Antibiotics are vital components of modern medicine. However, their use is jeopardized by the spread of bacteria that have acquired resistance to their activity. This resistance can take many forms including enzymatic destruction of drugs, efflux, and target modification. To address the problem of antibiotic resistance, the Wright lab is using complementary research strategies. The first is the direct study of the molecular mechanisms of bacterial antibiotic resistance using chemical biology and chemical genetics. The second is the identification of new antibiotics and new antimicrobial strategies. These complementary approaches of fundamental and applied research are being pursued using a multidisciplinary approach supported by state of the art infrastructure in the Centre for Microbial Chemical Biology. Click the following link http://www.cmcbmcmaster.ca/ to visit the CMCB.