The Antibiotic Resistance Platform (ARP) is a cell-based array of mechanistically distinct individual resistance elements in an identical genetic background. The ARP consists of resistance elements to 15 classes of antibiotic, represented by the inner wheel. Each class is represented by a unique colour (see key). The middle wheel divides the 15 classes into individual antibiotics found within each class. The outer wheel depicts the array of resistance genes within the ARP, grouped based on antibiotic substrate specificity.
Authors: Cox G, Sieron A, King AM, De Pascale G, Pawlowski AC, Koteva K, Wright GD.
Reference: Cell Chem Biol. 2016 Nov 29. pii: S2451-9456(16)30434-2. doi: 10.1016/j.chembiol.2016.11.011.
Authors: Andrew M King, Sarah A Reid-Yu, Wenliang Wang, Dustin T King, Gianfranco De Pascale, Natalie C Strynadka, Timothy R Walsh, Brian K Coombes, Gerard D Wright
Reference: Nature. 2014 Jun 26;510(7506):503-6. doi: 10.1038/nature13445.