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The Wright Lab

  • Welcome
  • Home
  • About
    • Gerry Wright
    • The Lab
  • Research
    • An Overview
    • Antibiotic Resistance
    • Antimicrobial Discovery
  • Publications
  • Platforms
    • Wright Actinomycete Collection
    • Comprehensive Antibiotic Database
    • Antibiotic Resistance Platform
  • Updates
  • Contact

Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function

 
Chemical Structure of Ibomycin

Chemical Structure of Ibomycin

 
 
 

Natural products are invaluable historic sources of drugs for infectious diseases; however, the discovery of novel antimicrobial chemical scaffolds has waned in recent years. Concurrently, there is a pressing need for improved therapeutics to treat fungal infections. We employed a co-culture screen to identify ibomycin, a large polyketide macrolactone that has preferential killing activity against Cryptococcus neoformans. 

 
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