Authors: Cox G, Sieron A, King AM, De Pascale G, Pawlowski AC, Koteva K, Wright GD.
Reference: Cell Chem Biol. 2016 Nov 29. pii: S2451-9456(16)30434-2. doi: 10.1016/j.chembiol.2016.11.011.
PMID: 28017602
Systematic chemical-genetic and chemical-chemical interaction datasets for prediction of compound synergism
Authors: Wildenhain J, Spitzer M, Dolma S, Jarvik N, White R, Roy M, Griffiths E, Bellows DS, Wright GD, Tyers M.
Reference: Scientific Data 3, Article number: 160095 (2016). doi:10.1038/sdata.2016.95
PMID: 2787484
Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function →
Authors: Robbins N, Spitzer M, Wang W, Waglechner N, Patel DJ, O'Brien JS, Ejim L, Ejim O, Tyers M, Wright GD.
Reference: Cell Chem Biol. 2016 Nov 17;23(11):1383-1394. doi: 10.1016/j.chembiol.2016.08.015.
PMID: 27746129
Catalytic promiscuity of glycopeptide N-methyltransferases enables bio-orthogonal labelling of biosynthetic intermediates →
Authors: Brieke C, Yim G, Peschke M, Wright GD, Cryle MJ.
Reference: Chem Commun (Camb). 2016 Nov 17;52(94):13679-13682.
PMID: 27812569
Total Synthesis of Aspergillomarasmine A and Related Compounds: A Sulfamidate Approach Enables Exploration of Structure–Activity Relationships →
Authors: SA Albu, K Koteva, AM King, S Al‐Karmi, GD Wright, A Capretta
Reference: Angew Chem Int Ed Engl. 2016 Oct 10;55(42):13259-13262. doi: 10.1002/anie.201606657.
PMID: 27633338
How To Make a Glycopeptide: A Synthetic Biology Approach To Expand Antibiotic Chemical Diversity →
Authors: G Yim, W Wang, MN Thaker, S Tan, GD Wright
Reference: ACS Infect. Dis., 2016, 2 (9), pp 642–650 DOI: 10.1021/acsinfecdis.6b00105
Antibiotic Adjuvants: Rescuing Antibiotics from Resistance →
Authors: GD Wright
Reference: Trends Microbiol. 2016 Jul 15. pii: S0966-842X(16)30072-5. doi: 10.1016/j.tim.2016.06.009.
PMID: 27430191
Combinatorial Strategies For Combating Invasive Fungal Infections →
Authors: M Spitzer, N Robbins, GD Wright
Reference: Virulence. 2016 Jun 7:1-17.
PMID: 27268286
The Prehistory of Antibiotic Resistance →
Authors: J Perry, N Waglechner, G Wright
Reference: Cold Spring Harbor perspectives in medicine 6 (6), a025197
PMID: 27252395
Rifampin phosphotransferase is an unusual antibiotic resistance kinase →
Authors: Peter J Stogios, Georgina Cox, Peter Spanogiannopoulos, Monica C Pillon, Nicholas Waglechner, Tatiana Skarina, Kalinka Koteva, Alba Guarné, Alexei Savchenko, Gerard D Wright
Reference: Nat Commun. 2016 Apr 22;7:11343. doi: 10.1038/ncomms11343.
PMID: 27103605
Beating Superbugs: Innovative Genomics and Policies to Tackle AMR →
Authors: Rainer Engelhardt, Gerard Wright
Reference: Genome Canada Policy Brief No. 11
Total Synthesis and Activity of the Metallo‐β‐lactamase Inhibitor Aspergillomarasmine A →
Authors: K Koteva, AM King, A Capretta, GD Wright
Reference: Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2210-2. doi: 10.1002/anie.201510057.
PMID: 26709849
Antibacterial drug discovery in the resistance era →
Authors: ED Brown, GD Wright
Reference: Nature. 2016 Jan 21;529(7586):336-43. doi: 10.1038/nature17042.
PMID: 26791724
Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins →
Authors: Andrew M King, Dustin T King, Shawn French, Eric Brouillette, Abdelhamid Asli, J Andrew N Alexander, Marija Vuckovic, Samarendra N Maiti, Thomas R Parr Jr, Eric D Brown, François Malouin, Natalie CJ Strynadka, Gerard D Wright
Reference: ACS Chem Biol. 2016 Apr 15;11(4):864-8. doi: 10.1021/acschembio.5b00944.
PMID: 26731698
Antibiotic Resistance themed issue →
Authors: S Garneau-Tsodikova, GD Wright
Reference: MedChemComm 7 (1), 10-10
Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning. →
Authors: Jan Wildenhain, Michaela Spitzer, Sonam Dolma, Nick Jarvik, Rachel White, Marcia Roy, Emma Griffiths, David S Bellows, Gerard D Wright, Mike Tyers
Reference: Cell Syst. 2015 Dec 23;1(6):383-95. doi: 10.1016/j.cels.2015.12.003.
PMID: 27136353
An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens →
Authors: Nicole Robbins, Michaela Spitzer, Tennison Yu, Robert P Cerone, Anna K Averette, Yong-Sun Bahn, Joseph Heitman, Donald C Sheppard, Mike Tyers, Gerard D Wright
Reference: Cell Rep. 2015 Nov 17;13(7):1481-92. doi: 10.1016/j.celrep.2015.10.018.
PMID: 26549450
Biosynthesis of the Fluorinated Natural Product Nucleocidin in Streptomyces calvus Is Dependent on the bldA‐Specified Leu‐tRNAUUA Molecule →
Authors: Xi Ming Zhu, Stefanie Hackl, Maulik N Thaker, Lindsay Kalan, Claudia Weber, Dagmar S Urgast, Eva M Krupp, Alyssa Brewer, Stephanie Vanner, Anjuli Szawiola, Grace Yim, Jörg Feldmann, Andreas Bechthold, Gerard D Wright, David L Zechel
Reference: Chembiochem. 2015 Nov;16(17):2498-506. doi: 10.1002/cbic.201500402
PMID: 26374477
Bioinformatics of antimicrobial resistance in the age of molecular epidemiology →
Authors: Andrew G McArthur, Gerard D Wright
Reference: Curr Opin Microbiol. 2015 Oct;27:45-50. doi: 10.1016/j.mib.2015.07.004
PMID: 26241506
Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium →
Authors: Luca Freschi, Julie Jeukens, Irena Kukavica-Ibrulj, Brian Boyle, Marie-Josée Dupont, Jérôme Laroche, Stéphane Larose, Halim Maaroufi, Joanne L Fothergill, Matthew Moore, Geoffrey L Winsor, Shawn D Aaron, Jean Barbeau, Scott C Bell, Jane L Burns, Miguel Camara, André Cantin, Steve J Charette, Ken Dewar, Éric Déziel, Keith Grimwood, Robert EW Hancock, Joe J Harrison, Stephan Heeb, Lars Jelsbak, Baofeng Jia, Dervla T Kenna, Timothy J Kidd, Jens Klockgether, Joseph S Lam, Iain L Lamont, Shawn Lewenza, Nick Loman, François Malouin, Jim Manos, Andrew G McArthur, Josie McKeown, Julie Milot, Hardeep Naghra, Dao Nguyen, Sheldon K Pereira, Gabriel G Perron, Jean-Paul Pirnay, Paul B Rainey, Simon Rousseau, Pedro M Santos, Anne Stephenson, Véronique Taylor, Jane F Turton, Nicholas Waglechner, Paul Williams, Sandra W Thrane, Gerard D Wright, Fiona SL Brinkman, Nicholas P Tucker, Burkhard Tümmler, Craig Winstanley, Roger C Levesque
Reference: Front Microbiol. 2015 Sep 29;6:1036. doi: 10.3389/fmicb.2015.01036
PMID: 26483767