Arthur has recently completed an undergraduate Honours Bachelor of Science degree in Biochemistry at McMaster University. He is currently pursuing a Master of Science in Biochemistry, where he has spent time compiling a cell-based research platform that can be used to de-replicate known antibiotic classes from bioactive extracts and screen for antibiotic adjuvants. He is interested in searching for antibiotic adjuvants for clinically urgent antibiotic resistance mechanisms in an attempt to rescue existing drugs. Outside of the lab, Arthur enjoys spending time with friends, reading, and trying new cuisines.
Arthur's current project involves searching for novel inhibitors of antibiotic resistance mechanisms. Through screening an in-house natural product library consisting of crude cell extracts from over 10 000 Actinomycetes, Arthur hopes to identify a compound that has the potential to overcome antibiotic resistance elements present in the clinic.
Authors: Smith NM, Bulman ZP, Sieron AO, Bulitta JB, Holden PN, Nation RL, Li J, Wright GD, Tsuji BT.
Reference: Journal of Antimicrobial Chemotherapy 2017 Aug 1;72(8):2297-2303
Authors: Cox G, Sieron A, King AM, De Pascale G, Pawlowski AC, Koteva K, Wright GD.
Reference: Cell Chem Biol. 2016 Nov 29. pii: S2451-9456(16)30434-2. doi: 10.1016/j.chembiol.2016.11.011.