. doi: 10.1128/mBio.02180-14.
PMID: 25564464
Molecular mechanism of avibactam-mediated β-lactamase inhibition →
Authors: Dustin T King, Andrew M King, Sarah M Lal, Gerard D Wright, Natalie CJ Strynadka
Reference: ACS Infect Dis. 2015 Apr 10;1(4):175-84. doi: 10.1021/acsinfecdis.5b00007. Epub 2015 Feb 11.
PMID: 27622530
Antibiotics: An irresistible newcomer →
Authors: Gerard Wright
Reference: Nature. 2015 Jan 22;517(7535):442-4. doi: 10.1038/nature14193.
PMID: 25561172
Solving the antibiotic crisis →
Authors: Gerard D Wright
Reference: ACS Infect Dis. 2015 Feb 13;1(2):80-4. doi: 10.1021/id500052s.
PMID: 27622298
Winners of the 2014 JA Medals for excellence →
Authors: Gerard D Wright, Minoru Yoshida
Reference: J Antibiot (Tokyo). 2015 Jan;68(1):1-2. doi: 10.1038/ja.2014.156.
PMID: 25623837
Forces shaping the antibiotic resistome →
Authors: Julie A Perry, Gerard D Wright
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PMID: 25213620
Harnessing the Synthetic Capabilities of Glycopeptide Antibiotic Tailoring Enzymes: Characterization of the UK‐68,597 Biosynthetic Cluster →
Authors: Grace Yim, Lindsay Kalan, Kalinka Koteva, Maulik N Thaker, Nicholas Waglechner, Irene Tang, Gerard D Wright
Reference: Chembiochem. 2014 Nov 24;15(17):2613-23. doi: 10.1002/cbic.201402179.
PMID: 25255985
Role of PBPD1 in Stimulation of Listeria monocytogenes Biofilm Formation by Subminimal Inhibitory β-Lactam Concentrations →
Authors: Uyen T Nguyen, Hanjeong Harvey, Andrew J Hogan, Alexandria CF Afonso, Gerard D Wright, Lori L Burrows
Reference: Antimicrob Agents Chemother. 2014 Nov;58(11):6508-17. doi: 10.1128/AAC.03671-14.
PMID: 25136010
Inhibition of the ANT (2 ″)-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones →
Authors: Danielle R Hirsch, Georgina Cox, Michael P D’Erasmo, Tushar Shakya, Christine Meck, Noushad Mohd, Gerard D Wright, Ryan P Murelli
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PMID: 25283553
The antibiotic resistome: what's new? →
Authors: Julie Ann Perry, Erin Louise Westman, Gerard D Wright
Reference: Curr Opin Microbiol. 2014 Oct;21:45-50. doi: 10.1016/j.mib.2014.09.002.
PMID: 25280222
A macrophage-stimulating compound from a screen of microbial natural products →
Authors: Perry JA, Koteva K, Verschoor CP, Wang W, Bowdish DM, Wright GD.
Reference: J Antibiot (Tokyo). 2015 Jan;68(1):40-6. doi: 10.1038/ja.2014.83.
PMID: 24984798
Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance. →
Authors: Andrew M King, Sarah A Reid-Yu, Wenliang Wang, Dustin T King, Gianfranco De Pascale, Natalie C Strynadka, Timothy R Walsh, Brian K Coombes, Gerard D Wright
Reference: Nature. 2014 Jun 26;510(7506):503-6. doi: 10.1038/nature13445.
PMID: 24965651
Antibiotic resistance–mediated isolation of scaffold-specific natural product producers →
Authors: Maulik N Thaker, Nicholas Waglechner and Gerry D Wright
Reference: Nature Protocols 9, 1469–1479 (2014) doi:10.1038/nprot.2014.093
PMID: 24874813
A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria →
Authors: Peter Spanogiannopoulos, Nicholas Waglechner, Kalinka Koteva, Gerard D Wright
Reference: Proc Natl Acad Sci U S A. 2014 May 13;111(19):7102-7. doi: 10.1073/pnas.1402358111
PMID: 24778229
Perspective: synthetic biology revives antibiotics →
Authors: Gerard Wright
Reference: Nature. 2014 May 1;509(7498):S13. doi: 10.1038/509S13a.
PMID: 24784423