Beth joined the lab in 2015 after completing her undergraduate degree at McMaster. If she's not in the lab, you'll probably find her running, playing trumpet, or eating chocolate.
Genome sequencing has revealed that bacteria possess the genetic capability to produce a much wider range of specialized metabolites than that observed under standard laboratory culturing. Beth's project is aimed at identifying the product of these so called 'cryptic' gene clusters by manipulating them in heterologous hosts. In doing so, previously inaccessible specialized metabolites with potential antibacterial activity can be characterized.
Beth's second project is focused on identifying novel antibiotics targeting bacterial proteases. With no clinically approved antibiotics targeting this family of enzymes, proteases offer an untapped target for antibiotic discovery.
Authors: A Yan, E Culp, J Perry, J Lau, L MacNeil, MG Surette, GD Wright
Reference: ACS Infectious Disease (Available online November 21 2017)
Authors: E Culp, GD Wright
Reference: Journal of Antibiotics (Tokyo) April; 70(4) 366-377